STRINGSTRING
GNAI2 GNAI2 GNAI1 GNAI1 GPSM1 GPSM1 NFKB1 NFKB1 CDK5R1 CDK5R1 ATF4 ATF4 SLC18A1 SLC18A1 SLC18A2 SLC18A2 MAOB MAOB CREB3L3 CREB3L3 GRIN2A GRIN2A RGS9 RGS9 LOC102900772 LOC102900772 ATF6B ATF6B GRIN3A GRIN3A CREB3L1 CREB3L1 GRIN2D GRIN2D GRM3 GRM3 PRKACA PRKACA JUN JUN CDK5 CDK5 FOSB FOSB ATF2 ATF2 GNAI3 GNAI3 PDYN PDYN GRM2 GRM2 CREB5 CREB5 GRIA2 GRIA2 DLG4 DLG4 TH TH PRKACB PRKACB GRIN2B GRIN2B MAOA MAOA RELA RELA DDC DDC DRD1 DRD1 BDNF BDNF GNAS GNAS CREB3 CREB3 GRIN1 GRIN1 PPP1R1B PPP1R1B GRIN2C GRIN2C CREB3L2 CREB3L2 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
GPSM1G protein signaling modulator 1. (704 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ATF4Activating transcription factor 4. (352 aa)
SLC18A1Solute carrier family 18 member A1. (519 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
MAOBAmine oxidase. (520 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
RGS9Regulator of G protein signaling 9. (668 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1116 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1338 aa)
GRM3Glutamate metabotropic receptor 3. (958 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PDYNProdynorphin. (255 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (797 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
MAOAAmine oxidase. (1178 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
DDCDopa decarboxylase. (480 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
GNASGNAS complex locus. (968 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1325 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.