STRINGSTRING
CARD9 CARD9 LOC101081297 LOC101081297 KARS1 KARS1 DEFB114 DEFB114 TLR3 TLR3 HAVCR2 HAVCR2 STAP1 STAP1 IL18 IL18 PRKD1 PRKD1 TNFSF14 TNFSF14 IL12B IL12B MAPK1 MAPK1 BMP6 BMP6 IL34 IL34 TLR4 TLR4 VAMP7 VAMP7 TRIM62 TRIM62 PTN PTN IL6 IL6 CD226 CD226 EMILIN2 EMILIN2 CXHXorf21 CXHXorf21 IFI35 IFI35 LRSAM1 LRSAM1 LOC101081599 LOC101081599 CCN4 CCN4 LOC101087936 LOC101087936 FEM1A FEM1A TOMM70 TOMM70 LGALS2 LGALS2 GPR4 GPR4 PSPC1 PSPC1 EMILIN1 EMILIN1 LY96 LY96 PARK7 PARK7 CCL24 CCL24 STK26 STK26 PTK2B PTK2B HSPB1 HSPB1 NLRP6 NLRP6 MOSPD2 MOSPD2 EREG EREG CXCR3 CXCR3 C3AR1 C3AR1 PUM2 PUM2 FABP4 FABP4 FGF16 FGF16 SCG2 SCG2 IL1RL1 IL1RL1 C2CD4D C2CD4D MSTN MSTN RIPK2 RIPK2 SCARF2 SCARF2 XRCC6 XRCC6 IL18RAP IL18RAP CCR2 CCR2 AKIRIN2 AKIRIN2 GPSM3 GPSM3 MMP8 MMP8 POLR3B POLR3B PDGFB PDGFB NTRK3 NTRK3 DEFB124 DEFB124 RIPK1 RIPK1 TXK TXK CD28 CD28 LAMP1 LAMP1 F7 F7 SYK SYK BMPR2 BMPR2 EDN2 EDN2 ANKRD17 ANKRD17 CXCL14 CXCL14 IKBKE IKBKE ZP3 ZP3 POLR3C POLR3C BRAF BRAF OXSR1 OXSR1 NUPR1 NUPR1 IL23A IL23A PRKCA PRKCA PDCD4 PDCD4 COCH COCH THBS1 THBS1 SIN3A SIN3A STK39 STK39 GHSR GHSR GHRL GHRL IL12A IL12A TNIP3 TNIP3 CMKLR1 CMKLR1 IL6ST IL6ST CSF1 CSF1 PRKD2 PRKD2 KDR KDR TMEM102 TMEM102 SETD4 SETD4 ABCC1 ABCC1 IL33 IL33 IFNG IFNG FFAR2 FFAR2 IL17F IL17F NOD2 NOD2 NMI NMI KLRAP1 KLRAP1 SH2D1A SH2D1A VEGFC VEGFC LGMN LGMN TLR10 TLR10 RBM14 RBM14 CCDC142 CCDC142 CD81 CD81 GAS6 GAS6 LAG3 LAG3 TNFRSF1A TNFRSF1A NTF3 NTF3 CCR1 CCR1 NEDD9 NEDD9 NFKBIA NFKBIA CYBA CYBA SERPINF2 SERPINF2 IL21 IL21 IRF3 IRF3 NLRC4 NLRC4 VEGFB VEGFB TNFSF11 TNFSF11 IL1B IL1B DEF6 DEF6 HEXIM1 HEXIM1 TGFB1 TGFB1 VAV1 VAV1 PLA2G5 PLA2G5 CD180 CD180 CXCL8 CXCL8 AGER AGER LTA LTA CDH13 CDH13 SLAMF1 SLAMF1 THBS4 THBS4 SWAP70 SWAP70 IDO1 IDO1 CSF1R CSF1R LOC102899310 LOC102899310 S100A9 S100A9 CCL21 CCL21 TREM2 TREM2 CX3CR1 CX3CR1 IL4 IL4 STAT5B STAT5B DHX58 DHX58 LRRK2 LRRK2 STING1 STING1 APP APP ZNFX1 ZNFX1 S100A8 S100A8 CD14 CD14 CCL5 CCL5 CRTAM CRTAM PARP9 PARP9 RIOK3 RIOK3 LOC101097531 LOC101097531 PVR PVR SNX4 SNX4 CCR6 CCR6 IL17RA IL17RA EIF4EBP3 EIF4EBP3 CCL19 CCL19 KLRK1 KLRK1 NPY NPY IFI16 IFI16 ENSFCAP00000060608 ENSFCAP00000060608 ENSFCAP00000060460 ENSFCAP00000060460 MET MET CXCL12 CXCL12 AIF1 AIF1 TNFRSF11A TNFRSF11A HABP2 HABP2 ZBP1 ZBP1 C1QBP C1QBP APOH APOH RNF31 RNF31 CD47 CD47 TNFSF4 TNFSF4 HMGB1 HMGB1 MMRN2 MMRN2 ETS1 ETS1 SMOC2 SMOC2 CD160 CD160 IL16 IL16 RAC2 RAC2 TRIM56 TRIM56 CREB3 CREB3 RASGRP1 RASGRP1 STAT5A STAT5A PQBP1 PQBP1 CXCL13 CXCL13 NKG7 NKG7 TBK1 TBK1 TAFA3 TAFA3 CASP6 CASP6 PRSS56 PRSS56 XRCC5 XRCC5 SH2D1B SH2D1B NFKBIZ NFKBIZ TRPV4 TRPV4 TYROBP TYROBP RIPOR2 RIPOR2 LSM14A LSM14A NAPEPLD NAPEPLD STX3 STX3 MCU MCU CADM1 CADM1 KLK7 KLK7 RAC3 RAC3 RARRES2 RARRES2 TTBK1 TTBK1 KLRD1 KLRD1 CXCL17 CXCL17 TNF TNF PYCARD PYCARD PUM1 PUM1 LDLR LDLR VEGFA VEGFA AKIRIN1 AKIRIN1 CLNK CLNK CNTF CNTF TIRAP TIRAP CEBPB CEBPB FGF18 FGF18 PLA2G3 PLA2G3 ACOD1 ACOD1 LOC101081130 LOC101081130 TRAF6 TRAF6 SCARF1 SCARF1 ARTN ARTN C2CD4B C2CD4B PDE2A PDE2A SFPQ SFPQ PGF PGF CLEC6A CLEC6A TRADD TRADD CGAS CGAS FADD FADD RNF185 RNF185 P2RX4 P2RX4 ANO6 ANO6 MED1 MED1 C2CD4C C2CD4C CXCL10 CXCL10 SASH1 SASH1 NCKAP1L NCKAP1L MEGF8 MEGF8 PLCG2 PLCG2 CCL26 CCL26 C5AR1 C5AR1 USP15 USP15 SLIT2 SLIT2 FKBP1B FKBP1B VAMP8 VAMP8 FLNA FLNA CCR7 CCR7 ADAM8 ADAM8 TLR9 TLR9 NOD1 NOD1 POLR3F POLR3F CCL27 CCL27 MATR3 MATR3 OSM OSM PTGER4 PTGER4 MAPK3 MAPK3 LOC100302540 LOC100302540 UBE2K UBE2K AP1G1 AP1G1 SLAMF6 SLAMF6 S100A14 S100A14 IL17A IL17A FGF10 FGF10 LY86 LY86
