57 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK1IP1	PAK1 interacting protein 1. (421 aa)
	ENSUAMP00000034862	PSI domain-containing protein. (187 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (469 aa)
	HIPK4	Homeodomain interacting protein kinase 4. (616 aa)
	CD74	CD74 molecule. (279 aa)
	HIC1	HIC ZBTB transcriptional repressor 1. (713 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (414 aa)
	ENSUAMP00000032581	GST C-terminal domain-containing protein. (174 aa)
	HEXIM1	HEXIM P-TEFb complex subunit 1. (247 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	ING4	Inhibitor of growth protein. (247 aa)
	RFFL	Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (376 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (732 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1559 aa)
	ZNF385A	Zinc finger protein 385A. (386 aa)
	ENSUAMP00000027942	Link domain-containing protein. (477 aa)
	ENSUAMP00000026725	SEA domain-containing protein. (629 aa)
	C16orf72	Chromosome 16 open reading frame 72. (275 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	KMT5A	Lysine methyltransferase 5A. (327 aa)
	ENSUAMP00000024920	Uncharacterized protein. (194 aa)
	ENSUAMP00000023031	Uncharacterized protein. (118 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (504 aa)
	SIRT1	Sirtuin 1. (618 aa)
	ZNHIT1	Zinc finger HIT-type containing 1. (154 aa)
	ENSUAMP00000020461	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (824 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (151 aa)
	TRIM24	Tripartite motif containing 24. (1021 aa)
	SNAI2	Snail family transcriptional repressor 2. (230 aa)
	RNF34	Ring finger protein 34. (376 aa)
	RPF2	Ribosome production factor 2 homolog. (306 aa)
	ENSUAMP00000016331	Ubiquitin-like domain-containing protein. (153 aa)
	ENSUAMP00000012241	zf-RING_14 domain-containing protein. (109 aa)
	SMYD2	SET and MYND domain containing 2. (439 aa)
	RPL11	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (201 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	SOX4	Transcription factor SOX. (452 aa)
	BCL2L12	BCL2 like 12. (323 aa)
	ENSUAMP00000008823	TAN domain-containing protein. (111 aa)
	ENSUAMP00000007478	Uncharacterized protein. (285 aa)
	ENSUAMP00000006851	RBR-type E3 ubiquitin transferase. (137 aa)
	COPS3	COP9 signalosome subunit 3. (423 aa)
	SETD9	SET domain containing 9. (299 aa)
	ENSUAMP00000004964	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (445 aa)
	DYRK1A	Dual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
	ENSUAMP00000002126	zf-RING_14 domain-containing protein. (110 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	MSX1	Msh homeobox 1. (303 aa)
	ENSUAMP00000000381	Uncharacterized protein. (476 aa)
	DYRK3	Dual specificity tyrosine phosphorylation regulated kinase 3. (551 aa)
	PML	Promyelocytic leukemia. (877 aa)
	ENSUAMP00000033940	GST C-terminal domain-containing protein. (170 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD74	ENSUAMP00000024920	ENSUAMP00000032952	ENSUAMP00000024920	CD74 molecule.	Uncharacterized protein.	0.958
CD74	ENSUAMP00000027942	ENSUAMP00000032952	ENSUAMP00000027942	CD74 molecule.	Link domain-containing protein.	0.630
CD74	RPL11	ENSUAMP00000032952	ENSUAMP00000010901	CD74 molecule.	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.	0.958
DDX5	ENSUAMP00000020461	ENSUAMP00000030459	ENSUAMP00000020461	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.508
DDX5	RPF2	ENSUAMP00000030459	ENSUAMP00000017002	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Ribosome production factor 2 homolog.	0.624
DDX5	RRS1	ENSUAMP00000030459	ENSUAMP00000010336	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.562
DDX5	TP53	ENSUAMP00000030459	ENSUAMP00000000913	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.734
DYRK1A	TP53	ENSUAMP00000002238	ENSUAMP00000000913	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.567
DYRK3	ENSUAMP00000004964	ENSUAMP00000000315	ENSUAMP00000004964	Dual specificity tyrosine phosphorylation regulated kinase 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.507
DYRK3	ENSUAMP00000008823	ENSUAMP00000000315	ENSUAMP00000008823	Dual specificity tyrosine phosphorylation regulated kinase 3.	TAN domain-containing protein.	0.507
DYRK3	TP53	ENSUAMP00000000315	ENSUAMP00000000913	Dual specificity tyrosine phosphorylation regulated kinase 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.663
ENSUAMP00000000381	ENSUAMP00000004964	ENSUAMP00000000381	ENSUAMP00000004964	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.989
ENSUAMP00000000381	ENSUAMP00000008823	ENSUAMP00000000381	ENSUAMP00000008823	Uncharacterized protein.	TAN domain-containing protein.	0.989
ENSUAMP00000000381	ENSUAMP00000023031	ENSUAMP00000000381	ENSUAMP00000023031	Uncharacterized protein.	Uncharacterized protein.	0.437
ENSUAMP00000000381	TP53	ENSUAMP00000000381	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.986
ENSUAMP00000002126	ENSUAMP00000006851	ENSUAMP00000002126	ENSUAMP00000006851	zf-RING_14 domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.899
ENSUAMP00000002126	ENSUAMP00000012241	ENSUAMP00000002126	ENSUAMP00000012241	zf-RING_14 domain-containing protein.	zf-RING_14 domain-containing protein.	0.412
ENSUAMP00000002126	ENSUAMP00000016331	ENSUAMP00000002126	ENSUAMP00000016331	zf-RING_14 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.867
ENSUAMP00000004964	DYRK3	ENSUAMP00000004964	ENSUAMP00000000315	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.507
ENSUAMP00000004964	ENSUAMP00000000381	ENSUAMP00000004964	ENSUAMP00000000381	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.989