(26 nodes) Activation of Matrix Metalloproteinases network (Canis lupus familiaris)

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Your Input:
	LOC102156614	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (333 aa)
	MMP17	Matrix metallopeptidase 17. (516 aa)
	MMP24	Matrix metallopeptidase 24. (616 aa)
	MMP15	Matrix metallopeptidase 15. (618 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	MMP2	Matrix metallopeptidase 2. (610 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	CTSK	Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (446 aa)
	CMA1	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (249 aa)
	MMP13	Matrix metallopeptidase 13. (496 aa)
	MMP8	Matrix metallopeptidase 8. (476 aa)
	MMP3	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (478 aa)
	MMP25	Matrix metallopeptidase 25. (560 aa)
	CTRB2	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. (264 aa)
	MMP7	Matrix metallopeptidase 7. (263 aa)
	FRZB	Frizzled related protein. (168 aa)
	TIMP2	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (177 aa)
	SPOCK3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (370 aa)
	LOC102154527	NTR domain-containing protein. (221 aa)
	MMP1	Matrix metallopeptidase 1. (465 aa)
	CTSG	Granzyme B; Belongs to the peptidase S1 family. (351 aa)
	LOC100049001	Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. (494 aa)
	ELANE	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (313 aa)
	MMP11	Matrix metallopeptidase 11. (489 aa)
	TIMP1	Metalloproteinase inhibitor 1. (359 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (827 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMA1	CTSG	ENSCAFP00000018316	ENSCAFP00000043060	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	Granzyme B; Belongs to the peptidase S1 family.	0.597
CMA1	ELANE	ENSCAFP00000018316	ENSCAFP00000049996	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.591
CMA1	LOC100049001	ENSCAFP00000018316	ENSCAFP00000046459	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily.	0.685
CMA1	MMP1	ENSCAFP00000018316	ENSCAFP00000038708	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	Matrix metallopeptidase 1.	0.532
CTRB2	CTSG	ENSCAFP00000029763	ENSCAFP00000043060	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.	Granzyme B; Belongs to the peptidase S1 family.	0.888
CTRB2	ELANE	ENSCAFP00000029763	ENSCAFP00000049996	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.430
CTRB2	MMP3	ENSCAFP00000029763	ENSCAFP00000022195	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.761
CTSG	CMA1	ENSCAFP00000043060	ENSCAFP00000018316	Granzyme B; Belongs to the peptidase S1 family.	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	0.597
CTSG	CTRB2	ENSCAFP00000043060	ENSCAFP00000029763	Granzyme B; Belongs to the peptidase S1 family.	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.	0.888
CTSG	ELANE	ENSCAFP00000043060	ENSCAFP00000049996	Granzyme B; Belongs to the peptidase S1 family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.930
CTSG	LOC100049001	ENSCAFP00000043060	ENSCAFP00000046459	Granzyme B; Belongs to the peptidase S1 family.	Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily.	0.534
CTSG	MMP1	ENSCAFP00000043060	ENSCAFP00000038708	Granzyme B; Belongs to the peptidase S1 family.	Matrix metallopeptidase 1.	0.438
CTSK	LOC102156614	ENSCAFP00000017808	ENSCAFP00000001630	Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.564
CTSK	MMP13	ENSCAFP00000017808	ENSCAFP00000022174	Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.	Matrix metallopeptidase 13.	0.713
CTSK	MMP3	ENSCAFP00000017808	ENSCAFP00000022195	Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.630
CTSK	MMP7	ENSCAFP00000017808	ENSCAFP00000030464	Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.	Matrix metallopeptidase 7.	0.448
ELANE	CMA1	ENSCAFP00000049996	ENSCAFP00000018316	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	0.591
ELANE	CTRB2	ENSCAFP00000049996	ENSCAFP00000029763	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.	0.430
ELANE	CTSG	ENSCAFP00000049996	ENSCAFP00000043060	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Granzyme B; Belongs to the peptidase S1 family.	0.930
ELANE	LOC100049001	ENSCAFP00000049996	ENSCAFP00000046459	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily.	0.499