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CARD9Caspase recruitment domain family member 9. (732 aa)
LOC101081297Ig-like domain-containing protein; Belongs to the MHC class I family. (355 aa)
KARS1Lysine--tRNA ligase. (625 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
STAP1Signal transducing adaptor family member 1. (282 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
TNFSF14Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (242 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
IL34Interleukin 34. (331 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
TRIM62Tripartite motif containing 62. (475 aa)
PTNPleiotrophin. (179 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
CD226CD226 molecule. (332 aa)
EMILIN2Elastin microfibril interfacer 2. (969 aa)
CXHXorf21Chromosome X CXorf21 homolog. (333 aa)
IFI35Interferon induced protein 35. (287 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
LOC101081599SCY domain-containing protein. (158 aa)
CCN4Cellular communication network factor 4. (367 aa)
LOC101087936Uncharacterized protein. (373 aa)
FEM1AFem-1 homolog A. (655 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
LGALS2Galectin. (132 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PSPC1Paraspeckle component 1. (521 aa)
EMILIN1Elastin microfibril interfacer 1. (1025 aa)
LY96Lymphocyte antigen 96. (160 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
STK26Serine/threonine kinase 26. (416 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
MOSPD2Motile sperm domain containing 2. (518 aa)
EREGEpiregulin. (169 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
PUM2Pumilio RNA binding family member 2. (1063 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SCG2Secretogranin II. (680 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
C2CD4DC2 calcium dependent domain containing 4D. (342 aa)
MSTNMyostatin. (375 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
SCARF2Scavenger receptor class F member 2. (868 aa)
XRCC6X-ray repair cross complementing 6. (608 aa)
IL18RAPInterleukin 18 receptor accessory protein. (586 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
AKIRIN2Akirin 2. (203 aa)
GPSM3G protein signaling modulator 3. (160 aa)
MMP8Matrix metallopeptidase 8. (476 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TXKTyrosine-protein kinase. (551 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
LAMP1Lysosomal associated membrane protein 1. (422 aa)
F7Coagulation factor VII. (446 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa)
ANKRD17Ankyrin repeat domain 17. (2608 aa)
CXCL14C-X-C motif chemokine ligand 14. (110 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (435 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (557 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
PDCD4Programmed cell death 4. (469 aa)
COCHCochlin. (680 aa)
THBS1Thrombospondin 1. (1170 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
STK39Serine/threonine kinase 39. (543 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TNIP3TNFAIP3 interacting protein 3. (397 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
TMEM102Transmembrane protein 102. (510 aa)
