STRINGSTRING
CLEC12B CLEC12B SLAMF1 SLAMF1 NLRX1 NLRX1 TRIM27 TRIM27 C4BPA C4BPA CR2 CR2 IL10 IL10 SUSD4 SUSD4 ANXA1 ANXA1 IFNB1 IFNB1 IL4 IL4 ENPP3 ENPP3 USP15 USP15 TNFAIP3 TNFAIP3 HLX HLX CD160 CD160 RABGEF1 RABGEF1 CD96 CD96 HLA-DQB1 HLA-DQB1 CSMD3 CSMD3 IRAK3 IRAK3 ATG12 ATG12 STAT2 STAT2 PARP3 PARP3 NOD2 NOD2 TRAFD1 TRAFD1 SAMHD1 SAMHD1 IL20RB IL20RB CNOT7 CNOT7 SPINK5 SPINK5 NLRP6 NLRP6 NCKAP1L NCKAP1L METTL3 METTL3 NMI NMI FOXJ1 FOXJ1 MKRN2 MKRN2 IL2 IL2 ATG5 ATG5 IL4I1 IL4I1 TYRO3 TYRO3 ENSCAFP00000055589 ENSCAFP00000055589 PTPRC PTPRC SERPING1 SERPING1 LOXL3 LOXL3 CR1L CR1L AHR AHR TREM2 TREM2 INS INS VSIG4 VSIG4 ENSCAFP00000049600 ENSCAFP00000049600 TREX1 TREX1 SAMSN1 SAMSN1 NLRC5 NLRC5 STAT6 STAT6 HFE HFE TTLL12 TTLL12 CD84 CD84 ZC3H12A ZC3H12A PPP3CB PPP3CB PTPN6 PTPN6 ENSCAFP00000043339 ENSCAFP00000043339 J9P9G4_CANLF J9P9G4_CANLF SOCS5 SOCS5 E2R735_CANLF E2R735_CANLF ARG2 ARG2 INPP5D INPP5D CD55 CD55 ENSCAFP00000059957 ENSCAFP00000059957 BCR BCR LOC484865 LOC484865 RC3H2 RC3H2 NDFIP1 NDFIP1 PSMA1 PSMA1 J9P915_CANLF J9P915_CANLF CD59 CD59 J9P3Z4_CANLF J9P3Z4_CANLF LOC102152879 LOC102152879 IL1RL1 IL1RL1 GPR17 GPR17 YTHDF3 YTHDF3 J9NYK3_CANLF J9NYK3_CANLF C4BPB C4BPB SELENOS SELENOS J9JHW4_CANLF J9JHW4_CANLF KLRD1 KLRD1 LOC609365 LOC609365 YTHDF2 YTHDF2 FOXF1 FOXF1 ISG15 ISG15 CACTIN CACTIN SMAD7 SMAD7 PTPN2 PTPN2 THOC1 THOC1 HAVCR1 HAVCR1 ADAR ADAR ZBTB7B ZBTB7B DCST1 DCST1 TBX21 TBX21 IL27RA IL27RA ALOX12 ALOX12 FOXP3 FOXP3 DHX58 DHX58 LYAR LYAR OTOP1 OTOP1 MUL1 MUL1 COL3A1 COL3A1 RC3H1 RC3H1 LOC102156626 LOC102156626 GRN GRN BCL6 BCL6 DUSP10 DUSP10 PDCD1 PDCD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLEC12BC-type lectin domain family 12 member B. (277 aa)
SLAMF1Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] (342 aa)
NLRX1NLR family member X1. (975 aa)
TRIM27Tripartite motif containing 27. (462 aa)
C4BPAComplement component 4 binding protein alpha. (606 aa)
CR2Uncharacterized protein. (1337 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
SUSD4Sushi domain containing 4. (781 aa)
ANXA1Annexin. (345 aa)
IFNB1Interferon-beta. (186 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (1109 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
HLXH2.0 like homeobox. (448 aa)
CD160CD160 molecule. (277 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (784 aa)
CD96CD96 molecule. (568 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
CSMD3CUB and Sushi multiple domains 3. (3707 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (650 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
NOD2Uncharacterized protein. (1013 aa)
TRAFD1TRAF-type zinc finger domain containing 1. (583 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1063 aa)
NLRP6NLR family pyrin domain containing 6. (911 aa)
NCKAP1LNCK associated protein 1 like. (1133 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
NMIN-myc and STAT interactor. (308 aa)
FOXJ1Forkhead box J1. (422 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IL4I1Interleukin 4 induced 1. (579 aa)
TYRO3TYRO3 protein tyrosine kinase. (902 aa)
ENSCAFP00000055589zf-LYAR domain-containing protein. (321 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1385 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (497 aa)
