STRINGSTRING
NFKB1 NFKB1 NPY NPY MAPK9 MAPK9 PPARA PPARA MAPK10 MAPK10 LEP LEP MTOR MTOR G6PC2 G6PC2 ADIPOR1 ADIPOR1 ADIPOR2 ADIPOR2 PRKCQ PRKCQ RXRA RXRA RXRG RXRG ACSL6 ACSL6 JAK2 JAK2 LOC102973323 LOC102973323 AKT1 AKT1 NFKBIE NFKBIE AKT2 AKT2 TRAF2 TRAF2 MAPK8 MAPK8 ACSL3 ACSL3 PRKAG1 PRKAG1 NFKBIA NFKBIA ACSL1 ACSL1 NFKBIB NFKBIB STAT3 STAT3 PRKAG2 PRKAG2 ADIPOQ ADIPOQ CPT1C CPT1C PPARGC1A PPARGC1A RXRB RXRB G6PC G6PC IRS1 IRS1 AGRP AGRP PTPN11 PTPN11 TNF TNF SLC2A4 SLC2A4 TNFRSF1A TNFRSF1A IKBKG IKBKG LOC102992378 LOC102992378 PRKAB2 PRKAB2 ACSL5 ACSL5 ACSBG2 ACSBG2 TNFRSF1B TNFRSF1B G6PC3 G6PC3 CHUK CHUK ACACB ACACB PCK1 PCK1 PRKAA1 PRKAA1 IKBKB IKBKB PRKAB1 PRKAB1 IRS2 IRS2 RELA RELA SLC2A1 SLC2A1 ACSBG1 ACSBG1 STK11 STK11 PCK2 PCK2 CAMKK2 CAMKK2 POMC POMC CPT1B CPT1B LOC102982336 LOC102982336 SOCS3 SOCS3 PRKAG3 PRKAG3 LEPR LEPR PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
NPYPro-neuropeptide Y isoform X2. (97 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (506 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RXRARetinoic acid receptor RXR-alpha. (457 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (340 aa)
ACSL6long-chain-fatty-acid--CoA ligase 6 isoform X8. (722 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC102973323Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NFKBIENF-kappa-B inhibitor epsilon. (362 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3 isoform X1. (720 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
ACSL1long-chain-fatty-acid--CoA ligase 1. (698 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X3. (413 aa)
ADIPOQAdiponectin. (242 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform; Belongs to the carnitine/choline acetyltransferase family. (801 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4. (796 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (540 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
IRS1Insulin receptor substrate 1. (1245 aa)
AGRPAgouti-related protein. (134 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A isoform X1. (442 aa)
IKBKGNF-kappa-B essential modulator. (361 aa)
LOC102992378Carnitine O-palmitoyltransferase 1, liver isoform isoform X2; Belongs to the carnitine/choline acetyltransferase family. (339 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
ACSL5long-chain-fatty-acid--CoA ligase 5 isoform X2. (682 aa)
ACSBG2long-chain-fatty-acid--CoA ligase ACSBG2. (672 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B isoform X1. (454 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (1777 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X1. (270 aa)
IRS2Insulin receptor substrate 2 isoform X1. (1370 aa)
RELATranscription factor p65 isoform X3. (551 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (534 aa)
ACSBG1long-chain-fatty-acid--CoA ligase ACSBG1. (724 aa)
STK11Serine/threonine-protein kinase STK11 isoform X4; Belongs to the protein kinase superfamily. (437 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (646 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X2. (580 aa)
POMCPro-opiomelanocortin. (260 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
LOC102982336LOW QUALITY PROTEIN: insulin receptor substrate 1-like. (540 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X4. (486 aa)
LEPRLeptin receptor. (1165 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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