(24 nodes) Positive regulation of protein deacetylation network (Canis lupus familiaris)

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Your Input:
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	SIRT1	Sirtuin 1. (745 aa)
	BRMS1	BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
	NDN	Necdin, MAGE family member. (325 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	DYRK1A	Dual specificity tyrosine phosphorylation regulated kinase 1A. (762 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	RRP8	Ribosomal RNA processing 8. (664 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (380 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
	PINK1	PTEN induced kinase 1. (558 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa)
	ENSCAFP00000056794	Uncharacterized protein. (226 aa)
	C12H6orf89	Chromosome 12 C6orf89 homolog. (385 aa)
	SAP30BP	SAP30 binding protein. (322 aa)
	PRKD2	Protein kinase D2. (1018 aa)
	NNMT	Nicotinamide N-methyltransferase. (264 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (685 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (423 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	IFNG	ENSCAFP00000020491	ENSCAFP00000000588	B-cell lymphoma 6 protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.554
BCL6	SIRT1	ENSCAFP00000020491	ENSCAFP00000019617	B-cell lymphoma 6 protein.	Sirtuin 1.	0.529
BCL6	TP53	ENSCAFP00000020491	ENSCAFP00000064590	B-cell lymphoma 6 protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.408
BRMS1	ING2	ENSCAFP00000018831	ENSCAFP00000011661	BRMS1 transcriptional repressor and anoikis regulator.	Inhibitor of growth protein.	0.678
CTBP1	SIRT1	ENSCAFP00000024542	ENSCAFP00000019617	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Sirtuin 1.	0.430
DYRK1A	TP53	ENSCAFP00000014403	ENSCAFP00000064590	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.482
ENSCAFP00000056794	ING2	ENSCAFP00000056794	ENSCAFP00000011661	Uncharacterized protein.	Inhibitor of growth protein.	0.678
IFNG	BCL6	ENSCAFP00000000588	ENSCAFP00000020491	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	B-cell lymphoma 6 protein.	0.554
IFNG	SIRT1	ENSCAFP00000000588	ENSCAFP00000019617	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Sirtuin 1.	0.482
IFNG	TP53	ENSCAFP00000000588	ENSCAFP00000064590	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.731
ING2	BRMS1	ENSCAFP00000011661	ENSCAFP00000018831	Inhibitor of growth protein.	BRMS1 transcriptional repressor and anoikis regulator.	0.678
ING2	ENSCAFP00000056794	ENSCAFP00000011661	ENSCAFP00000056794	Inhibitor of growth protein.	Uncharacterized protein.	0.678
LRRK2	PINK1	ENSCAFP00000014627	ENSCAFP00000057576	Leucine rich repeat kinase 2.	PTEN induced kinase 1.	0.614
NDN	TP53	ENSCAFP00000014880	ENSCAFP00000064590	Necdin, MAGE family member.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.683
NIPBL	SMARCA5	ENSCAFP00000040036	ENSCAFP00000011181	Nipped-B protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.	0.450
NNMT	SIRT1	ENSCAFP00000041155	ENSCAFP00000019617	Nicotinamide N-methyltransferase.	Sirtuin 1.	0.932
PINK1	LRRK2	ENSCAFP00000057576	ENSCAFP00000014627	PTEN induced kinase 1.	Leucine rich repeat kinase 2.	0.614
PINK1	SIRT1	ENSCAFP00000057576	ENSCAFP00000019617	PTEN induced kinase 1.	Sirtuin 1.	0.631
PRKD1	PRKD2	ENSCAFP00000058806	ENSCAFP00000047470	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Protein kinase D2.	0.901
PRKD2	PRKD1	ENSCAFP00000047470	ENSCAFP00000058806	Protein kinase D2.	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	0.901