STRINGSTRING
LOC101678178 LOC101678178 RARA RARA FOXP3 FOXP3 M3YRA0_MUSPF M3YRA0_MUSPF IL6 IL6 IL4R IL4R IL21R IL21R LAT LAT IKBKB IKBKB IL2RB IL2RB MAPK3 MAPK3 HSP90AB1 HSP90AB1 NFKBIE NFKBIE STAT1 STAT1 M3YLR8_MUSPF M3YLR8_MUSPF IL1R1 IL1R1 RXRA RXRA TGFBR2 TGFBR2 RELA RELA ZAP70 ZAP70 IL1B IL1B M3YH07_MUSPF M3YH07_MUSPF STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 IL4 IL4 IKBKG IKBKG M3YE13_MUSPF M3YE13_MUSPF M3YDZ3_MUSPF M3YDZ3_MUSPF M3YAY8_MUSPF M3YAY8_MUSPF TRBV25-1 TRBV25-1 M3YAV2_MUSPF M3YAV2_MUSPF M3YAT2_MUSPF M3YAT2_MUSPF IRF4 IRF4 IL6ST IL6ST TRAV18 TRAV18 M3Y7K5_MUSPF M3Y7K5_MUSPF IL6R IL6R M3Y7D3_MUSPF M3Y7D3_MUSPF M3Y7C9_MUSPF M3Y7C9_MUSPF M3Y779_MUSPF M3Y779_MUSPF NFATC3 NFATC3 TYK2 TYK2 TGFBR1 TGFBR1 HIF1A HIF1A M3Y4E6_MUSPF M3Y4E6_MUSPF JAK2 JAK2 M3XZW3_MUSPF M3XZW3_MUSPF CD3G CD3G CD3D CD3D CD3E CD3E MAPK13 MAPK13 MAPK14 MAPK14 RXRG RXRG PPP3CC PPP3CC RORC RORC PPP3CB PPP3CB IL1RAP IL1RAP MAPK1 MAPK1 IL27RA IL27RA HSP90AA1 HSP90AA1 MAPK12 MAPK12 MAPK10 MAPK10 RXRB RXRB MAPK11 MAPK11 M3XSM2_MUSPF M3XSM2_MUSPF HLA-DPA1 HLA-DPA1 HLA-DOA HLA-DOA HLA-DMA HLA-DMA M3XS76_MUSPF M3XS76_MUSPF M3XS58_MUSPF M3XS58_MUSPF STAT6 STAT6 IL23A IL23A RUNX1 RUNX1 IFNGR2 IFNGR2 SMAD2 SMAD2 IL23R IL23R RORA RORA JAK1 JAK1 MAPK9 MAPK9 SMAD3 SMAD3 JUN JUN M3Z2H3_MUSPF M3Z2H3_MUSPF NFKBIB NFKBIB PLCG1 PLCG1 TGFB1 TGFB1 NFATC2 NFATC2 IFNG IFNG IL22 IL22 IL2 IL2 IL21 IL21 CHUK CHUK CD4 CD4 NFATC1 NFATC1 MTOR MTOR GATA3 GATA3 PRKCQ PRKCQ IL2RA IL2RA NFKBIA NFKBIA JAK3 JAK3 IL12RB1 IL12RB1 CD247 CD247 TBX21 TBX21 LCK LCK IFNGR1 IFNGR1 PPP3CA PPP3CA NFKB1 NFKB1 FOS FOS MAPK8 MAPK8 IL17A IL17A IL17F IL17F SMAD4 SMAD4 M3YB13_MUSPF M3YB13_MUSPF M3YAZ8_MUSPF M3YAZ8_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101678178Ig-like domain-containing protein; Belongs to the MHC class II family. (196 aa)
RARARetinoic acid receptor, alpha. (462 aa)
FOXP3Forkhead box P3. (433 aa)
M3YRA0_MUSPFUncharacterized protein. (848 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
IL4RInterleukin 4 receptor. (805 aa)
IL21RInterleukin 21 receptor. (539 aa)
LATLinker for activation of T cells. (260 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL2RBInterleukin 2 receptor subunit beta. (554 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
NFKBIENFKB inhibitor epsilon. (394 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
M3YLR8_MUSPFRHD domain-containing protein. (249 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
RXRARetinoid X receptor alpha. (548 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (445 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
M3YH07_MUSPFIg-like domain-containing protein. (265 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
M3YE13_MUSPFIg-like domain-containing protein. (233 aa)
M3YDZ3_MUSPFMHC_II_alpha domain-containing protein. (236 aa)
M3YAY8_MUSPFIg-like domain-containing protein. (227 aa)
TRBV25-1T cell receptor beta variable 25-1. (125 aa)
M3YAV2_MUSPFIg-like domain-containing protein. (141 aa)
M3YAT2_MUSPFIg-like domain-containing protein. (186 aa)
IRF4Interferon regulatory factor 4. (451 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
TRAV18T cell receptor alpha variable 18. (159 aa)
M3Y7K5_MUSPFIg-like domain-containing protein. (163 aa)
IL6RInterleukin 6 receptor. (436 aa)
M3Y7D3_MUSPFDUF1968 domain-containing protein. (157 aa)
M3Y7C9_MUSPFIg-like domain-containing protein. (266 aa)
M3Y779_MUSPFIg-like domain-containing protein. (269 aa)
NFATC3Nuclear factor of activated T cells 3. (1037 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
M3Y4E6_MUSPFUncharacterized protein. (160 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
M3XZW3_MUSPFFibronectin type-III domain-containing protein. (374 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (180 aa)
CD3DCD3d molecule. (169 aa)
CD3ECD3 epsilon antigen. (186 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
RORCRAR related orphan receptor C. (492 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
IL1RAPInterleukin 1 receptor accessory protein. (568 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
IL27RAInterleukin 27 receptor subunit alpha. (654 aa)
HSP90AA1HATPase_c domain-containing protein. (679 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
RXRBRetinoid X receptor beta. (532 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
M3XSM2_MUSPFUncharacterized protein. (164 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (242 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
M3XS76_MUSPFIg-like domain-containing protein. (263 aa)
M3XS58_MUSPFIg-like domain-containing protein. (171 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
IL23AInterleukin 23 subunit alpha. (195 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
SMAD2Mothers against decapentaplegic homolog. (495 aa)
IL23RInterleukin 23 receptor. (632 aa)
RORARAR related orphan receptor A. (430 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
M3Z2H3_MUSPFIRF tryptophan pentad repeat domain-containing protein. (405 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
IL22Interleukin 22. (178 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CD4CD4. (462 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
GATA3GATA binding protein 3. (444 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IL2RAInterleukin 2 receptor subunit alpha. (267 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
JAK3Tyrosine-protein kinase. (1107 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (716 aa)
CD247CD247 molecule. (185 aa)
TBX21T-box transcription factor 21. (535 aa)
LCKTyrosine-protein kinase. (509 aa)
IFNGR1Interferon gamma receptor 1. (474 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
IL17AInterleukin 17A. (153 aa)
IL17FUncharacterized protein. (140 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
M3YB13_MUSPFIg-like domain-containing protein. (159 aa)
M3YAZ8_MUSPFIg-like domain-containing protein. (158 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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