STRINGSTRING
MTOR MTOR SHC3 SHC3 PDPK1 PDPK1 SHC1 SHC1 AKT2 AKT2 PRKACA PRKACA PIK3R1 PIK3R1 G6PC3 G6PC3 FOXO1 FOXO1 RPS6 RPS6 CBLB CBLB MAPK8 MAPK8 PHKG2 PHKG2 MAP2K1 MAP2K1 CALM2 CALM2 PYGL PYGL SLC2A4 SLC2A4 PDE3B PDE3B PTPN1 PTPN1 PIK3CB PIK3CB IKBKB IKBKB PPARGC1A PPARGC1A GCK GCK PPP1CB PPP1CB RHOQ RHOQ CRK CRK ACACA ACACA TSC1 TSC1 GYS1 GYS1 PYGB PYGB EIF4E2 EIF4E2 MAPK3 MAPK3 PTPRF PTPRF INPPL1 INPPL1 MAP2K2 MAP2K2 HK1 HK1 SOS2 SOS2 PIK3CA PIK3CA SOS1 SOS1 PRKAB1 PRKAB1 INPP5A INPP5A MAPK10 MAPK10 MKNK2 MKNK2 ELK1 ELK1 HKDC1 HKDC1 GRB2 GRB2 PRKCI PRKCI GSK3B GSK3B PHKG1 PHKG1 SOCS3 SOCS3 PPP1CC PPP1CC PRKAR1A PRKAR1A ARAF ARAF FLOT2 FLOT2 PRKAR2B PRKAR2B PIK3R2 PIK3R2 NRAS NRAS PRKAA2 PRKAA2 RPS6KB1 RPS6KB1 KRAS KRAS PRKAA1 PRKAA1 PRKCZ PRKCZ GYS2 GYS2 HK2 HK2 BAD BAD HRAS HRAS AKT1 AKT1 EIF4EBP1 EIF4EBP1 PIK3R3 PIK3R3 PRKAG3 PRKAG3 AKT3 AKT3 PRKAR2A PRKAR2A PRKAG1 PRKAG1 RAPGEF1 RAPGEF1 INSR INSR MAPK1 MAPK1 HK3 HK3 CBL CBL PPP1R3E PPP1R3E SOCS2 SOCS2 PCK1 PCK1 PHKB PHKB PRKAB2 PRKAB2 PHKA2 PHKA2 SREBF1 SREBF1 RPS6KB2 RPS6KB2 EIF4E1B EIF4E1B PRKAR1B PRKAR1B PHKA1 PHKA1 PPP1CA PPP1CA SHC2 SHC2 INS INS PCK2 PCK2 CALML6 CALML6 G6PC G6PC PPP1R3A PPP1R3A IRS4 IRS4 IRS1 IRS1 G6PC2 G6PC2 PYGM PYGM PRKACB PRKACB CRKL CRKL SOCS1 SOCS1 SH2B2 SH2B2 SOCS4 SOCS4 FASN FASN PPP1R3D PPP1R3D FBP2 FBP2 FBP1 FBP1 LOC109262226 LOC109262226 TSC2 TSC2 LOC109257442 LOC109257442 PPP1R3B PPP1R3B RHEB RHEB MAPK9 MAPK9 ACACB ACACB MKNK1 MKNK1 EIF4E EIF4E SHC4 SHC4 RPTOR RPTOR EXOC7 EXOC7 RAF1 RAF1 PPP1R3C PPP1R3C CALML5 CALML5 CALML3 CALML3 FLOT1 FLOT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR. (2550 aa)
SHC3SHC-transforming protein 3 isoform X1. (587 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PRKACACAMP-dependent protein kinase catalytic subunit alpha isoform X1. (351 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
G6PC3Glucose-6-phosphatase 3 isoform X1. (346 aa)
FOXO1Forkhead box protein O1. (655 aa)
RPS640S ribosomal protein S6 isoform X1. (249 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (984 aa)
MAPK8Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (427 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform. (406 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1. (393 aa)
CALM2Calmodulin. (149 aa)
PYGLGlycogen phosphorylase, liver form. (851 aa)
SLC2A4MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4. (461 aa)
PDE3BCGMP-inhibited 3',5'-cyclic phosphodiesterase B. (836 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1 isoform X1. (427 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1070 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (796 aa)
GCKGlucokinase. (480 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit. (327 aa)
RHOQRho-related GTP-binding protein RhoQ isoform X1. (205 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
ACACAAcetyl-CoA carboxylase / biotin carboxylase 1. (2383 aa)
TSC1Tuberous sclerosis 1. (1161 aa)
GYS1Glycogen [starch] synthase, muscle isoform X1. (737 aa)
PYGBGlycogen phosphorylase, brain form. (843 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1. (245 aa)
MAPK3Mitogen-activated protein kinase 1/3. (265 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (1906 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1264 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1. (400 aa)
HK1Hexokinase-1 isoform X1. (922 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1068 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PRKAB15'-AMP-activated protein kinase, regulatory beta subunit. (270 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1. (412 aa)
MAPK10Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (531 aa)
MKNK2LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2. (151 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
PRKCIProtein kinase C iota type isoform X1. (596 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1. (433 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform. (387 aa)
SOCS3Suppressor of cytokine signaling 3 isoform X1. (225 aa)
PPP1CCSerine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1. (337 aa)
