STRINGSTRING
JAK1 JAK1 IL22RA1 IL22RA1 IFNG IFNG TYK2 TYK2 IL10RA IL10RA IL10 IL10 IL22 IL22 IFNAR2 IFNAR2 IFNGR1 IFNGR1 IFNAR1 IFNAR1 IFNGR2 IFNGR2 IL10RB IL10RB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1157 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (581 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL22Interleukin 22. (179 aa)
IFNAR2Uncharacterized protein. (519 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (562 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
IL10RBInterleukin 10 receptor subunit beta. (390 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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