SETD4SET domain containing 4. (453 aa)
ABCC1ATP binding cassette subfamily C member 1. (1486 aa)
IL33Interleukin 33. (268 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
IL17FInterleukin 17F. (157 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
NMIN-myc and STAT interactor. (309 aa)
KLRAP1Uncharacterized protein. (273 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
LGMNLegumain. (433 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (809 aa)
RBM14RNA binding motif protein 14. (669 aa)
CCDC142Coiled-coil domain containing 142. (785 aa)
CD81Tetraspanin. (236 aa)
GAS6Growth arrest specific 6. (674 aa)
LAG3Lymphocyte activating 3. (513 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
CCR1Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (565 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
IRF3Interferon regulatory factor 3. (420 aa)
NLRC4NLR family CARD domain containing 4. (1022 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (359 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
PLA2G5Phospholipase A(2). (158 aa)
CD180CD180 molecule. (661 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa)
CDH13Cadherin 13. (713 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
THBS4Thrombospondin 4. (964 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
LOC102899310Ig-like domain-containing protein. (320 aa)
S100A9Protein S100; Belongs to the S-100 family. (135 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
DHX58DExH-box helicase 58. (685 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
STING1Stimulator of interferon genes. (377 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
S100A8Protein S100; Belongs to the S-100 family. (124 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (828 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
LOC101097531Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
PVRPVR cell adhesion molecule. (380 aa)
SNX4Sorting nexin 4. (459 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (592 aa)
IL17RAInterleukin 17 receptor A. (862 aa)
EIF4EBP3ANK_REP_REGION domain-containing protein. (2635 aa)
CCL19C-C motif chemokine. (115 aa)
KLRK1Killer cell lectin like receptor K1. (215 aa)
NPYNeuropeptide Y; Belongs to the NPY family. (249 aa)
IFI16Uncharacterized protein. (684 aa)
ENSFCAP00000060608HIN-200 domain-containing protein. (171 aa)
ENSFCAP00000060460Ly49 domain-containing protein. (157 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
CXCL12Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
TNFRSF11ATNF receptor superfamily member 11a. (638 aa)
HABP2Hyaluronan binding protein 2. (562 aa)
ZBP1Z-DNA binding protein 1. (446 aa)
C1QBPComplement C1q binding protein. (314 aa)
APOHApolipoprotein H. (382 aa)
RNF31Uncharacterized protein. (1081 aa)
CD47CD47 molecule. (326 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
HMGB1Uncharacterized protein. (233 aa)
MMRN2Multimerin 2. (1005 aa)
ETS1ETS proto-oncogene 1, transcription factor. (503 aa)
SMOC2SPARC related modular calcium binding 2. (570 aa)
CD160CD160 molecule. (221 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1375 aa)
RAC2Rac family small GTPase 2. (234 aa)
TRIM56Tripartite motif containing 56. (770 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PQBP1Polyglutamine binding protein 1. (272 aa)
CXCL13C-X-C motif chemokine. (120 aa)
