STRINGSTRING
ENSUAMP00000001245 ENSUAMP00000001245 AXIN2 AXIN2 SCUBE2 SCUBE2 ENSUAMP00000003016 ENSUAMP00000003016 RARG RARG ENSUAMP00000004452 ENSUAMP00000004452 ENSUAMP00000004460 ENSUAMP00000004460 SERPINH1 SERPINH1 FGF9 FGF9 TWSG1 TWSG1 ENSUAMP00000006989 ENSUAMP00000006989 EXT2 EXT2 NPPC NPPC COL3A1 COL3A1 WNT2B WNT2B ENSUAMP00000009377 ENSUAMP00000009377 GDF5 GDF5 ATF2 ATF2 CYTL1 CYTL1 CCN3 CCN3 CCN2 CCN2 TGFB1 TGFB1 EXT1 EXT1 ENSUAMP00000014408 ENSUAMP00000014408 RB1 RB1 ENSUAMP00000015842 ENSUAMP00000015842 MEF2D MEF2D ENSUAMP00000017173 ENSUAMP00000017173 SLC39A14 SLC39A14 MEX3C MEX3C HOXA11 HOXA11 ECM1 ECM1 ENSUAMP00000019308 ENSUAMP00000019308 ENSUAMP00000019709 ENSUAMP00000019709 SMPD3 SMPD3 ENSUAMP00000020386 ENSUAMP00000020386 RUNX1 RUNX1 BMP2 BMP2 MATN1 MATN1 ENSUAMP00000023668 ENSUAMP00000023668 ARID5A ARID5A GPLD1 GPLD1 SULF2 SULF2 ENSUAMP00000025690 ENSUAMP00000025690 ENSUAMP00000025721 ENSUAMP00000025721 SOX9 SOX9 IMPAD1 IMPAD1 LTBP3 LTBP3 OSR2 OSR2 SULF1 SULF1 ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 BMP4 BMP4 MEF2C MEF2C ANXA6 ANXA6 FGF18 FGF18 GLI3 GLI3 ENSUAMP00000032843 ENSUAMP00000032843 BMPR1B BMPR1B PTH1R PTH1R HIF1A HIF1A OSR1 OSR1 WNT10B WNT10B IFT80 IFT80 BMPR1A BMPR1A COMP COMP BMPR2 BMPR2 TRIP11 TRIP11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000001245CTF/NF-I domain-containing protein. (195 aa)
AXIN2Axin 2. (843 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1071 aa)
ENSUAMP00000003016Uncharacterized protein. (461 aa)
RARGRetinoic acid receptor gamma. (458 aa)
ENSUAMP00000004452annotation not available (461 aa)
ENSUAMP00000004460Runt domain-containing protein. (278 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (449 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
ENSUAMP00000006989CTF/NF-I domain-containing protein. (213 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
NPPCNatriuretic peptide C. (126 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
ENSUAMP00000009377Uncharacterized protein. (170 aa)
GDF5Growth differentiation factor 5. (499 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CYTL1Cytokine like 1. (135 aa)
CCN3Cellular communication network factor 3. (353 aa)
CCN2Cellular communication network factor 2. (349 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000014408RunxI domain-containing protein. (143 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ENSUAMP00000015842Uncharacterized protein. (82 aa)
MEF2DMyocyte enhancer factor 2D. (515 aa)
ENSUAMP00000017173Nexin_C domain-containing protein. (161 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
MEX3CMex-3 RNA binding family member C. (496 aa)
HOXA11Homeobox A11. (313 aa)
ECM1Extracellular matrix protein 1. (422 aa)
ENSUAMP00000019308Uncharacterized protein. (459 aa)
ENSUAMP00000019709Uncharacterized protein. (915 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
ENSUAMP00000020386Uncharacterized protein. (460 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (444 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
MATN1Matrilin 1. (497 aa)
ENSUAMP00000023668Uncharacterized protein. (113 aa)
ARID5AAT-rich interaction domain 5A. (437 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (726 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
ENSUAMP00000025690Runt domain-containing protein. (196 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
SOX9SRY-box transcription factor 9. (484 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1169 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ANXA6Annexin. (673 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
GLI3GLI family zinc finger 3. (1413 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (594 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IFT80Intraflagellar transport 80. (768 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
TRIP11Thyroid hormone receptor interactor 11. (1978 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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