LOXL3Lysyl oxidase like 3. (834 aa)
CR1LUncharacterized protein. (555 aa)
AHRAryl hydrocarbon receptor. (853 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (523 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
VSIG4V-set and immunoglobulin domain containing 4. (403 aa)
ENSCAFP00000049600Uncharacterized protein. (108 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (460 aa)
NLRC5NLR family CARD domain containing 5. (1859 aa)
STAT6Signal transducer and activator of transcription. (927 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (504 aa)
TTLL12Tubulin tyrosine ligase like 12. (775 aa)
CD84CD84 molecule. (342 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (620 aa)
ENSCAFP00000043339Uncharacterized protein. (532 aa)
J9P9G4_CANLFProteasome subunit alpha type. (263 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
E2R735_CANLFAmino_oxidase domain-containing protein. (477 aa)
ARG2Arginase. (384 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
CD55CD55 molecule. (405 aa)
ENSCAFP00000059957Proteasome endopeptidase complex. (243 aa)
BCRBCR activator of RhoGEF and GTPase. (1262 aa)
LOC484865C-type lectin domain-containing protein. (224 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
NDFIP1Nedd4 family interacting protein 1. (225 aa)
PSMA1Proteasome subunit alpha type. (267 aa)
J9P915_CANLFProteasome endopeptidase complex; Belongs to the peptidase T1A family. (266 aa)
CD59CD59 molecule. (123 aa)
J9P3Z4_CANLFUncharacterized protein. (153 aa)
LOC102152879Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (308 aa)
IL1RL1Interleukin 1 receptor like 1. (557 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
J9NYK3_CANLFUncharacterized protein. (106 aa)
C4BPBComplement component 4 binding protein beta. (255 aa)
SELENOSSelenoprotein S. (189 aa)
J9JHW4_CANLFProteasome endopeptidase complex; Belongs to the peptidase T1A family. (263 aa)
KLRD1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
LOC609365Uncharacterized protein. (395 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
FOXF1Forkhead box F1. (354 aa)
ISG15ISG15 ubiquitin like modifier. (168 aa)
CACTINCactin, spliceosome C complex subunit. (752 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (408 aa)
THOC1THO complex 1. (657 aa)
HAVCR1Ig-like domain-containing protein. (304 aa)
ADARAdenosine deaminase RNA specific. (929 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (685 aa)
DCST1DC-STAMP domain containing 1. (706 aa)
TBX21T-box transcription factor 21. (535 aa)
IL27RAInterleukin 27 receptor subunit alpha. (780 aa)
ALOX12Arachidonate 15-lipoxygenase. (664 aa)
FOXP3Forkhead box P3. (452 aa)
DHX58DExH-box helicase 58. (678 aa)
LYARLy1 antibody reactive. (380 aa)
OTOP1Otopetrin 1. (379 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (483 aa)
COL3A1Collagen type III alpha 1 chain. (1539 aa)
RC3H1Ring finger and CCCH-type domains 1. (1132 aa)
LOC102156626Uncharacterized protein. (312 aa)
GRNGranulin precursor. (580 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
PDCD1Programmed cell death 1. (288 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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