(24 nodes) Notch-HLH transcription pathway network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAML1	Mastermind like transcriptional coactivator 1. (1011 aa)
	HDAC10	Histone deacetylase 10. (945 aa)
	NOTCH4	Notch receptor 4. (1773 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1098 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1124 aa)
	NCOR2	Nuclear receptor corepressor 2. (2517 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1073 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	KAT2A	Lysine acetyltransferase 2A. (903 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	CREBBP	CREB binding protein. (2442 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa)
	MAMLD1	Mastermind like domain containing 1. (1036 aa)
	KAT2B	Lysine acetyltransferase 2B. (738 aa)
	SNW1	SNW domain containing 1. (536 aa)
	HDAC2	Histone deacetylase 2. (604 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1139 aa)
	TBL1X	Uncharacterized protein. (592 aa)
	HDAC6	Histone deacetylase 6. (1186 aa)
	NCOR1	Nuclear receptor corepressor 1. (2542 aa)
	HDAC11	Histone deacetylase 11. (362 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (513 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1186 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	HDAC1	ENSCAFP00000036447	ENSCAFP00000036819	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.786
CREBBP	HDAC2	ENSCAFP00000036447	ENSCAFP00000042408	CREB binding protein.	Histone deacetylase 2.	0.551
CREBBP	HDAC3	ENSCAFP00000036447	ENSCAFP00000030390	CREB binding protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.768
CREBBP	HDAC6	ENSCAFP00000036447	ENSCAFP00000049288	CREB binding protein.	Histone deacetylase 6.	0.447
CREBBP	KAT2A	ENSCAFP00000036447	ENSCAFP00000023075	CREB binding protein.	Lysine acetyltransferase 2A.	0.965
CREBBP	KAT2B	ENSCAFP00000036447	ENSCAFP00000038937	CREB binding protein.	Lysine acetyltransferase 2B.	0.865
CREBBP	MAML1	ENSCAFP00000036447	ENSCAFP00000000502	CREB binding protein.	Mastermind like transcriptional coactivator 1.	0.880
CREBBP	MAML2	ENSCAFP00000036447	ENSCAFP00000006055	CREB binding protein.	Mastermind like transcriptional coactivator 2.	0.616
CREBBP	MAML3	ENSCAFP00000036447	ENSCAFP00000005512	CREB binding protein.	Mastermind like transcriptional coactivator 3.	0.875
CREBBP	MAMLD1	ENSCAFP00000036447	ENSCAFP00000038864	CREB binding protein.	Mastermind like domain containing 1.	0.539
CREBBP	NCOR1	ENSCAFP00000036447	ENSCAFP00000053648	CREB binding protein.	Nuclear receptor corepressor 1.	0.835
CREBBP	NCOR2	ENSCAFP00000036447	ENSCAFP00000010374	CREB binding protein.	Nuclear receptor corepressor 2.	0.760
CREBBP	NOTCH4	ENSCAFP00000036447	ENSCAFP00000001124	CREB binding protein.	Notch receptor 4.	0.826
CREBBP	RBPJ	ENSCAFP00000036447	ENSCAFP00000064615	CREB binding protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.922
CREBBP	SNW1	ENSCAFP00000036447	ENSCAFP00000039963	CREB binding protein.	SNW domain containing 1.	0.827
CREBBP	TBL1X	ENSCAFP00000036447	ENSCAFP00000047420	CREB binding protein.	Uncharacterized protein.	0.591
CREBBP	TBL1XR1	ENSCAFP00000036447	ENSCAFP00000022867	CREB binding protein.	Transducin beta like 1 X-linked receptor 1.	0.556
HDAC1	CREBBP	ENSCAFP00000036819	ENSCAFP00000036447	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	CREB binding protein.	0.786
HDAC1	HDAC10	ENSCAFP00000036819	ENSCAFP00000000979	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 10.	0.584
HDAC1	HDAC11	ENSCAFP00000036819	ENSCAFP00000056345	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 11.	0.770