STRINGSTRING
TDRKH TDRKH OTX1 OTX1 CTNNBIP1 CTNNBIP1 ENSUAMP00000019152 ENSUAMP00000019152 ENSUAMP00000019144 ENSUAMP00000019144 TDRD6 TDRD6 CELSR1 CELSR1 KDM2B KDM2B GDF11 GDF11 SMAD4 SMAD4 FAM76B FAM76B HOXA11 HOXA11 ENSUAMP00000017947 ENSUAMP00000017947 ENSUAMP00000017946 ENSUAMP00000017946 HOXA7 HOXA7 HOXA6 HOXA6 HOXA5 HOXA5 HOXA3 HOXA3 HOXA2 HOXA2 ENSUAMP00000017830 ENSUAMP00000017830 TDGF1 TDGF1 MIB1 MIB1 ENSUAMP00000017468 ENSUAMP00000017468 ENSUAMP00000017162 ENSUAMP00000017162 TIFAB TIFAB NEUROG1 NEUROG1 TGFBR1 TGFBR1 MTHFSD MTHFSD FOXF1 FOXF1 HES6 HES6 HELT HELT NLE1 NLE1 ENSUAMP00000013328 ENSUAMP00000013328 ZBTB16 ZBTB16 WNT3A WNT3A ARC ARC ENSUAMP00000012266 ENSUAMP00000012266 CDON CDON COBL COBL ENSUAMP00000011871 ENSUAMP00000011871 ABI1 ABI1 TCAP TCAP TDRD1 TDRD1 GRSF1 GRSF1 HOXB1 HOXB1 HOXB2 HOXB2 HOXB3 HOXB3 OTX2 OTX2 HEY2 HEY2 NODAL NODAL HES1 HES1 ENSUAMP00000009330 ENSUAMP00000009330 ENSUAMP00000008823 ENSUAMP00000008823 CRKL CRKL FOXH1 FOXH1 BTG2 BTG2 ALX4 ALX4 MESP2 MESP2 PLD6 PLD6 HES7 HES7 ENSUAMP00000005111 ENSUAMP00000005111 ENSUAMP00000004964 ENSUAMP00000004964 ENSUAMP00000004918 ENSUAMP00000004918 TDRD15 TDRD15 SFRP1 SFRP1 RARG RARG CYP26C1 CYP26C1 MSGN1 MSGN1 LRP6 LRP6 DLL3 DLL3 NOG NOG HOXC13 HOXC13 HOXC11 HOXC11 HOXC10 HOXC10 HOXC9 HOXC9 AXIN2 AXIN2 HIPK2 HIPK2 ENSUAMP00000001190 ENSUAMP00000001190 TP53 TP53 LFNG LFNG MSX1 MSX1 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000025530 ENSUAMP00000025530 LRP5 LRP5 PAX1 PAX1 SEMA3C SEMA3C KDM6A KDM6A PCGF2 PCGF2 LDB1 LDB1 BMPR2 BMPR2 SOX17 SOX17 ENSUAMP00000036303 ENSUAMP00000036303 LHX1 LHX1 BMPR1A BMPR1A WNT3 WNT3 ENSUAMP00000035777 ENSUAMP00000035777 BPTF BPTF WNT1 WNT1 XRCC2 XRCC2 RING1 RING1 TASOR TASOR FRS2 FRS2 OSR1 OSR1 HOXC4 HOXC4 ENSUAMP00000034625 ENSUAMP00000034625 ENSUAMP00000034624 ENSUAMP00000034624 ENSUAMP00000034623 ENSUAMP00000034623 NOTCH1 NOTCH1 POGLUT1 POGLUT1 TAF10 TAF10 HOXD3 HOXD3 HOXD4 HOXD4 HOXD9 HOXD9 HOXD10 HOXD10 HOXD13 HOXD13 DDIT3 DDIT3 FOXB1 FOXB1 FEZF2 FEZF2 GLI3 GLI3 CDX1 CDX1 GBX2 GBX2 HES3 HES3 EP300 EP300 KAT2A KAT2A TBX6 TBX6 MEOX2 MEOX2 POFUT1 POFUT1 SCMH1 SCMH1 CDX2 CDX2 ZIC3 ZIC3 CER1 CER1 TBXT TBXT DLL1 DLL1 BMP4 BMP4 CELSR2 CELSR2 HOXB9 HOXB9 HOXB8 HOXB8 HOXB7 HOXB7 HOXB6 HOXB6 HOXB5 HOXB5 HOXB4 HOXB4 ENSUAMP00000028265 ENSUAMP00000028265 ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000027842 ENSUAMP00000027842 NRARP NRARP HEY1 HEY1 SMO SMO PCDH8 PCDH8 HIPK1 HIPK1 RNF2 RNF2 TULP3 TULP3 CDX4 CDX4 SMAD3 SMAD3 FAM76A FAM76A WNT8A WNT8A TSHZ1 TSHZ1 MEOX1 MEOX1 CRB2 CRB2 MYF5 MYF5 GPC3 GPC3 BMP2 BMP2 EMX2 EMX2 FEZF1 FEZF1 PGAP1 PGAP1 SRF SRF ENSUAMP00000000130 ENSUAMP00000000130 HEYL HEYL ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000397 ENSUAMP00000000397
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TDRKHTudor and KH domain containing. (581 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
CTNNBIP1Catenin beta interacting protein 1. (70 aa)
ENSUAMP00000019152Sema domain-containing protein. (489 aa)
ENSUAMP00000019144Plexin_cytopl domain-containing protein. (215 aa)
TDRD6Tudor domain containing 6. (2100 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2650 aa)
KDM2BLysine demethylase 2B. (1282 aa)
GDF11Growth differentiation factor 11. (409 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FAM76BFamily with sequence similarity 76 member B. (210 aa)
HOXA11Homeobox A11. (313 aa)
ENSUAMP00000017947Uncharacterized protein. (283 aa)
ENSUAMP00000017946Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA7Homeobox A7. (235 aa)
HOXA6Homeobox A6. (233 aa)
HOXA5Homeobox A5. (381 aa)
HOXA3Homeobox A3. (419 aa)
HOXA2Homeobox A2. (374 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (184 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1041 aa)
ENSUAMP00000017468Protein kinase domain-containing protein. (85 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
TIFABTIFA inhibitor. (187 aa)
NEUROG1Neurogenin 1. (251 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (318 aa)
FOXF1Forkhead box F1. (379 aa)
HES6Hes family bHLH transcription factor 6. (224 aa)
HELTHelt bHLH transcription factor. (242 aa)
NLE1Notchless homolog 1. (477 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
ZBTB16Zinc finger and BTB domain containing 16. (423 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
CDONCell adhesion associated, oncogene regulated. (1021 aa)
COBLCordon-bleu WH2 repeat protein. (1250 aa)
ENSUAMP00000011871PLAC domain-containing protein. (308 aa)
ABI1Abl interactor 1. (480 aa)
TCAPTitin-cap. (167 aa)
TDRD1Tudor domain containing 1. (1155 aa)
GRSF1G-rich RNA sequence binding factor 1. (279 aa)
