(32 nodes) Ribonuclease H-like superfamily network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZBED9	SCAN domain-containing protein 3. (1326 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (853 aa)
	REXO2	Oligoribonuclease, mitochondrial. (237 aa)
	AGO1	Protein argonaute-1 isoform X1; Belongs to the argonaute family. (854 aa)
	PRPF8	pre-mRNA-processing-splicing factor 8. (2335 aa)
	KRBA2	KRAB-A domain-containing protein 2. (491 aa)
	POLA1	DNA polymerase. (1467 aa)
	TEFM	Transcription elongation factor, mitochondrial isoform X2. (360 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)
	PIWIL1	Piwi-like protein 1; Belongs to the argonaute family. (861 aa)
	REXO5	Putative RNA exonuclease NEF-sp isoform X1. (774 aa)
	ERI2	ERI1 exoribonuclease 2 isoform X1. (680 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8 isoform X1. (292 aa)
	ESRP1	Epithelial splicing regulatory protein 1 isoform X2. (675 aa)
	PARN	poly(A)-specific ribonuclease PARN isoform X2. (627 aa)
	POLQ	DNA polymerase theta. (2722 aa)
	EXOSC10	Exosome component 10 isoform X2. (886 aa)
	GIN1	Gypsy retrotransposon integrase-like protein 1 isoform X2. (522 aa)
	REV3L	DNA polymerase zeta catalytic subunit isoform X1. (3122 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2. (344 aa)
	THAP12	52 kDa repressor of the inhibitor of the protein kinase. (732 aa)
	PIWIL2	Piwi-like protein 2 isoform X1; Belongs to the argonaute family. (964 aa)
	NYNRIN	Protein NYNRIN. (484 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	SRBD1	S1 RNA-binding domain-containing protein 1 isoform X4. (993 aa)
	PIWIL4	Piwi-like protein 4; Belongs to the argonaute family. (850 aa)
	EXD1	piRNA biogenesis protein EXD1. (512 aa)
	ZBED4	Zinc finger BED domain-containing protein 4. (1175 aa)
	ZMYM1	Zinc finger MYM-type protein 1 isoform X1. (1136 aa)
	TOE1	Target of EGR1 protein 1 isoform X1. (509 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1199 aa)
	ERI1	3'-5' exoribonuclease 1. (349 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO3	ENSTTRP00000014304	ENSTTRP00000014305	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.615
AGO1	AGO4	ENSTTRP00000014304	ENSTTRP00000014300	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.975
AGO3	AGO1	ENSTTRP00000014305	ENSTTRP00000014304	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.615
AGO3	AGO4	ENSTTRP00000014305	ENSTTRP00000014300	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.565
AGO4	AGO1	ENSTTRP00000014300	ENSTTRP00000014304	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.975
AGO4	AGO3	ENSTTRP00000014300	ENSTTRP00000014305	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.565
CNOT7	CNOT8	ENSTTRP00000011922	ENSTTRP00000015110	CCR4-NOT transcription complex subunit 7.	CCR4-NOT transcription complex subunit 8 isoform X1.	0.965
CNOT7	PARN	ENSTTRP00000011922	ENSTTRP00000002666	CCR4-NOT transcription complex subunit 7.	poly(A)-specific ribonuclease PARN isoform X2.	0.538
CNOT7	POLA1	ENSTTRP00000011922	ENSTTRP00000004988	CCR4-NOT transcription complex subunit 7.	DNA polymerase.	0.528
CNOT8	CNOT7	ENSTTRP00000015110	ENSTTRP00000011922	CCR4-NOT transcription complex subunit 8 isoform X1.	CCR4-NOT transcription complex subunit 7.	0.965
CNOT8	PARN	ENSTTRP00000015110	ENSTTRP00000002666	CCR4-NOT transcription complex subunit 8 isoform X1.	poly(A)-specific ribonuclease PARN isoform X2.	0.517
CNOT8	POLA1	ENSTTRP00000015110	ENSTTRP00000004988	CCR4-NOT transcription complex subunit 8 isoform X1.	DNA polymerase.	0.528
ERI1	ERI2	ENSTTRP00000006682	ENSTTRP00000015581	3'-5' exoribonuclease 1.	ERI1 exoribonuclease 2 isoform X1.	0.414
ERI1	EXOSC10	ENSTTRP00000006682	ENSTTRP00000001240	3'-5' exoribonuclease 1.	Exosome component 10 isoform X2.	0.402
ERI2	ERI1	ENSTTRP00000015581	ENSTTRP00000006682	ERI1 exoribonuclease 2 isoform X1.	3'-5' exoribonuclease 1.	0.414
EXD1	PIWIL2	ENSTTRP00000009307	ENSTTRP00000012093	piRNA biogenesis protein EXD1.	Piwi-like protein 2 isoform X1; Belongs to the argonaute family.	0.726
EXOSC10	ERI1	ENSTTRP00000001240	ENSTTRP00000006682	Exosome component 10 isoform X2.	3'-5' exoribonuclease 1.	0.402
EXOSC10	ISG20L2	ENSTTRP00000001240	ENSTTRP00000013756	Exosome component 10 isoform X2.	Interferon-stimulated 20 kDa exonuclease-like 2.	0.557
EXOSC10	PAN2	ENSTTRP00000001240	ENSTTRP00000006766	Exosome component 10 isoform X2.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.557
EXOSC10	REXO2	ENSTTRP00000001240	ENSTTRP00000014149	Exosome component 10 isoform X2.	Oligoribonuclease, mitochondrial.	0.532