STRINGSTRING
SNAI1 SNAI1 TGFB2 TGFB2 NSUN2 NSUN2 LDB1 LDB1 ALX4 ALX4 FZD3 FZD3 TRPC4AP TRPC4AP SOS1 SOS1 DLL1 DLL1 INTU INTU INHBA INHBA ZMPSTE24 ZMPSTE24 KRT27 KRT27 KRT25 KRT25 GORAB GORAB WNT10A WNT10A FGF7 FGF7 EDAR EDAR ZDHHC21 ZDHHC21 EXT1 EXT1 TP63 TP63 RELA RELA LGR5 LGR5 ENSCAFP00000065209 ENSCAFP00000065209 SAV1 SAV1 CD109 CD109 ERCC2 ERCC2 SMO SMO PUM2 PUM2 LGR4 LGR4 TNFRSF19 TNFRSF19 DLX3 DLX3 FST FST KDF1 KDF1 LDB2 LDB2 NGFR NGFR LRP4 LRP4 CELSR1 CELSR1 SOSTDC1 SOSTDC1 NOM1 NOM1 SOX18 SOX18 EDA EDA FGF10 FGF10 NF1 NF1 LHX2 LHX2 NOTCH1 NOTCH1 NSDHL NSDHL PIAS4 PIAS4 PLA2G10 PLA2G10 APCDD1 APCDD1 FOXN1 FOXN1 DSG1 DSG1 TMEM79 TMEM79 KRT26 KRT26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAI1Snail family transcriptional repressor 1. (263 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (780 aa)
LDB1LIM domain binding 1. (375 aa)
ALX4ALX homeobox 4. (414 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
INTUInturned planar cell polarity protein. (941 aa)
INHBAInhibin subunit beta A. (424 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
KRT27IF rod domain-containing protein; Belongs to the intermediate filament family. (446 aa)
KRT25IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
GORABGolgin, RAB6 interacting. (397 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FGF7Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa)
EDAREctodysplasin A receptor. (447 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (877 aa)
ENSCAFP00000065209SP-RING-type domain-containing protein. (185 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
CD109CD109 molecule. (1577 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
PUM2Pumilio RNA binding family member 2. (1053 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1040 aa)
TNFRSF19TNF receptor superfamily member 19. (432 aa)
DLX3Distal-less homeobox 3. (319 aa)
FSTFollistatin. (237 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
LDB2LIM domain binding 2. (385 aa)
NGFRNerve growth factor receptor. (429 aa)
LRP4LDL receptor related protein 4. (1953 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2716 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
NOM1Nucleolar protein with MIF4G domain 1. (825 aa)
SOX18SRY-box 18. (522 aa)
EDAEctodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
NF1Neurofibromin 1. (2784 aa)
LHX2LIM homeobox 2. (406 aa)
NOTCH1Notch receptor 1. (2565 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
PIAS4Protein inhibitor of activated STAT 4. (521 aa)
PLA2G10Phospholipase A(2). (153 aa)
APCDD1APC down-regulated 1. (515 aa)
FOXN1Forkhead box N1. (643 aa)
DSG1Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1353 aa)
TMEM79Transmembrane protein 79. (395 aa)
KRT26IF rod domain-containing protein; Belongs to the intermediate filament family. (464 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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