(40 nodes) Intrinsic component of mitochondrial membrane network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	COQ2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (361 aa)
	IMMT	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (757 aa)
	CHCHD3	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (218 aa)
	MCUR1	Mitochondrial calcium uniporter regulator 1. (210 aa)
	GDAP1	Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
	SCO1	SCO cytochrome c oxidase assembly protein 1. (277 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (630 aa)
	COX18	Cytochrome c oxidase assembly factor COX18. (325 aa)
	MFN1	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (740 aa)
	GHITM	Growth hormone inducible transmembrane protein; Belongs to the BI1 family. (345 aa)
	CHCHD6	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (146 aa)
	OMA1	OMA1 zinc metallopeptidase. (525 aa)
	BNIP3	BCL2 interacting protein 3. (179 aa)
	TMEM70	Uncharacterized protein. (185 aa)
	COX11	Cytochrome c oxidase copper chaperone COX11. (275 aa)
	UQCC3	Ubiquinol-cytochrome c reductase complex assembly factor 3. (90 aa)
	COA3	Cytochrome c oxidase assembly factor 3. (106 aa)
	PINK1	PTEN induced kinase 1. (582 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (621 aa)
	FUNDC1	FUN14 domain containing 1. (155 aa)
	GDAP1L1	Ganglioside induced differentiation associated protein 1 like 1. (370 aa)
	MICOS10	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (74 aa)
	SPIRE1	Spire type actin nucleation factor 1. (642 aa)
	SYNJ2BP-COX16	SYNJ2BP-COX16 readthrough. (181 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (798 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (704 aa)
	ADCK2	AarF domain containing kinase 2. (576 aa)
	LOC100660900	AAA domain-containing protein. (787 aa)
	PPOX	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (477 aa)
	OXA1L	OXA1L mitochondrial inner membrane protein. (437 aa)
	ABCB10	ATP binding cassette subfamily B member 10. (601 aa)
	DNAJC11	DnaJ heat shock protein family (Hsp40) member C11. (559 aa)
	APOOL	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (269 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (777 aa)
	RHOT2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (624 aa)
	TMEM11	Transmembrane protein 11. (192 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (575 aa)
	APOO	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (200 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	LOC100660900	ENSLAFP00000013918	ENSLAFP00000017395	AFG3 like matrix AAA peptidase subunit 2.	AAA domain-containing protein.	0.901
AFG3L2	OMA1	ENSLAFP00000013918	ENSLAFP00000008201	AFG3 like matrix AAA peptidase subunit 2.	OMA1 zinc metallopeptidase.	0.554
AFG3L2	SPG7	ENSLAFP00000013918	ENSLAFP00000020667	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.818
APOO	APOOL	ENSLAFP00000025970	ENSLAFP00000020664	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.885
APOO	CHCHD3	ENSLAFP00000025970	ENSLAFP00000002607	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.896
APOO	CHCHD6	ENSLAFP00000025970	ENSLAFP00000008164	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.903
APOO	DNAJC11	ENSLAFP00000025970	ENSLAFP00000020551	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	DnaJ heat shock protein family (Hsp40) member C11.	0.710
APOO	IMMT	ENSLAFP00000025970	ENSLAFP00000001108	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.909
APOO	MICOS10	ENSLAFP00000025970	ENSLAFP00000013597	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.825
APOOL	APOO	ENSLAFP00000020664	ENSLAFP00000025970	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.885
APOOL	CHCHD3	ENSLAFP00000020664	ENSLAFP00000002607	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.919
APOOL	CHCHD6	ENSLAFP00000020664	ENSLAFP00000008164	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.913
APOOL	DNAJC11	ENSLAFP00000020664	ENSLAFP00000020551	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	DnaJ heat shock protein family (Hsp40) member C11.	0.725
APOOL	IMMT	ENSLAFP00000020664	ENSLAFP00000001108	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.903
APOOL	MICOS10	ENSLAFP00000020664	ENSLAFP00000013597	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.857
APOOL	TMEM11	ENSLAFP00000020664	ENSLAFP00000025415	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Transmembrane protein 11.	0.577
BNIP3	FUNDC1	ENSLAFP00000008894	ENSLAFP00000012756	BCL2 interacting protein 3.	FUN14 domain containing 1.	0.639
BNIP3	MFN1	ENSLAFP00000008894	ENSLAFP00000007438	BCL2 interacting protein 3.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.476
BNIP3	PINK1	ENSLAFP00000008894	ENSLAFP00000011359	BCL2 interacting protein 3.	PTEN induced kinase 1.	0.565
BNIP3	TMEM11	ENSLAFP00000008894	ENSLAFP00000025415	BCL2 interacting protein 3.	Transmembrane protein 11.	0.465

page 1 of 8

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About