(21 nodes) Regulation of regulatory T cell differentiation network (Felis catus)

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Your Input:
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
	BCL6	BCL6 transcription repressor. (745 aa)
	LAG3	Lymphocyte activating 3. (513 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	FANCD2	FA complementation group D2. (1450 aa)
	VSIR	V-set immunoregulatory receptor. (311 aa)
	IRF1	Interferon regulatory factor. (322 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	CD28	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	LOC101082108	Ig-like domain-containing protein. (386 aa)
	FOXO3	Forkhead box O3. (672 aa)
	SOX12	Transcription factor SOX. (314 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (268 aa)
	FOXP3	Forkhead box P3. (501 aa)
	FANCA	FA complementation group A. (1476 aa)
	SOCS1	Suppressor of cytokine signaling 1. (203 aa)
	LOC101081130	AIG1-type G domain-containing protein. (309 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (390 aa)
	DROSHA	Drosha ribonuclease III. (1374 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CTLA4	ENSFCAP00000006325	ENSFCAP00000041200	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.707
BCL6	FOXP3	ENSFCAP00000006325	ENSFCAP00000043740	BCL6 transcription repressor.	Forkhead box P3.	0.847
BCL6	IFNG	ENSFCAP00000006325	ENSFCAP00000008355	BCL6 transcription repressor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.610
CD28	CTLA4	ENSFCAP00000013242	ENSFCAP00000041200	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.	Cytotoxic T-lymphocyte associated protein 4.	0.608
CD28	FOXP3	ENSFCAP00000013242	ENSFCAP00000043740	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.	Forkhead box P3.	0.464
CD28	IFNG	ENSFCAP00000013242	ENSFCAP00000008355	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.465
CTLA4	BCL6	ENSFCAP00000041200	ENSFCAP00000006325	Cytotoxic T-lymphocyte associated protein 4.	BCL6 transcription repressor.	0.707
CTLA4	CD28	ENSFCAP00000041200	ENSFCAP00000013242	Cytotoxic T-lymphocyte associated protein 4.	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.	0.608
CTLA4	FOXP3	ENSFCAP00000041200	ENSFCAP00000043740	Cytotoxic T-lymphocyte associated protein 4.	Forkhead box P3.	0.863
CTLA4	IFNG	ENSFCAP00000041200	ENSFCAP00000008355	Cytotoxic T-lymphocyte associated protein 4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.812
CTLA4	LAG3	ENSFCAP00000041200	ENSFCAP00000006393	Cytotoxic T-lymphocyte associated protein 4.	Lymphocyte activating 3.	0.870
CTLA4	VSIR	ENSFCAP00000041200	ENSFCAP00000012102	Cytotoxic T-lymphocyte associated protein 4.	V-set immunoregulatory receptor.	0.417
FANCA	FANCD2	ENSFCAP00000045260	ENSFCAP00000010432	FA complementation group A.	FA complementation group D2.	0.997
FANCD2	FANCA	ENSFCAP00000010432	ENSFCAP00000045260	FA complementation group D2.	FA complementation group A.	0.997
FOXO3	KAT2A	ENSFCAP00000022859	ENSFCAP00000001984	Forkhead box O3.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.460
FOXP3	BCL6	ENSFCAP00000043740	ENSFCAP00000006325	Forkhead box P3.	BCL6 transcription repressor.	0.847
FOXP3	CD28	ENSFCAP00000043740	ENSFCAP00000013242	Forkhead box P3.	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.	0.464
FOXP3	CTLA4	ENSFCAP00000043740	ENSFCAP00000041200	Forkhead box P3.	Cytotoxic T-lymphocyte associated protein 4.	0.863
FOXP3	IFNG	ENSFCAP00000043740	ENSFCAP00000008355	Forkhead box P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.972
FOXP3	IL2RG	ENSFCAP00000043740	ENSFCAP00000049536	Forkhead box P3.	Fibronectin type-III domain-containing protein.	0.442