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| | THPO | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (352 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (648 aa) |
| | STAT2 | Signal transducer and activator of transcription. (844 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (558 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (475 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (650 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | LY6G5B | Lymphocyte antigen 6 family member G5B. (200 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | IRF1 | Interferon regulatory factor 1. (437 aa) |
| | TNFRSF13C | TNF receptor superfamily member 13C. (286 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa) |
| | IL2RB | Fibronectin type-III domain-containing protein. (556 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (902 aa) |
| | IRF5 | Interferon regulatory factor 5. (605 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa) |
| | IFNK | Interferon kappa. (209 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (653 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). (372 aa) |
| | CCL19 | C-C motif chemokine. (115 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (582 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (557 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (578 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (595 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | F1PM66_CANLF | Ig-like domain-containing protein. (420 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa) |
| | CSF3R | Colony stimulating factor 3 receptor. (840 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | IRF3 | Interferon regulatory factor 3. (281 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | FOXO3 | Forkhead box O3. (671 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (560 aa) |
| | CCR4 | C-C chemokine receptor type 4; High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity). (360 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (326 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa) |
| | IL17RE | Interleukin 17 receptor E. (668 aa) |
| | ACKR2 | Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (1029 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | NMI | N-myc and STAT interactor. (308 aa) |
| | ACTN4 | Actinin alpha 4. (1163 aa) |
| | IL5RA | Interleukin 5 receptor subunit alpha. (420 aa) |
| | GFRA4 | GDNF family receptor alpha 4. (274 aa) |
| | ACKR4 | Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa) |
| | F6Y518_CANLF | IRF-3 domain-containing protein. (90 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | IL31RA | Interleukin 31 receptor A. (728 aa) |
| | KRT18 | IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | IL36B | Interleukin-1. (164 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (311 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa) |
| | IL17RD | Interleukin 17 receptor D. (594 aa) |
| | DOK1 | Docking protein 1. (483 aa) |
| | IL7 | Interleukin 7. (155 aa) |
| | SH2B3 | SH2B adaptor protein 3. (586 aa) |
| | CX3CL1 | Chemokine (C-X3-C motif) ligand 1. (437 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (374 aa) |
| | LOC609830 | Uncharacterized protein. (569 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (715 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (466 aa) |
| | CCL20 | C-C motif chemokine ligand 20. (97 aa) |
| | RABGEF1 | RAB guanine nucleotide exchange factor 1. (784 aa) |
| | CRLF2 | Cytokine receptor like factor 2. (373 aa) |
| | CSF2RA | Colony stimulating factor 2 receptor alpha subunit. (576 aa) |
| | IL3RA | Interleukin 3 receptor subunit alpha. (489 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, lead [...] (362 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | OSM | Oncostatin M. (247 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (449 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | DUOX2 | Dual oxidase 2. (1519 aa) |
| | DUOX1 | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1551 aa) |
| | CCRL2 | C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (349 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa) |
| | CCR2 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | CCR3 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (360 aa) |
| | CXCR6 | C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa) |
| | CCR9 | Chemokine C-C motif receptor 9; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (685 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (200 aa) |
| | TNFSF18 | TNF superfamily member 18. (190 aa) |
| | CXCR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | CXCR2 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (358 aa) |
