STRINGSTRING
SMG1 SMG1 RHOB RHOB BCL2 BCL2 CCL2 CCL2 DHX15 DHX15 MDM2 MDM2 TP53 TP53 RHOA RHOA RAD52 RAD52 SRSF3 SRSF3 IGFBP7 IGFBP7 KLF4 KLF4 KLF5 KLF5 EGR1 EGR1 LIG4 LIG4 STAT3 STAT3 CCNG1 CCNG1 STUB1 STUB1 SRSF7 SRSF7 SRSF1 SRSF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3662 aa)
RHOBRas homolog family member B. (196 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
CCL2C-C motif chemokine. (133 aa)
DHX15DEAH-box helicase 15. (792 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (492 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
RHOARas homolog family member A. (193 aa)
RAD52RAD52 homolog, DNA repair protein. (411 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
IGFBP7Insulin like growth factor binding protein 7. (283 aa)
KLF4Kruppel like factor 4. (517 aa)
KLF5Kruppel like factor 5. (446 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (548 aa)
LIG4DNA ligase. (913 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (298 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SRSF7Serine and arginine rich splicing factor 7. (266 aa)
SRSF1Uncharacterized protein. (248 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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