(21 nodes) Antifolate resistance network (Leptonychotes weddellii)

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proteins of unknown 3D structure

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Your Input:
	SLC46A1	Proton-coupled folate transporter isoform X1. (459 aa)
	LOC102737868	Canalicular multispecific organic anion transporter 1-like. (280 aa)
	LOC102736733	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family. (187 aa)
	FOLR2	Folate receptor beta isoform X1. (253 aa)
	FOLR1	Folate receptor alpha. (254 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
	ABCC3	Canalicular multispecific organic anion transporter 2. (1523 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC102748973	Multidrug resistance-associated protein 5-like. (836 aa)
	SLC19A1	Folate transporter 1. (507 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
	ATIC	Bifunctional purine biosynthesis protein PURH isoform X1. (594 aa)
	GGH	Folate gamma-glutamyl hydrolase. (319 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATIC	FPGS	A0A2U3XUE6	A0A2U3YKV0	Bifunctional purine biosynthesis protein PURH isoform X1.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.537
ATIC	GGH	A0A2U3XUE6	A0A2U3XS67	Bifunctional purine biosynthesis protein PURH isoform X1.	Folate gamma-glutamyl hydrolase.	0.514
ATIC	LOC102736733	A0A2U3XUE6	A0A2U3YWV2	Bifunctional purine biosynthesis protein PURH isoform X1.	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family.	0.948
ATIC	MTHFR	A0A2U3XUE6	A0A2U3XVU0	Bifunctional purine biosynthesis protein PURH isoform X1.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.798
ATIC	SHMT2	A0A2U3XUE6	A0A2U3Y8R8	Bifunctional purine biosynthesis protein PURH isoform X1.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.996
CHUK	IKBKB	A0A2U3YBY3	A0A2U3YJI5	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.999
CHUK	IKBKG	A0A2U3YBY3	A0A2U3Y6Q4	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B essential modulator isoform X2.	0.999
CHUK	IL1B	A0A2U3YBY3	A0A2U3YM52	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.584
CHUK	IL6	A0A2U3YBY3	A0A2U3YGL7	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Interleukin-6 isoform X1.	0.577
CHUK	NFKB1	A0A2U3YBY3	A0A2U3XMD9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Nuclear factor NF-kappa-B p105 subunit.	0.980
CHUK	TNF	A0A2U3YBY3	A0A2U3Y499	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.985
FOLR1	FOLR2	A0A2U3YPW0	A0A2U3YPX7	Folate receptor alpha.	Folate receptor beta isoform X1.	0.795
FOLR1	SLC46A1	A0A2U3YPW0	A0A2U3XJI2	Folate receptor alpha.	Proton-coupled folate transporter isoform X1.	0.477
FOLR2	FOLR1	A0A2U3YPX7	A0A2U3YPW0	Folate receptor beta isoform X1.	Folate receptor alpha.	0.795
FOLR2	SLC46A1	A0A2U3YPX7	A0A2U3XJI2	Folate receptor beta isoform X1.	Proton-coupled folate transporter isoform X1.	0.477
FPGS	ATIC	A0A2U3YKV0	A0A2U3XUE6	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Bifunctional purine biosynthesis protein PURH isoform X1.	0.537
FPGS	GGH	A0A2U3YKV0	A0A2U3XS67	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Folate gamma-glutamyl hydrolase.	0.939
FPGS	LOC102736733	A0A2U3YKV0	A0A2U3YWV2	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family.	0.950
FPGS	MTHFR	A0A2U3YKV0	A0A2U3XVU0	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.666
FPGS	SHMT2	A0A2U3YKV0	A0A2U3Y8R8	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.937