STRINGSTRING
GUCY1B3 GUCY1B3 PDGFC PDGFC LOC102725945 LOC102725945 GUCY1A3 GUCY1A3 REM1 REM1 KRAS KRAS GJA1 GJA1 HTR2C HTR2C NRAS NRAS CSDE1 CSDE1 LOC102742552 LOC102742552 ADCY6 ADCY6 MAP2K1 MAP2K1 GEM GEM TJP1 TJP1 GJD2 GJD2 MAPK7 MAPK7 RRAD RRAD DRD1 DRD1 LOC102726697 LOC102726697 LPAR1 LPAR1 SRC SRC HTR2B HTR2B LOC102732471 LOC102732471 TUBB TUBB TUBAL3 TUBAL3 LOC102744630 LOC102744630 LOC102726107 LOC102726107 LOC102725609 LOC102725609 GRM1 GRM1 LOC102731038 LOC102731038 PRKACA PRKACA TUBB3 TUBB3 LOC102743884 LOC102743884 LOC102730715 LOC102730715 LOC102748816 LOC102748816 CSNK1E CSNK1E PDGFRA PDGFRA MAP3K2 MAP3K2 PDGFB PDGFB PLCB3 PLCB3 LOC102746012 LOC102746012 LOC102739131 LOC102739131 LOC102733606 LOC102733606 LOC102738224 LOC102738224 GNA11 GNA11 ADCY9 ADCY9 LOC102739419 LOC102739419 ITPR3 ITPR3 MAPK1 MAPK1 LOC102731290 LOC102731290 TUBA4A TUBA4A TUBB1 TUBB1 LOC102742813 LOC102742813 TUBA8 TUBA8 ITPR1 ITPR1 PTRHD1 PTRHD1 PRKG1 PRKG1 CSNK1D CSNK1D RAF1 RAF1 MAP2K2 MAP2K2 ERAS ERAS ITPR2 ITPR2 PRKG2 PRKG2 GNAI2 GNAI2 TUBB4B TUBB4B PRKACB PRKACB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
KRASGTPase KRas isoform X2. (188 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1770 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LPAR1Lysophosphatidic acid receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
SRCTyrosine-protein kinase. (536 aa)
HTR2B5-hydroxytryptamine receptor 2B. (526 aa)
LOC102732471Tubulin alpha-1B chain-like. (134 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (398 aa)
LOC102744630D(2) dopamine receptor-like. (298 aa)
LOC102726107Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC102725609Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
GRM1Metabotropic glutamate receptor 1. (887 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (378 aa)
LOC102743884Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2. (359 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (540 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
LOC102739131D(2) dopamine receptor-like; Belongs to the G-protein coupled receptor 1 family. (198 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
LOC102738224LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (612 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LOC102739419Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
LOC102731290Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
CSNK1DCasein kinase I isoform delta isoform X2. (399 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ERASGTPase ERas. (233 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
PRKG2cGMP-dependent protein kinase 2. (553 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.