67 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX3	LIM homeobox 3. (403 aa)
	LHX1	LIM homeobox 1. (406 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	ENSUAMP00000035372	Uncharacterized protein. (332 aa)
	BMP1	Metalloendopeptidase. (568 aa)
	IFT52	Intraflagellar transport 52. (467 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (430 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	RFX4	Regulatory factor X4. (733 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	ENSUAMP00000031186	DZF domain-containing protein. (92 aa)
	ENSUAMP00000031091	Uncharacterized protein. (151 aa)
	ENSUAMP00000031029	Uncharacterized protein. (97 aa)
	EDN1	Endothelin 1. (202 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (279 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	LRP4	LDL receptor related protein 4. (1852 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	DISP1	SSD domain-containing protein. (1396 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (444 aa)
	TLL2	Metalloendopeptidase. (1021 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	INTU	Inturned planar cell polarity protein. (909 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	GLI1	GLI family zinc finger 1. (1105 aa)
	VAX2	Ventral anterior homeobox 2. (296 aa)
	LHX2	LIM homeobox 2. (392 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
	AXIN1	Axin 1. (867 aa)
	HOXA11	Homeobox A11. (313 aa)
	HOXA2	Homeobox A2. (374 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
	ENSUAMP00000017174	Uncharacterized protein. (171 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (476 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1268 aa)
	AIDA	Axin interactor, dorsalization associated. (276 aa)
	FOXA1	Forkhead box A1. (472 aa)
	ENSUAMP00000014514	RNF220 domain-containing protein. (104 aa)
	ENSUAMP00000014507	RING-type domain-containing protein. (245 aa)
	MDFI	MyoD family inhibitor. (246 aa)
	SP8	Sp8 transcription factor. (484 aa)
	ENSUAMP00000013631	DUF1619 domain-containing protein. (248 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	FOXN4	Forkhead box N4. (514 aa)
	HOXB2	Homeobox B2. (346 aa)
	ENSUAMP00000010247	Uncharacterized protein. (234 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (213 aa)
	ENSUAMP00000010093	SUFU_C domain-containing protein. (81 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (300 aa)
	GSC	Goosecoid homeobox. (256 aa)
	HHIP	Hedgehog interacting protein. (508 aa)
	PTCH1	Patched 1. (1453 aa)
	DBX1	Developing brain homeobox 1. (341 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (949 aa)
	SFRP1	Secreted frizzled related protein 1. (337 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (240 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ENSUAMP00000000397	Paired domain-containing protein. (216 aa)
	ENSUAMP00000000316	Homeobox domain-containing protein. (280 aa)
	ENSUAMP00000000118	DZF domain-containing protein. (843 aa)
	ENSUAMP00000000109	DZF domain-containing protein. (128 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1	ACVRL1	ENSUAMP00000003846	ENSUAMP00000017504	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.716
ACVR1	BMP4	ENSUAMP00000003846	ENSUAMP00000028868	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.989
ACVR1	BMPR1A	ENSUAMP00000003846	ENSUAMP00000036181	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.983
ACVR1	BMPR1B	ENSUAMP00000003846	ENSUAMP00000032869	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.975
ACVR1	SMAD6	ENSUAMP00000003846	ENSUAMP00000026564	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.692
ACVRL1	ACVR1	ENSUAMP00000017504	ENSUAMP00000003846	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.716
ACVRL1	BMP4	ENSUAMP00000017504	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.912
ACVRL1	BMPR1A	ENSUAMP00000017504	ENSUAMP00000036181	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
ACVRL1	BMPR1B	ENSUAMP00000017504	ENSUAMP00000032869	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.646
ACVRL1	SMAD6	ENSUAMP00000017504	ENSUAMP00000026564	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.661
ARL13B	ENSUAMP00000000316	ENSUAMP00000034057	ENSUAMP00000000316	ADP ribosylation factor like GTPase 13B.	Homeobox domain-containing protein.	0.517
ARL13B	ENSUAMP00000000397	ENSUAMP00000034057	ENSUAMP00000000397	ADP ribosylation factor like GTPase 13B.	Paired domain-containing protein.	0.517
ARL13B	ENSUAMP00000010093	ENSUAMP00000034057	ENSUAMP00000010093	ADP ribosylation factor like GTPase 13B.	SUFU_C domain-containing protein.	0.455
ARL13B	ENSUAMP00000013631	ENSUAMP00000034057	ENSUAMP00000013631	ADP ribosylation factor like GTPase 13B.	DUF1619 domain-containing protein.	0.536
ARL13B	ENSUAMP00000027842	ENSUAMP00000034057	ENSUAMP00000027842	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.576
ARL13B	ENSUAMP00000027843	ENSUAMP00000034057	ENSUAMP00000027843	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.576
ARL13B	ENSUAMP00000031029	ENSUAMP00000034057	ENSUAMP00000031029	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.563
ARL13B	GLI1	ENSUAMP00000034057	ENSUAMP00000024684	ADP ribosylation factor like GTPase 13B.	GLI family zinc finger 1.	0.532
ARL13B	GLI3	ENSUAMP00000034057	ENSUAMP00000032392	ADP ribosylation factor like GTPase 13B.	GLI family zinc finger 3.	0.576
ARL13B	IFT52	ENSUAMP00000034057	ENSUAMP00000034702	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.717