(15 nodes) Androgen biosynthesis, and Steroid hormone biosynthesis network (Ursus americanus)

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Your Input:
	STS	Steroid sulfatase. (602 aa)
	ENSUAMP00000008515	Uncharacterized protein. (148 aa)
	AKR1C8P	Aldo-keto reductase family 1 member C8, pseudogene. (324 aa)
	ENSUAMP00000012528	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	SULT2B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (333 aa)
	SDR9C7	Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	SRD5A3	Steroid 5 alpha-reductase 3. (318 aa)
	ENSUAMP00000027938	Uncharacterized protein. (110 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
	ENSUAMP00000032699	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	HSD17B2	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (380 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (356 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C8P	CYP11A1	ENSUAMP00000008587	ENSUAMP00000031921	Aldo-keto reductase family 1 member C8, pseudogene.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.523
AKR1C8P	CYP17A1	ENSUAMP00000008587	ENSUAMP00000035104	Aldo-keto reductase family 1 member C8, pseudogene.	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.952
AKR1C8P	CYP21A2	ENSUAMP00000008587	ENSUAMP00000029173	Aldo-keto reductase family 1 member C8, pseudogene.	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.641
AKR1C8P	ENSUAMP00000008515	ENSUAMP00000008587	ENSUAMP00000008515	Aldo-keto reductase family 1 member C8, pseudogene.	Uncharacterized protein.	0.894
AKR1C8P	ENSUAMP00000012528	ENSUAMP00000008587	ENSUAMP00000012528	Aldo-keto reductase family 1 member C8, pseudogene.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.951
AKR1C8P	ENSUAMP00000027938	ENSUAMP00000008587	ENSUAMP00000027938	Aldo-keto reductase family 1 member C8, pseudogene.	Uncharacterized protein.	0.894
AKR1C8P	ENSUAMP00000032699	ENSUAMP00000008587	ENSUAMP00000032699	Aldo-keto reductase family 1 member C8, pseudogene.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.962
AKR1C8P	HSD17B2	ENSUAMP00000008587	ENSUAMP00000033531	Aldo-keto reductase family 1 member C8, pseudogene.	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.951
AKR1C8P	SDR9C7	ENSUAMP00000008587	ENSUAMP00000013501	Aldo-keto reductase family 1 member C8, pseudogene.	Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.819
AKR1C8P	SRD5A1	ENSUAMP00000008587	ENSUAMP00000032354	Aldo-keto reductase family 1 member C8, pseudogene.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.965
AKR1C8P	SRD5A2	ENSUAMP00000008587	ENSUAMP00000014418	Aldo-keto reductase family 1 member C8, pseudogene.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.959
AKR1C8P	SRD5A3	ENSUAMP00000008587	ENSUAMP00000023140	Aldo-keto reductase family 1 member C8, pseudogene.	Steroid 5 alpha-reductase 3.	0.961
AKR1C8P	STS	ENSUAMP00000008587	ENSUAMP00000007893	Aldo-keto reductase family 1 member C8, pseudogene.	Steroid sulfatase.	0.948
AKR1C8P	SULT2B1	ENSUAMP00000008587	ENSUAMP00000013248	Aldo-keto reductase family 1 member C8, pseudogene.	Sulfotransferase; Belongs to the sulfotransferase 1 family.	0.946
CYP11A1	AKR1C8P	ENSUAMP00000031921	ENSUAMP00000008587	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Aldo-keto reductase family 1 member C8, pseudogene.	0.523
CYP11A1	CYP17A1	ENSUAMP00000031921	ENSUAMP00000035104	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.971
CYP11A1	CYP21A2	ENSUAMP00000031921	ENSUAMP00000029173	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.969
CYP11A1	ENSUAMP00000008515	ENSUAMP00000031921	ENSUAMP00000008515	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein.	0.735
CYP11A1	ENSUAMP00000027938	ENSUAMP00000031921	ENSUAMP00000027938	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein.	0.735
CYP11A1	ENSUAMP00000032699	ENSUAMP00000031921	ENSUAMP00000032699	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.991