STRINGSTRING
UFL1 UFL1 TBK1 TBK1 NPRL3 NPRL3 SNX18 SNX18 DEPDC5 DEPDC5 ROCK1 ROCK1 PRKN PRKN ENSCAFP00000050634 ENSCAFP00000050634 PRKAA1 PRKAA1 ATG16L1 ATG16L1 TRIM6 TRIM6 SESN1 SESN1 ENSCAFP00000053367 ENSCAFP00000053367 LRSAM1 LRSAM1 TRIM13 TRIM13 PINK1 PINK1 ATF6 ATF6 SVIP SVIP MID2 MID2 ALKAL1 ALKAL1 RAB3GAP1 RAB3GAP1 PRKD1 PRKD1 TRIM68 TRIM68 SH3GLB1 SH3GLB1 SESN3 SESN3 AMBRA1 AMBRA1 TRIM8 TRIM8 WIPI1 WIPI1 SUPT5H SUPT5H ENSCAFP00000063173 ENSCAFP00000063173 TRIML1 TRIML1 HIF1A HIF1A KAT5 KAT5 TMEM59 TMEM59 TFEB TFEB PIP4K2B PIP4K2B ENSCAFP00000049310 ENSCAFP00000049310 MAPK3-2 MAPK3-2 PRAF2 PRAF2 BECN1 BECN1 PAFAH1B2 PAFAH1B2 ZC3H12A ZC3H12A SESN2 SESN2 ATG2A ATG2A J9P7B7_CANLF J9P7B7_CANLF HMGB1 HMGB1 ATG101 ATG101 TSC2 TSC2 RNF152 RNF152 LOC609558 LOC609558 RUFY4 RUFY4 BNIP3 BNIP3 TRIM32 TRIM32 ATG13 ATG13 SPTLC2 SPTLC2 SNX7 SNX7 ENDOG ENDOG WDR24 WDR24 STK11 STK11 F1PXS7_CANLF F1PXS7_CANLF PRKAA2 PRKAA2 FLCN FLCN ADRB2 ADRB2 SMCR8 SMCR8 LARP1 LARP1 MAPK3 MAPK3 CALCOCO2 CALCOCO2 VPS13D VPS13D HTT HTT FYCO1 FYCO1 SIRT1 SIRT1 BTNL9 BTNL9 SNX4 SNX4 BAG3 BAG3 TRIM27 TRIM27 SH3BP4 SH3BP4 IRF9 IRF9 RAB3GAP2 RAB3GAP2 TRIM38 TRIM38 NPRL2 NPRL2 LRRK2 LRRK2 NOD2 NOD2 MTDH MTDH TP53INP1 TP53INP1 TPCN1 TPCN1 RIPK2 RIPK2 PLEKHF1 PLEKHF1 TP53INP2 TP53INP2 TRIML2 TRIML2 ULK1 ULK1 TRIM34 TRIM34 DCN DCN FOXO1 FOXO1 STING1 STING1 TRIM65 TRIM65 GSK3A GSK3A RALB RALB OPTN OPTN PIP4K2A PIP4K2A WAC WAC FOXO3 FOXO3 SCOC SCOC CCNY CCNY NOD1 NOD1 SNX30 SNX30 SPTLC1 SPTLC1 KDR KDR FBXO7 FBXO7 C11H9orf72 C11H9orf72 HMOX1 HMOX1 DAPK1 DAPK1 IL4 IL4 IFNG IFNG PIP4K2C PIP4K2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UFL1UFM1 specific ligase 1. (791 aa)
TBK1TANK binding kinase 1. (772 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (744 aa)
SNX18Sorting nexin 18. (849 aa)
DEPDC5DEP domain containing 5. (1646 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (464 aa)
ENSCAFP00000050634Uncharacterized protein. (501 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
TRIM6Uncharacterized protein. (487 aa)
SESN1Sestrin 1. (658 aa)
ENSCAFP00000053367Uncharacterized protein. (82 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (743 aa)
TRIM13Tripartite motif containing 13. (455 aa)
PINK1PTEN induced kinase 1. (558 aa)
ATF6Activating transcription factor 6. (676 aa)
SVIPUncharacterized protein. (59 aa)
MID2Midline 2. (761 aa)
ALKAL1RB1 inducible coiled-coil 1. (1610 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (988 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa)
TRIM68Tripartite motif containing 68. (485 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (369 aa)
SESN3Sestrin 3. (573 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
TRIM8Tripartite motif containing 8. (592 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (624 aa)
SUPT5HTranscription elongation factor SPT5. (1120 aa)
ENSCAFP00000063173Uncharacterized protein. (97 aa)
TRIML1Tripartite motif family like 1. (555 aa)
HIF1AUncharacterized protein. (823 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
TMEM59Transmembrane protein 59. (419 aa)
TFEBTranscription factor EB. (566 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (441 aa)
ENSCAFP00000049310Uncharacterized protein. (176 aa)
MAPK3-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRAF2WD repeat domain 45. (403 aa)
BECN1Beclin 1. (471 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (280 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
SESN2Sestrin 2. (485 aa)
ATG2AAutophagy related 2A. (1936 aa)
J9P7B7_CANLFUncharacterized protein. (187 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (240 aa)
ATG101Autophagy related 101. (269 aa)
TSC2TSC complex subunit 2. (1783 aa)
RNF152Ring finger protein 152. (203 aa)
LOC609558Uncharacterized protein. (157 aa)
RUFY4RUN and FYVE domain containing 4. (664 aa)
BNIP3BCL2 interacting protein 3. (354 aa)
TRIM32Tripartite motif containing 32. (655 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (610 aa)
SNX7Sorting nexin 7. (390 aa)
ENDOGEndonuclease G. (439 aa)
WDR24WD repeat domain 24. (735 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
F1PXS7_CANLFProtein kinase domain-containing protein. (232 aa)
PRKAA2Non-specific serine/threonine protein kinase. (532 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (748 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (422 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
LARP1La ribonucleoprotein domain family member 1. (1069 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (502 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4325 aa)
HTTHuntingtin. (3130 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1459 aa)
SIRT1Sirtuin 1. (745 aa)
BTNL9Butyrophilin like 9. (541 aa)
SNX4Sorting nexin 4. (433 aa)
BAG3BCL2 associated athanogene 3. (579 aa)
TRIM27Tripartite motif containing 27. (462 aa)
SH3BP4SH3 domain binding protein 4. (962 aa)
IRF9Uncharacterized protein. (1136 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1540 aa)
TRIM38Tripartite motif containing 38. (462 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NOD2Uncharacterized protein. (1013 aa)
MTDHMetadherin. (631 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
TPCN1Two pore segment channel 1. (819 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (465 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
TRIML2Tripartite motif family like 2. (443 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1004 aa)
TRIM34Uncharacterized protein. (487 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
FOXO1Forkhead box O1. (654 aa)
STING1Transmembrane protein 173. (375 aa)
TRIM65Tripartite motif containing 65. (460 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
RALBRAS like proto-oncogene B. (206 aa)
OPTNOptineurin. (608 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
WACWW domain-containing protein. (599 aa)
FOXO3Forkhead box O3. (671 aa)
SCOCShort coiled-coil protein. (122 aa)
CCNYCyclin Y; Belongs to the cyclin family. (332 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (964 aa)
SNX30Sorting nexin family member 30. (446 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
FBXO7F-box protein 7. (523 aa)
C11H9orf72Chromosome 11 C9orf72 homolog. (481 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (352 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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