| | CRLF1 | Cytokine receptor like factor 1. (383 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9. (299 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (732 aa) |
| | PLVAP | Plasmalemma vesicle associated protein. (482 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | FAS | Fas cell surface death receptor. (734 aa) |
| | PLP2 | MARVEL domain-containing protein. (145 aa) |
| | IL17RA | Interleukin 17 receptor A. (866 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (780 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (283 aa) |
| | CXCR3 | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (368 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | EPOR | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (508 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (793 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | CCL16 | C-C motif chemokine. (117 aa) |
| | CCL14 | C-C motif chemokine. (94 aa) |
| | CCL8 | C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). (99 aa) |
| | CCL25 | C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (164 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (858 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | OSMR | Oncostatin M receptor. (968 aa) |
| | IL7R | Interleukin 7 receptor. (456 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (197 aa) |
| | F1PXS7_CANLF | Protein kinase domain-containing protein. (232 aa) |
| | EBI3 | Epstein-Barr virus induced 3. (226 aa) |
| | TNFRSF4 | TNF receptor superfamily member 4. (385 aa) |
| | TNFRSF18 | TNF receptor superfamily member 18. (322 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | NOTCH1 | Notch receptor 1. (2565 aa) |
| | LOC611642 | Fibronectin type-III domain-containing protein. (505 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (427 aa) |
| | TRAF1 | TNF receptor associated factor 1. (368 aa) |
| | CXCL10 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] (98 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (535 aa) |
| | CCL13 | C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family. (97 aa) |
| | ILK | Integrin linked kinase. (452 aa) |
| | IL15RA | Interleukin 15 receptor subunit alpha. (251 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | CCR10 | C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa) |
| | CXCL6 | C-X-C motif chemokine. (115 aa) |
| | CXCL13 | C-X-C motif chemokine. (110 aa) |
| | ACKR1 | Atypical chemokine receptor 1. (331 aa) |
| | TNFSF13B | Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (370 aa) |
| | CD70 | CD70 molecule; Belongs to the tumor necrosis factor family. (199 aa) |
| | J9NRS1_CANLF | SCY domain-containing protein. (213 aa) |
| | LOC484306 | Uncharacterized protein. (616 aa) |
| | CCL22 | C-C motif chemokine. (93 aa) |
| | CXCL12 | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa) |
| | EDA | Ectodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa) |
| | GFRAL | GDNF family receptor alpha like. (560 aa) |
| | IL21R | Interleukin 21 receptor. (543 aa) |
| | RHEX | Regulator of hemoglobinization and erythroid cell expansion. (170 aa) |
| | JAGN1 | Jagunal homolog 1. (183 aa) |
| | GFRA3 | GDNF family receptor alpha 3. (426 aa) |
| | GFRA2 | GDNF family receptor alpha 2. (597 aa) |
| | TNFRSF17 | TNF receptor superfamily member 17. (175 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | LOC100686341 | Fibronectin type-III domain-containing protein. (402 aa) |
| | EREG | Epiregulin. (160 aa) |
| | YAP1 | Yes associated protein 1. (325 aa) |
| | CCR8 | C-C motif chemokine receptor 8. (118 aa) |
| | IL17RB | Interleukin 17 receptor B. (476 aa) |
| | PPBP | SCY domain-containing protein. (118 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | IL17REL | Interleukin 17 receptor E like. (544 aa) |
| | LOC480601 | SCY domain-containing protein. (94 aa) |
| | CCL26 | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils. (94 aa) |
| | IL1F10 | Interleukin-1. (177 aa) |
| | CD300LF | IG domain-containing protein. (310 aa) |
| | J9P5T3_CANLF | MARVEL domain-containing protein. (176 aa) |
| | IL2RG | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa) |
| | IL37 | Interleukin-1. (288 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | CX3CR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | MT3 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa) |
| | IFNLR1 | Interferon lambda receptor 1. (502 aa) |
| | SH2B2 | SH2B adaptor protein 2. (626 aa) |
| | CCL23 | SCY domain-containing protein. (119 aa) |
| | ENSCAFP00000043591 | Uncharacterized protein. (176 aa) |
| | IL4R | Interleukin 4 receptor. (835 aa) |
| | JAK2 | Janus kinase 2. (1407 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (470 aa) |
| | IL17A | Interleukin 17A. (156 aa) |
