| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | MLH1 | ENSLAFP00000006871 | ENSLAFP00000021811 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | MutL homolog 1. | 0.893 |
| ATM | SPO11 | ENSLAFP00000006871 | ENSLAFP00000012831 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | SPO11 initiator of meiotic double stranded breaks. | 0.746 |
| ATM | TERF1 | ENSLAFP00000006871 | ENSLAFP00000003592 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.633 |
| ATM | TERF2 | ENSLAFP00000006871 | ENSLAFP00000004051 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | TERF2_RBM domain-containing protein. | 0.615 |
| CCDC155 | MAJIN | ENSLAFP00000018122 | ENSLAFP00000006770 | Coiled-coil domain containing 155. | Membrane anchored junction protein. | 0.515 |
| CCDC155 | SUN1 | ENSLAFP00000018122 | ENSLAFP00000013423 | Coiled-coil domain containing 155. | Sad1 and UNC84 domain containing 1. | 0.957 |
| CCDC155 | TERB1 | ENSLAFP00000018122 | ENSLAFP00000007601 | Coiled-coil domain containing 155. | Telomere repeat binding bouquet formation protein 1. | 0.554 |
| CCDC155 | TERB2 | ENSLAFP00000018122 | ENSLAFP00000004956 | Coiled-coil domain containing 155. | Telomere repeat binding bouquet formation protein 2. | 0.519 |
| MAJIN | CCDC155 | ENSLAFP00000006770 | ENSLAFP00000018122 | Membrane anchored junction protein. | Coiled-coil domain containing 155. | 0.515 |
| MAJIN | SUN1 | ENSLAFP00000006770 | ENSLAFP00000013423 | Membrane anchored junction protein. | Sad1 and UNC84 domain containing 1. | 0.525 |
| MAJIN | TERB1 | ENSLAFP00000006770 | ENSLAFP00000007601 | Membrane anchored junction protein. | Telomere repeat binding bouquet formation protein 1. | 0.890 |
| MAJIN | TERB2 | ENSLAFP00000006770 | ENSLAFP00000004956 | Membrane anchored junction protein. | Telomere repeat binding bouquet formation protein 2. | 0.978 |
| MAJIN | TERF1 | ENSLAFP00000006770 | ENSLAFP00000003592 | Membrane anchored junction protein. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.412 |
| MAJIN | TERF2 | ENSLAFP00000006770 | ENSLAFP00000004051 | Membrane anchored junction protein. | TERF2_RBM domain-containing protein. | 0.601 |
| MLH1 | ATM | ENSLAFP00000021811 | ENSLAFP00000006871 | MutL homolog 1. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.893 |
| MLH1 | SPO11 | ENSLAFP00000021811 | ENSLAFP00000012831 | MutL homolog 1. | SPO11 initiator of meiotic double stranded breaks. | 0.723 |
| SPO11 | ATM | ENSLAFP00000012831 | ENSLAFP00000006871 | SPO11 initiator of meiotic double stranded breaks. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.746 |
| SPO11 | MLH1 | ENSLAFP00000012831 | ENSLAFP00000021811 | SPO11 initiator of meiotic double stranded breaks. | MutL homolog 1. | 0.723 |
| SUN1 | CCDC155 | ENSLAFP00000013423 | ENSLAFP00000018122 | Sad1 and UNC84 domain containing 1. | Coiled-coil domain containing 155. | 0.957 |
| SUN1 | MAJIN | ENSLAFP00000013423 | ENSLAFP00000006770 | Sad1 and UNC84 domain containing 1. | Membrane anchored junction protein. | 0.525 |