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| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | RHOG | Ras homolog family member G. (191 aa) |
| | CD4 | CD4 molecule. (487 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | ELMO1 | Engulfment and cell motility 1. (742 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (846 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (550 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1022 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (342 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | WASF2 | WASP family member 2. (498 aa) |
| | FYB1 | FYN binding protein 1. (837 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (1069 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1889 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (744 aa) |
| | FN1 | Fibronectin 1. (2475 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | ACTR3 | Actin related protein 3; Belongs to the actin family. (418 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | WIPF1 | WAS/WASL interacting protein family member 1. (507 aa) |
| | WIPF2 | WAS/WASL interacting protein family member 2. (440 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | WAS | WASP actin nucleation promoting factor. (501 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (354 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1038 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | CDC42-2 | Uncharacterized protein. (191 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | CD8B | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (219 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (921 aa) |
| | WASL | WASP like actin nucleation promoting factor. (505 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1543 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | PKN1 | Protein kinase N1. (1064 aa) |
| | ARHGEF28 | Rho guanine nucleotide exchange factor 28. (1706 aa) |
| | ELMO2 | Engulfment and cell motility 2. (732 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | LIMK1 | LIM domain kinase 1. (763 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (548 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (534 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (741 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (815 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | BAIAP2 | BAI1 associated protein 2. (548 aa) |
| | GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (916 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (889 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | WIPF3 | WAS/WASL interacting protein family member 3. (487 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | ACTR3B | Uncharacterized protein; Belongs to the actin family. (522 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1085 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1391 aa) |
| | RAC2 | Rac family small GTPase 2. (234 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa) |
| | GIT2 | GIT ArfGAP 2. (786 aa) |
| | CD8A | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (248 aa) |
| | LOC111559549 | Ig-like domain-containing protein. (247 aa) |
| | ARF6 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (140 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
