STRINGSTRING
APBB1IP APBB1IP GUCY1A1 GUCY1A1 ENSUAMP00000002341 ENSUAMP00000002341 ENSUAMP00000003355 ENSUAMP00000003355 ENSUAMP00000003358 ENSUAMP00000003358 ENSUAMP00000003512 ENSUAMP00000003512 ENSUAMP00000003880 ENSUAMP00000003880 PLCB2 PLCB2 ITPR3 ITPR3 ADCY9 ADCY9 ENSUAMP00000005976 ENSUAMP00000005976 PIK3CG PIK3CG ENSUAMP00000006289 ENSUAMP00000006289 ENSUAMP00000006694 ENSUAMP00000006694 ITGA2B ITGA2B COL3A1 COL3A1 ORAI1 ORAI1 ENSUAMP00000007690 ENSUAMP00000007690 PLCG2 PLCG2 MYL12B MYL12B MYL12A MYL12A GNAI3 GNAI3 ARHGEF1 ARHGEF1 ADCY2 ADCY2 RHOB RHOB ADCY3 ADCY3 PIK3CA PIK3CA ITGB1 ITGB1 PIK3R1 PIK3R1 AKT1 AKT1 PLCB1 PLCB1 RAP1B RAP1B ENSUAMP00000010836 ENSUAMP00000010836 MYLK3 MYLK3 AKT3 AKT3 ENSUAMP00000011731 ENSUAMP00000011731 P2RY12 P2RY12 PLA2G4A PLA2G4A ENSUAMP00000012405 ENSUAMP00000012405 RASGRP2 RASGRP2 ENSUAMP00000013407 ENSUAMP00000013407 MAPK1 MAPK1 CPN2 CPN2 LRRC15 LRRC15 PPP1CC PPP1CC GP1BB GP1BB F2RL3 F2RL3 ENSUAMP00000014629 ENSUAMP00000014629 ENSUAMP00000015637 ENSUAMP00000015637 ENSUAMP00000016192 ENSUAMP00000016192 TBXAS1 TBXAS1 MAPK12 MAPK12 MAPK11 MAPK11 ENSUAMP00000017435 ENSUAMP00000017435 FGG FGG FGA FGA FGB FGB ENSUAMP00000017692 ENSUAMP00000017692 P2RX1 P2RX1 RAP1A RAP1A ROCK1 ROCK1 PRKCI PRKCI PLCB3 PLCB3 FERMT3 FERMT3 PIK3CD PIK3CD PIK3R6 PIK3R6 F2R F2R PIK3R5 PIK3R5 GNAQ GNAQ STIM1 STIM1 ACTG1 ACTG1 PTGIR PTGIR TBXA2R TBXA2R ENSUAMP00000021877 ENSUAMP00000021877 ENSUAMP00000022131 ENSUAMP00000022131 ENSUAMP00000022172 ENSUAMP00000022172 RDH13 RDH13 ENSUAMP00000022491 ENSUAMP00000022491 P2RY1 P2RY1 ENSUAMP00000023048 ENSUAMP00000023048 ENSUAMP00000023102 ENSUAMP00000023102 PTGS1 PTGS1 GP9 GP9 ROCK2 ROCK2 PPP1CB PPP1CB PLA2G4F PLA2G4F PLA2G4D PLA2G4D VASP VASP ENSUAMP00000026030 ENSUAMP00000026030 COL1A2 COL1A2 BTK BTK FYN FYN ADCY5 ADCY5 ADCY1 ADCY1 ENSUAMP00000028100 ENSUAMP00000028100 GUCY1B1 GUCY1B1 GNAS GNAS MYLK MYLK ENSUAMP00000028672 ENSUAMP00000028672 JMJD7 JMJD7 PLCB4 PLCB4 PLA2G4E PLA2G4E VWF VWF ENSUAMP00000029679 ENSUAMP00000029679 SRC SRC SSPO SSPO MYLK2 MYLK2 ENSUAMP00000030750 ENSUAMP00000030750 MAPK3 MAPK3 RDH14 RDH14 SYK SYK ADCY4 ADCY4 SNAP23 SNAP23 RASGRP1 RASGRP1 MAPK14 MAPK14 MAPK13 MAPK13 ADCY7 ADCY7 ARHGEF12 ARHGEF12 ENSUAMP00000032618 ENSUAMP00000032618 NOS3 NOS3 PTK6 PTK6 SRMS SRMS PRKACB PRKACB TLNRD1 TLNRD1 PRKG2 PRKG2 FCER1G FCER1G ARHGAP35 ARHGAP35 ENSUAMP00000034022 ENSUAMP00000034022 F2 F2 ZNF408 ZNF408 ENSUAMP00000034830 ENSUAMP00000034830 ITGA2 ITGA2 ENSUAMP00000035331 ENSUAMP00000035331 TLN1 TLN1 ADCY6 ADCY6 ENSUAMP00000036253 ENSUAMP00000036253 VAMP8 VAMP8 LCP2 LCP2 GNAI2 GNAI2 ENSUAMP00000037462 ENSUAMP00000037462 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (596 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
ENSUAMP00000002341Uncharacterized protein. (957 aa)
ENSUAMP00000003355Uncharacterized protein. (76 aa)
ENSUAMP00000003358SER_THR_PHOSPHATASE domain-containing protein. (106 aa)
ENSUAMP00000003512LRRCT domain-containing protein. (390 aa)
ENSUAMP00000003880Uncharacterized protein. (91 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1166 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2656 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
ENSUAMP00000006289Uncharacterized protein. (158 aa)
ENSUAMP00000006694SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1032 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
ENSUAMP00000007690Uncharacterized protein. (259 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
MYL12BMyosin light chain 12B. (180 aa)
MYL12AMyosin light chain 12A. (172 aa)
GNAI3G protein subunit alpha i3. (295 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (975 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
RHOBRas homolog family member B. (172 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PLCB1Phosphoinositide phospholipase C. (658 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
ENSUAMP00000010836Uncharacterized protein. (951 aa)
MYLK3Myosin light chain kinase 3. (791 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
