STRINGSTRING
FRS2 FRS2 PI16 PI16 DLL1 DLL1 GSK3A GSK3A BHLHA15 BHLHA15 MSX1 MSX1 MYOCD MYOCD NOTCH1 NOTCH1 PLPP7 PLPP7 FZD7 FZD7 TMEM119 TMEM119 EZH2 EZH2 CCN3 CCN3 NKX2-5 NKX2-5 HDAC5 HDAC5 BMP2 BMP2 TRIM72 TRIM72 SMAD4 SMAD4 SOX6 SOX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (458 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
BHLHA15Basic helix-loop-helix family member a15. (187 aa)
MSX1Msh homeobox 1. (276 aa)
MYOCDMyocardin. (983 aa)
NOTCH1Notch receptor 1. (2565 aa)
PLPP7Phospholipid phosphatase 7 (inactive). (271 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa)
TMEM119Transmembrane protein 119. (336 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (842 aa)
CCN3Cellular communication network factor 3. (353 aa)
NKX2-5Transcription factor NKX2.5. (322 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1139 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
TRIM72Tripartite motif containing 72. (481 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SOX6SRY-box 6. (889 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.