NKG7Natural killer cell granule protein 7. (189 aa)
TBK1TANK binding kinase 1. (729 aa)
TAFA3Uncharacterized protein. (284 aa)
CASP6Caspase 6; Belongs to the phospholipase A2 family. (431 aa)
PRSS56Serine protease 56. (665 aa)
XRCC5X-ray repair cross complementing 5. (747 aa)
SH2D1BSH2 domain-containing protein. (135 aa)
NFKBIZNFKB inhibitor zeta. (956 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (137 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1162 aa)
LSM14ALSM14A mRNA processing body assembly factor. (469 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (394 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (375 aa)
MCUMitochondrial calcium uniporter. (475 aa)
CADM1Cell adhesion molecule 1. (593 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (292 aa)
RAC3Rac family small GTPase 3. (205 aa)
RARRES2Retinoic acid receptor responder 2. (451 aa)
TTBK1Tau tubulin kinase 1. (1314 aa)
KLRD1Killer cell lectin like receptor D1. (186 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
PYCARDPYD and CARD domain containing. (195 aa)
PUM1Pumilio RNA binding family member 1. (1224 aa)
LDLRLow density lipoprotein receptor. (866 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
AKIRIN1Akirin 1. (192 aa)
CLNKCytokine dependent hematopoietic cell linker. (426 aa)
CNTFCiliary neurotrophic factor. (200 aa)
TIRAPTIR domain containing adaptor protein. (220 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
PLA2G3Phospholipase A2 group III. (522 aa)
ACOD1Aconitate decarboxylase 1. (482 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
ARTNArtemin. (220 aa)
C2CD4BUncharacterized protein. (404 aa)
PDE2APhosphodiesterase. (942 aa)
SFPQSplicing factor proline and glutamine rich. (701 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CLEC6AC-type lectin domain containing 6A. (212 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
CGASCyclic GMP-AMP synthase. (514 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
RNF185Ring finger protein 185. (192 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (389 aa)
ANO6Anoctamin. (932 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
C2CD4CC2 calcium dependent domain containing 4C. (480 aa)
CXCL10C-X-C motif chemokine. (98 aa)
SASH1SAM and SH3 domain containing 1. (1225 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
CCL26C-C motif chemokine. (94 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (790 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
FKBP1BPeptidylprolyl isomerase. (238 aa)
VAMP8Vesicle associated membrane protein 8. (99 aa)
FLNAFilamin A. (2808 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
ADAM8ADAM metallopeptidase domain 8. (872 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
CCL27C-C motif chemokine ligand 27. (113 aa)
MATR3Uncharacterized protein. (849 aa)
OSMOncostatin M. (238 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC100302540C-C motif chemokine. (93 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
AP1G1AP-1 complex subunit gamma. (829 aa)
SLAMF6Ig-like domain-containing protein. (390 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
IL17AInterleukin 17A. (155 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
LY86Lymphocyte antigen 86. (159 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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