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| | CCL2 | C-C motif chemokine. (99 aa) |
| | TXN2 | Thioredoxin 2. (163 aa) |
| | LOC101087880 | Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa) |
| | CTNNB1 | Catenin beta 1. (783 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MGST3 | Microsomal glutathione S-transferase 3. (190 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | LOC101096317 | Uncharacterized protein; Belongs to the GST superfamily. (223 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CALML6 | Calmodulin like 6. (180 aa) |
| | CALML4 | Calmodulin like 4. (196 aa) |
| | CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa) |
| | SLC29A1 | Heat shock protein 90 alpha family class B member 1. (740 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | VCAM1 | Vascular cell adhesion molecule 1. (748 aa) |
| | THBD | Thrombomodulin. (672 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (606 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (418 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (572 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (624 aa) |
| | NPPC | Natriuretic peptide C. (193 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa) |
| | MMP9 | Matrix metallopeptidase 9. (705 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | SQSTM1 | Sequestosome 1. (443 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | GSTM3 | Glutathione S-transferase. (226 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | LOC101101202 | Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | CALM2 | Calmodulin 2; Belongs to the calmodulin family. (149 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | LOC101086141 | Ubiquitin-like domain-containing protein. (208 aa) |
| | GSTO1 | Glutathione S-transferase omega 1. (241 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | NQO1 | NAD(P)H quinone dehydrogenase 1. (274 aa) |
| | M3WWP0_FELCA | Rad60-SLD domain-containing protein. (74 aa) |
| | PDP | Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa) |
| | LOC101083370 | Uncharacterized protein. (257 aa) |
| | ASS1 | Argininosuccinate synthase 1. (412 aa) |
| | NCF2 | Neutrophil cytosolic factor 2. (526 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2. (146 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | SDC4 | Syndecan 4. (201 aa) |
| | LOC101084793 | Uncharacterized protein. (222 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | LOC105259631 | Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | GPC1 | Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | LOC101097703 | EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | GSTM4 | Glutathione S-transferase mu 4; Belongs to the GST superfamily. (212 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | LOC101083114 | Uncharacterized protein; Belongs to the GST superfamily. (296 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | LOC111559123 | Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (784 aa) |
| | GSTT4 | Glutathione S-transferase theta 4; Belongs to the GST superfamily. (274 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1181 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | PLAT | Plasminogen activator; Belongs to the peptidase S1 family. (563 aa) |
| | GSTA4 | Glutathione S-transferase alpha 4. (222 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (333 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ENSFCAP00000037622 | Uncharacterized protein. (54 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC101082891 | Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa) |
| | MMP2 | Matrix metallopeptidase 2. (661 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | SELE | Selectin E. (638 aa) |
| | HSP90AA1 | Heat shock protein 90 alpha family class A member 1. (753 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | ENSFCAP00000043586 | Uncharacterized protein. (261 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | SUMO2 | Ubiquitin-like domain-containing protein. (108 aa) |
| | CDH5 | Uncharacterized protein. (402 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | SUMO1 | Ubiquitin-like domain-containing protein. (268 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | KLF2 | Kruppel like factor 2. (362 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | MAP2K5 | Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (764 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa) |
| | DUSP1 | Dual specificity phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (434 aa) |
| | PRKCZ | Protein kinase C zeta. (649 aa) |
| | RAC2 | Rac family small GTPase 2. (234 aa) |
| | SDC2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (210 aa) |
| | ACVR2B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa) |
| | GSTP1 | Uncharacterized protein; Belongs to the GST superfamily. (438 aa) |
| | HSP90B1 | Heat shock protein 90 beta family member 1. (809 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | NCF1 | Neutrophil cytosolic factor 1. (390 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | MGST1 | Microsomal glutathione S-transferase 1. (176 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
