STRINGSTRING
FCGR3A FCGR3A JAK1 JAK1 CYBB CYBB NFKBIB NFKBIB PTPN6 PTPN6 ITGAM ITGAM TGFB1 TGFB1 IL1B IL1B CYBA CYBA NFKBIA NFKBIA NFKB1 NFKB1 IL1A IL1A IFNG IFNG LOC101090518 LOC101090518 ITGA4 ITGA4 IRAK1 IRAK1 PRKCB PRKCB IL12A IL12A TAB2 TAB2 MAPK11 MAPK11 TAB1 TAB1 IL10 IL10 TGFB3 TGFB3 NCF4 NCF4 MAP3K7 MAP3K7 IRAK4 IRAK4 PTGS2 PTGS2 NCF2 NCF2 TLR2 TLR2 LOC101087936 LOC101087936 JUN JUN LOC101083959 LOC101083959 IFNGR1 IFNGR1 TLR4 TLR4 MAPK14 MAPK14 EEF1A1 EEF1A1 MAPK1 MAPK1 IL12B IL12B MARCKSL1 MARCKSL1 MAPK12 MAPK12 ITGB1 ITGB1 SLC26A3-2 SLC26A3-2 MAPK3 MAPK3 MYD88 MYD88 NOS2 NOS2 ITGB2 ITGB2 LOC101082653 LOC101082653 IFNGR2 IFNGR2 LOC101084962 LOC101084962 LOC101090265 LOC101090265 LOC111558970 LOC111558970 LOC101082906 LOC101082906 FOS FOS LOC101090771 LOC101090771 TRAF6 TRAF6 RELA RELA JAK2 JAK2 STAT1 STAT1 TNF TNF LOC111560444 LOC111560444 LOC101084108 LOC101084108 EEF1A2 EEF1A2 LOC109502152 LOC109502152 ELK1 ELK1 LOC111556169 LOC111556169 LOC111560443 LOC111560443 NCF1 NCF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FCGR3ACD16. (250 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1173 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
LOC101087936Uncharacterized protein. (373 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC101083959Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (460 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
MARCKSL1MARCKS like 1. (198 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
ITGB2Integrin beta. (867 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (474 aa)
LOC109502152Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (474 aa)
ELK1ETS transcription factor ELK1. (487 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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