(5 nodes) Transition between fast and slow fiber network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	MYH6	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
	TNNC1	Troponin C1, slow skeletal and cardiac type. (303 aa)
	ACTN3	Actinin alpha 3. (1061 aa)
	TNNI1	Troponin I1, slow skeletal type. (270 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	MYH6	ENSCAFP00000018519	ENSCAFP00000053932	Actinin alpha 3.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.569
ACTN3	TNNC1	ENSCAFP00000018519	ENSCAFP00000045326	Actinin alpha 3.	Troponin C1, slow skeletal and cardiac type.	0.629
ACTN3	TNNI1	ENSCAFP00000018519	ENSCAFP00000015880	Actinin alpha 3.	Troponin I1, slow skeletal type.	0.698
MYH6	ACTN3	ENSCAFP00000053932	ENSCAFP00000018519	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Actinin alpha 3.	0.569
MYH6	TNNC1	ENSCAFP00000053932	ENSCAFP00000045326	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Troponin C1, slow skeletal and cardiac type.	0.474
MYH6	TNNI1	ENSCAFP00000053932	ENSCAFP00000015880	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Troponin I1, slow skeletal type.	0.783
TNNC1	ACTN3	ENSCAFP00000045326	ENSCAFP00000018519	Troponin C1, slow skeletal and cardiac type.	Actinin alpha 3.	0.629
TNNC1	MYH6	ENSCAFP00000045326	ENSCAFP00000053932	Troponin C1, slow skeletal and cardiac type.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.474
TNNC1	TNNI1	ENSCAFP00000045326	ENSCAFP00000015880	Troponin C1, slow skeletal and cardiac type.	Troponin I1, slow skeletal type.	0.929
TNNI1	ACTN3	ENSCAFP00000015880	ENSCAFP00000018519	Troponin I1, slow skeletal type.	Actinin alpha 3.	0.698
TNNI1	MYH6	ENSCAFP00000015880	ENSCAFP00000053932	Troponin I1, slow skeletal type.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.783
TNNI1	TNNC1	ENSCAFP00000015880	ENSCAFP00000045326	Troponin I1, slow skeletal type.	Troponin C1, slow skeletal and cardiac type.	0.929