PRKAR1ACAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
ARAFA-Raf proto-oncogene serine/threonine-protein kinase. (608 aa)
FLOT2Flotillin-2 isoform X1. (428 aa)
PRKAR2BCAMP-dependent protein kinase type II-beta regulatory subunit. (418 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta. (726 aa)
NRASGTPase NRas. (189 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1. (552 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1 isoform X1. (525 aa)
KRASGTPase KRas isoform X1. (189 aa)
PRKAA15'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1. (574 aa)
PRKCZProtein kinase C zeta type isoform X1. (583 aa)
GYS2Glycogen [starch] synthase, liver isoform X1. (702 aa)
HK2Hexokinase-2 isoform X1. (917 aa)
BADBcl2-associated agonist of cell death. (169 aa)
HRASGTPase HRas. (171 aa)
AKT1RAC-alpha serine/threonine-protein kinase isoform X1. (480 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1 isoform X1. (118 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta. (461 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X1. (485 aa)
AKT3RAC-gamma serine/threonine-protein kinase isoform X1. (479 aa)
PRKAR2ACAMP-dependent protein kinase type II-alpha regulatory subunit. (401 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1107 aa)
INSRInsulin receptor isoform X1. (1381 aa)
MAPK1Mitogen-activated protein kinase 1/3. (360 aa)
HK3Hexokinase-3 isoform X1. (924 aa)
CBLE3 ubiquitin-protein ligase CBL. (837 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3A/B/C/D/E. (279 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PHKBPhosphorylase b kinase regulatory subunit beta isoform X1. (1093 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
PHKA2Phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1. (1233 aa)
SREBF1Sterol regulatory element-binding transcription factor 1. (1174 aa)
RPS6KB2Ribosomal protein S6 kinase beta-2 isoform X1. (467 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B. (247 aa)
PRKAR1BCAMP-dependent protein kinase type I-beta regulatory subunit. (364 aa)
PHKA1Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1. (1238 aa)
PPP1CASerine/threonine-protein phosphatase PP1-alpha catalytic subunit. (330 aa)
SHC2SHC-transforming protein 2 isoform X1. (583 aa)
INSInsulin. (110 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (640 aa)
CALML6Calmodulin-like protein 6 isoform X1. (180 aa)
G6PCGlucose-6-phosphatase isoform X1. (357 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A/B/C/D/E. (1121 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
G6PC2Glucose-6-phosphatase 2. (355 aa)
PYGMGlycogen phosphorylase, muscle form. (842 aa)
PRKACBCAMP-dependent protein kinase catalytic subunit beta isoform X1. (397 aa)
CRKLProto-oncogene C-crk. (303 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
SH2B2SH2B adapter protein 2 isoform X1. (678 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
FASNFatty acid synthase, animal type. (2515 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D isoform X1. (297 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2. (339 aa)
FBP1Fructose-1,6-bisphosphatase 1. (338 aa)
LOC109262226Calmodulin-like. (143 aa)
TSC2Tuberous sclerosis 2. (1808 aa)
LOC109257442Calmodulin-alpha-like. (86 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit 3B isoform X1. (285 aa)
RHEBGTP-binding protein Rheb isoform X1. (184 aa)
MAPK9Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (424 aa)
ACACBAcetyl-CoA carboxylase / biotin carboxylase 2. (2447 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1. (330 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X1. (237 aa)
SHC4SHC-transforming protein 4. (630 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
EXOC7Exocyst complex component 7 isoform X1. (707 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3A/B/C/D/E. (317 aa)
CALML5Calmodulin-like. (149 aa)
CALML3Calmodulin-like protein 3. (149 aa)
FLOT1Flotillin-1 isoform X1. (427 aa)
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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