STRINGSTRING
LOC100856175 LOC100856175 IGSF22 IGSF22 SMN SMN TCAP TCAP ACTN2 ACTN2 CAPN3 CAPN3 CSRP3 CSRP3 HRC HRC BMP10 BMP10 FHL3 FHL3 ENSCAFP00000049249 ENSCAFP00000049249 C18H7orf57 C18H7orf57 CASQ2 CASQ2 ENSCAFP00000051866 ENSCAFP00000051866 FHL2 FHL2 FLNC FLNC DNAJB7 DNAJB7 NEBL NEBL MYOT MYOT DES DES CHORDC1 CHORDC1 PDLIM3 PDLIM3 TRIM13 TRIM13 ENSCAFP00000057453 ENSCAFP00000057453 KY KY NEXN NEXN DNAJB6 DNAJB6 TRIM54 TRIM54 SPHKAP SPHKAP PDLIM1 PDLIM1 C28H10orf71 C28H10orf71 SRI SRI TRIM59 TRIM59 SYNC SYNC LOC100855804 LOC100855804 E2R2S9_CANLF E2R2S9_CANLF SAMD13 SAMD13 UNC45B UNC45B MYOZ3 MYOZ3 ASB2 ASB2 ITGB1BP2 ITGB1BP2 FBXL22 FBXL22 PSEN1 PSEN1 PDLIM7 PDLIM7 LDB3 LDB3 E2QZE6_CANLF E2QZE6_CANLF MYOZ1 MYOZ1 SLC4A1 SLC4A1 MYPN MYPN ACTN3 ACTN3 MYOZ2 MYOZ2 SYNPO2 SYNPO2 CAPN9 CAPN9 DNAJB3 DNAJB3 XIRP2 XIRP2 GGPS1 GGPS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100856175Uncharacterized protein. (2851 aa)
IGSF22Immunoglobulin superfamily member 22. (1342 aa)
SMNSurvival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (323 aa)
TCAPTitin-cap. (210 aa)
ACTN2Actinin alpha 2. (894 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
HRCHistidine rich calcium binding protein. (763 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FHL3Four and a half LIM domains 3. (290 aa)
ENSCAFP00000049249Uncharacterized protein. (234 aa)
C18H7orf57Chromosome 18 C7orf57 homolog. (432 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (554 aa)
ENSCAFP00000051866Uncharacterized protein. (865 aa)
FHL2Four and a half LIM domains 2. (279 aa)
FLNCFilamin C. (2720 aa)
DNAJB7DnaJ heat shock protein family (Hsp40) member B7. (309 aa)
NEBLNebulette. (1017 aa)
MYOTMyotilin. (804 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (510 aa)
PDLIM3PDZ and LIM domain 3. (405 aa)
TRIM13Tripartite motif containing 13. (455 aa)
ENSCAFP00000057453PDZ domain-containing protein. (221 aa)
KYKyphoscoliosis peptidase. (722 aa)
NEXNNexilin F-actin binding protein. (881 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (336 aa)
TRIM54Tripartite motif containing 54. (429 aa)
SPHKAPSPHK1 interactor, AKAP domain containing. (1737 aa)
PDLIM1PDZ and LIM domain 1. (317 aa)
C28H10orf71Chromosome 28 C10orf71 homolog. (1423 aa)
SRISorcin. (348 aa)
TRIM59Tripartite motif containing 59. (404 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (472 aa)
LOC100855804Uncharacterized protein. (2797 aa)
E2R2S9_CANLFPDZ domain-containing protein. (257 aa)
SAMD13J domain-containing protein. (222 aa)
UNC45BUnc-45 myosin chaperone B. (945 aa)
MYOZ3Myozenin 3. (254 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (347 aa)
FBXL22Uncharacterized protein. (223 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa)
PDLIM7PDZ domain-containing protein. (269 aa)
LDB3LIM domain binding 3. (780 aa)
E2QZE6_CANLFJ domain-containing protein. (70 aa)
MYOZ1Calsarcin 2. (297 aa)
SLC4A1Anion exchange protein. (930 aa)
MYPNMyopalladin. (1322 aa)
ACTN3Actinin alpha 3. (1061 aa)
MYOZ2Myozenin 2. (264 aa)
SYNPO2Synaptopodin 2. (1262 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (692 aa)
DNAJB3J domain-containing protein. (238 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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