| | IFI27L2 | Uncharacterized protein. (110 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | IFNGR2 | Uncharacterized protein. (435 aa) |
| | CD74 | CD74 molecule. (272 aa) |
| | CCL4 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (97 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | ADIPOR2 | Adiponectin receptor 2. (559 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (629 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | STAT6 | Signal transducer and activator of transcription. (927 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa) |
| | LYN | Tyrosine-protein kinase. (566 aa) |
| | WBP1L | WW domain binding protein 1 like. (365 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (750 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (256 aa) |
| | LOC100687928 | Interferon alpha-1/2. (187 aa) |
| | LIFR | Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1157 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | MAPK3-2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | CCL17 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (195 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (560 aa) |
| | CCL1 | C-C motif chemokine. (94 aa) |
| | LOC478404 | Uncharacterized protein. (528 aa) |
| | TREX1 | Three prime repair exonuclease 1. (373 aa) |
| | ENSCAFP00000049600 | Uncharacterized protein. (108 aa) |
| | IFNAR1 | Uncharacterized protein. (572 aa) |
| | LOC100683123 | Interferon alpha-1/2-like. (187 aa) |
| | TYK2 | Tyrosine-protein kinase. (1173 aa) |
| | CD44 | CD44 antigen. (859 aa) |
| | STAT3 | Signal transducer and activator of transcription. (793 aa) |
| | STAT4 | Signal transducer and activator of transcription. (772 aa) |
| | ENSCAFP00000051285 | Ig-like domain-containing protein. (201 aa) |
| | ENSCAFP00000051286 | Uncharacterized protein. (215 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1029 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (523 aa) |
| | LOC100685213 | Interferon alpha-1/2. (187 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (292 aa) |
| | ENSCAFP00000053409 | SEFIR domain-containing protein. (199 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa) |
| | CSF1R | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa) |
| | LOC100688084 | Interferon alpha-1/2. (187 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (482 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | CCR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (849 aa) |
| | LOC611446 | Uncharacterized protein. (651 aa) |
| | SYK | Tyrosine-protein kinase. (699 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (718 aa) |
| | CXCL11 | C-X-C motif chemokine ligand 11. (92 aa) |
| | IL36G | Interleukin 36 gamma. (194 aa) |
| | LOC100682977 | Interferon alpha-1/2-like. (187 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (399 aa) |
| | IL34 | Interleukin 34. (261 aa) |
| | COQ8B | Coenzyme Q8B. (704 aa) |
| | IL13RA2 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily. (406 aa) |
| | LOC487739 | Uncharacterized protein. (363 aa) |
| | LOC100683265 | Interferon alpha-1/2-like. (187 aa) |
| | GHR | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). (645 aa) |
| | TFF2 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). (170 aa) |
| | BBS4 | Ariadne RBR E3 ubiquitin protein ligase 1. (908 aa) |
| | IFNAR2 | Uncharacterized protein. (522 aa) |
| | ENSCAFP00000058087 | IF rod domain-containing protein; Belongs to the intermediate filament family. (218 aa) |
| | COMMD7 | COMM domain containing 7. (259 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (746 aa) |
| | ENSCAFP00000059302 | Uncharacterized protein. (151 aa) |
| | CSF1 | Colony stimulating factor 1. (587 aa) |
| | IL17F | Interleukin 17F. (196 aa) |
| | LOC100688005 | Interferon alpha-1/2-like. (187 aa) |
| | ENSCAFP00000060619 | Uncharacterized protein. (124 aa) |
| | CIB1 | Calcium and integrin binding 1. (234 aa) |
| | SLC27A1 | Solute carrier family 27 member 1. (653 aa) |
| | CCL24 | C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (232 aa) |
| | ENSCAFP00000062374 | IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa) |
| | TOLLIP | Toll interacting protein. (281 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | LOC100683045 | Interferon alpha-1/2-like. (187 aa) |
| | IL6ST | Uncharacterized protein. (954 aa) |
| | LOC100687778 | Interferon alpha-1/2-like. (187 aa) |
| | STK39 | Serine/threonine kinase 39. (555 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (144 aa) |
| | CCL3 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (159 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | IL17RC | Interleukin 17 receptor C. (717 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
| | LOC484309 | Uncharacterized protein. (552 aa) |
| | TXNDC17 | Thioredoxin domain containing 17. (131 aa) |