P2RY12Purinergic receptor P2Y12. (339 aa)
PLA2G4APhospholipase A2. (756 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
ENSUAMP00000013407Uncharacterized protein. (224 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
LRRC15Leucine rich repeat containing 15. (413 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (296 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (381 aa)
ENSUAMP00000014629Uncharacterized protein. (105 aa)
ENSUAMP00000015637I/LWEQ domain-containing protein. (735 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
TBXAS1Thromboxane A synthase 1. (441 aa)
MAPK12Mitogen-activated protein kinase 12. (373 aa)
MAPK11Mitogen-activated protein kinase. (357 aa)
ENSUAMP00000017435Uncharacterized protein. (459 aa)
FGGFibrinogen gamma chain. (437 aa)
FGAFibrinogen alpha chain. (1064 aa)
FGBFibrinogen beta chain. (272 aa)
ENSUAMP00000017692Uncharacterized protein. (704 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
FERMT3Fermitin family member 3. (663 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (869 aa)
GNAQG protein subunit alpha q. (352 aa)
STIM1Stromal interaction molecule 1. (818 aa)
ACTG1Actin gamma 1. (375 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (290 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ENSUAMP00000021877Uncharacterized protein. (80 aa)
ENSUAMP00000022131Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
ENSUAMP00000022172Uncharacterized protein. (157 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
ENSUAMP00000022491Ig-like domain-containing protein. (323 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
ENSUAMP00000023102Uncharacterized protein. (1102 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (618 aa)
GP9Glycoprotein IX platelet. (177 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PLA2G4FPhospholipase A2. (837 aa)
PLA2G4DPhospholipase A2. (776 aa)
VASPVasodilator stimulated phosphoprotein. (359 aa)
ENSUAMP00000026030Uncharacterized protein. (236 aa)
COL1A2Collagen type I alpha 2 chain. (1243 aa)
BTKTyrosine-protein kinase. (663 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY5Adenylate cyclase 5. (940 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSUAMP00000028100Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
GNASGNAS complex locus. (994 aa)
MYLKMyosin light chain kinase. (1485 aa)
ENSUAMP00000028672Phospholipase A2. (765 aa)
JMJD7Jumonji domain containing 7. (303 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1136 aa)
PLA2G4EPhospholipase A2. (822 aa)
VWFVon Willebrand factor. (2799 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
SRCTyrosine-protein kinase. (557 aa)
SSPOSCO-spondin. (5093 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
ENSUAMP00000030750Uncharacterized protein. (160 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RDH14Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
RASGRP1RAS guanyl releasing protein 1. (858 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1439 aa)
ENSUAMP00000032618Uncharacterized protein. (68 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
PTK6Tyrosine-protein kinase. (482 aa)
SRMSTyrosine-protein kinase. (492 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (361 aa)
TLNRD1Talin rod domain containing 1. (362 aa)
PRKG2cGMP-dependent protein kinase. (711 aa)
FCER1GFc fragment of IgE receptor Ig. (80 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
ENSUAMP00000034022Uncharacterized protein. (97 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
ZNF408Zinc finger protein 408. (719 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1121 aa)
ENSUAMP00000035331Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
TLN1Talin 1. (2550 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
LCP2Lymphocyte cytosolic protein 2. (511 aa)
GNAI2G protein subunit alpha i2. (436 aa)
ENSUAMP00000037462FERM domain-containing protein. (305 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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