HOXB1Homeobox B1. (301 aa)
HOXB2Homeobox B2. (346 aa)
HOXB3Homeobox B3. (254 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NODALNodal growth differentiation factor. (348 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
ENSUAMP00000009330BHLH domain-containing protein. (87 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FOXH1Forkhead box H1. (370 aa)
BTG2BTG anti-proliferation factor 2. (162 aa)
ALX4ALX homeobox 4. (408 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (376 aa)
PLD6Phospholipase D family member 6. (229 aa)
HES7Hes family bHLH transcription factor 7. (183 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
TDRD15Tudor domain containing 15. (1940 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
RARGRetinoic acid receptor gamma. (458 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
MSGN1Mesogenin 1. (187 aa)
LRP6LDL receptor related protein 6. (1431 aa)
DLL3Delta like canonical Notch ligand 3. (565 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXC13Homeobox C13. (317 aa)
HOXC11Homeobox C11. (304 aa)
HOXC10Homeobox C10. (342 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
AXIN2Axin 2. (843 aa)
HIPK2Homeodomain interacting protein kinase 2. (1200 aa)
ENSUAMP00000001190Homeobox domain-containing protein. (235 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (251 aa)
MSX1Msh homeobox 1. (303 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000025530P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (458 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
PAX1Paired box 1. (432 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
KDM6ALysine demethylase 6A. (1381 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
LDB1LIM domain binding 1. (411 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
SOX17SRY-box transcription factor 17. (406 aa)
ENSUAMP00000036303Orange domain-containing protein. (330 aa)
LHX1LIM homeobox 1. (406 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
BPTFBromodomain PHD finger transcription factor. (2478 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
RING1Ring finger protein 1. (406 aa)
TASORTranscription activation suppressor. (1518 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
HOXC4Homeobox C4. (264 aa)
ENSUAMP00000034625annotation not available (222 aa)
ENSUAMP00000034624Homeobox domain-containing protein. (222 aa)
ENSUAMP00000034623annotation not available (235 aa)
NOTCH1Notch receptor 1. (2547 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
HOXD3Homeobox D3. (432 aa)
HOXD4Homeobox D4. (187 aa)
HOXD9Homeobox D9. (341 aa)
HOXD10Homeobox D10. (410 aa)
HOXD13Homeobox D13. (333 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
FOXB1Forkhead box B1. (325 aa)
FEZF2FEZ family zinc finger 2. (443 aa)
GLI3GLI family zinc finger 3. (1413 aa)
CDX1Caudal type homeobox 1. (265 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
HES3Hes family bHLH transcription factor 3. (178 aa)
EP300E1A binding protein p300. (2399 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
TBX6T-box transcription factor 6. (436 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
POFUT1Protein O-fucosyltransferase 1. (391 aa)
SCMH1Scm polycomb group protein homolog 1. (582 aa)
CDX2Caudal type homeobox 2. (312 aa)
ZIC3Uncharacterized protein. (466 aa)
CER1Cerberus 1, DAN family BMP antagonist. (279 aa)
TBXTT-box transcription factor T. (435 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2928 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
HOXB8Homeobox B8. (243 aa)
HOXB7Homeobox B7. (217 aa)
HOXB6Homeobox B6. (224 aa)
HOXB5Homeobox B5. (269 aa)
HOXB4Homeobox B4. (240 aa)
ENSUAMP00000028265RING-type domain-containing protein. (357 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
PCDH8Protocadherin 8. (911 aa)
HIPK1Homeodomain interacting protein kinase 1. (822 aa)
RNF2Ring finger protein 2. (336 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (444 aa)
CDX4Caudal type homeobox 4. (284 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FAM76AFamily with sequence similarity 76 member A. (288 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
TSHZ1Teashirt zinc finger homeobox 1. (1074 aa)
MEOX1Mesenchyme homeobox 1. (254 aa)
CRB2Crumbs cell polarity complex component 2. (1280 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
FEZF1FEZ family zinc finger 1. (475 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa)
SRFSerum response factor. (507 aa)
ENSUAMP00000000130Bromo domain-containing protein. (70 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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