(22 nodes) Positive regulation of epidermal cell differentiation network (Felis catus)

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Your Input:
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	PTCH2	Patched 2. (1207 aa)
	PRKCH	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	NCOA3	Nuclear receptor coactivator. (1412 aa)
	KDF1	Keratinocyte differentiation factor 1. (397 aa)
	NOTCH1	Notch receptor 1. (2543 aa)
	SFRP4	Secreted frizzled related protein 4. (346 aa)
	VDR	Vitamin D receptor. (441 aa)
	TRIM16	Uncharacterized protein. (528 aa)
	ZBED2	Zinc finger BED-type containing 2. (218 aa)
	ATOH1	Atonal bHLH transcription factor 1. (356 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
	PTCH1	Patched 1. (1451 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (678 aa)
	ENSFCAP00000052961	LRAT domain-containing protein. (162 aa)
	ETV4	ETS variant 4. (488 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2135 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (252 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	NOTCH1	ENSFCAP00000040010	ENSFCAP00000020019	Atonal bHLH transcription factor 1.	Notch receptor 1.	0.535
ATOH1	PTCH1	ENSFCAP00000040010	ENSFCAP00000044951	Atonal bHLH transcription factor 1.	Patched 1.	0.468
BMP4	NOTCH1	ENSFCAP00000051185	ENSFCAP00000020019	Bone morphogenetic protein 4.	Notch receptor 1.	0.410
BMP4	PTCH1	ENSFCAP00000051185	ENSFCAP00000044951	Bone morphogenetic protein 4.	Patched 1.	0.526
CYP27B1	MED1	ENSFCAP00000013638	ENSFCAP00000044432	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.537
CYP27B1	VDR	ENSFCAP00000013638	ENSFCAP00000021493	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.855
CYP27C1	MED1	ENSFCAP00000012636	ENSFCAP00000044432	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.537
ETV4	NCOA3	ENSFCAP00000058647	ENSFCAP00000013944	ETS variant 4.	Nuclear receptor coactivator.	0.551
KDF1	SFN	ENSFCAP00000018056	ENSFCAP00000060640	Keratinocyte differentiation factor 1.	Stratifin; Belongs to the 14-3-3 family.	0.455
MED1	CYP27B1	ENSFCAP00000044432	ENSFCAP00000013638	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.537
MED1	CYP27C1	ENSFCAP00000044432	ENSFCAP00000012636	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.537
MED1	NCOA3	ENSFCAP00000044432	ENSFCAP00000013944	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.964
MED1	VDR	ENSFCAP00000044432	ENSFCAP00000021493	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D receptor.	0.859
NCOA3	ETV4	ENSFCAP00000013944	ENSFCAP00000058647	Nuclear receptor coactivator.	ETS variant 4.	0.551
NCOA3	MED1	ENSFCAP00000013944	ENSFCAP00000044432	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.964
NCOA3	VDR	ENSFCAP00000013944	ENSFCAP00000021493	Nuclear receptor coactivator.	Vitamin D receptor.	0.781
NOTCH1	ATOH1	ENSFCAP00000020019	ENSFCAP00000040010	Notch receptor 1.	Atonal bHLH transcription factor 1.	0.535
NOTCH1	BMP4	ENSFCAP00000020019	ENSFCAP00000051185	Notch receptor 1.	Bone morphogenetic protein 4.	0.410
NOTCH1	TRIM16	ENSFCAP00000020019	ENSFCAP00000021798	Notch receptor 1.	Uncharacterized protein.	0.440
PTCH1	ATOH1	ENSFCAP00000044951	ENSFCAP00000040010	Patched 1.	Atonal bHLH transcription factor 1.	0.468