STRINGSTRING
SCRIB SCRIB SOCS5 SOCS5 TBX21 TBX21 PLA2G2D PLA2G2D PTPN22 PTPN22 SHH SHH ANXA1 ANXA1 FOXP3 FOXP3 ENSFCAP00000060822 ENSFCAP00000060822 CD86 CD86 HMGB1 HMGB1 LOC101083890 LOC101083890 VSIG4 VSIG4 RIPOR2 RIPOR2 NDFIP1 NDFIP1 BMP4 BMP4 LAX1 LAX1 DLG1 DLG1 CEBPB CEBPB PRKAR1A PRKAR1A DUSP3 DUSP3 DLG2 DLG2 LOC101081130 LOC101081130 LOC101100430 LOC101100430 SOCS1 SOCS1 RC3H1 RC3H1 FGL1 FGL1 ILDR2 ILDR2 RC3H2 RC3H2 TIGIT TIGIT CBFB CBFB CD80 CD80 LGALS9 LGALS9 SOCS6 SOCS6 PDCD1LG2 PDCD1LG2 CD274 CD274 ITCH ITCH ZC3H12A ZC3H12A ZC3H8 ZC3H8 TSPAN32 TSPAN32 LAG3 LAG3 BCL6 BCL6 HFE HFE IL2RA IL2RA FOXJ1 FOXJ1 TNFAIP8L2 TNFAIP8L2 MAD1L1 MAD1L1 IFNB1 IFNB1 PTPN6 PTPN6 IDO1 IDO1 TMEM131L TMEM131L IL4 IL4 IL20RB IL20RB CLEC4G CLEC4G GLI3 GLI3 LRRC32 LRRC32 VSIR VSIR IRF1 IRF1 IL2 IL2 ARG2 ARG2 PAG1 PAG1 PTEN PTEN ZBTB7B ZBTB7B LRRC1 LRRC1 IHH IHH TWSG1 TWSG1 LOC101082108 LOC101082108 ADORA2A ADORA2A MARCHF7 MARCHF7 PRKAR1B PRKAR1B GPNMB GPNMB PAWR PAWR CBLB CBLB PELI1 PELI1 HAVCR2 HAVCR2 PRNP PRNP CASP3 CASP3 HLX HLX NRARP NRARP TNFRSF21 TNFRSF21 PLA2G2F PLA2G2F DLG5 DLG5 FGL2 FGL2 LOC101088701 LOC101088701 CTLA4 CTLA4 VTCN1 VTCN1 GLMN GLMN NCKAP1L NCKAP1L SMAD7 SMAD7 PTPN2 PTPN2 CRTAM CRTAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCRIBScribble planar cell polarity protein. (1637 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TBX21T-box transcription factor 21. (535 aa)
PLA2G2DPhospholipase A(2). (145 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
ANXA1Annexin. (407 aa)
FOXP3Forkhead box P3. (501 aa)
ENSFCAP00000060822Ig-like domain-containing protein. (252 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
HMGB1Uncharacterized protein. (233 aa)
LOC101083890Ig-like domain-containing protein. (285 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1162 aa)
NDFIP1Nedd4 family interacting protein 1. (224 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LAX1Lymphocyte transmembrane adaptor 1. (402 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
LOC101100430Galectin. (138 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
FGL1Fibrinogen like 1. (378 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (644 aa)
RC3H2Ring finger and CCCH-type domains 2. (1132 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (312 aa)
CBFBUncharacterized protein. (187 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
LGALS9Galectin. (356 aa)
SOCS6Suppressor of cytokine signaling 6. (497 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (302 aa)
CD274CD274 molecule. (297 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
ZC3H8Zinc finger CCCH-type containing 8. (311 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (289 aa)
LAG3Lymphocyte activating 3. (513 aa)
BCL6BCL6 transcription repressor. (745 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
FOXJ1Forkhead box J1. (417 aa)
TNFAIP8L2TNF alpha induced protein 8 like 2. (184 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (916 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
TMEM131LTransmembrane 131 like. (1609 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
IL20RBInterleukin 20 receptor subunit beta. (294 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
GLI3GLI family zinc finger 3. (1578 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
IRF1Interferon regulatory factor. (322 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
ARG2Arginase. (354 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (434 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ZBTB7BUncharacterized protein. (540 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (705 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
GPNMBGlycoprotein nmb. (568 aa)
PAWRPro-apoptotic WT1 regulator. (347 aa)
CBLBCbl proto-oncogene B. (1182 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
HLXH2.0 like homeobox. (569 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
TNFRSF21TNF receptor superfamily member 21. (651 aa)
PLA2G2FPhospholipase A(2). (211 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
FGL2Fibrinogen like 2. (440 aa)
LOC101088701Ig-like domain-containing protein. (370 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (268 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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