STRINGSTRING
RAP1A RAP1A MYL9 MYL9 ERBB2 ERBB2 BCL2 BCL2 ITGA4 ITGA4 ACTN1 ACTN1 PIK3R2 PIK3R2 LAMB1 LAMB1 PRKCB PRKCB ITGB8 ITGB8 ACTB ACTB PIK3CD PIK3CD ITGB5 ITGB5 ITGB6 ITGB6 MYLK2 MYLK2 VWF VWF TLN1 TLN1 ITGA3 ITGA3 THBS1 THBS1 AKT2 AKT2 BIRC2 BIRC2 PIK3CA PIK3CA LAMA2 LAMA2 DOCK1 DOCK1 RELN RELN LAMA4 LAMA4 COL4A4 COL4A4 PDGFD PDGFD ITGA2B ITGA2B MYL12B MYL12B ITGAV ITGAV VEGFD VEGFD ITGA6 ITGA6 LAMB3 LAMB3 PAK4 PAK4 PTEN PTEN PPP1CB PPP1CB PAK3 PAK3 PRKCA PRKCA CDC42 CDC42 THBS3 THBS3 GRB2 GRB2 BIRC3 BIRC3 FLNA FLNA SPP1 SPP1 PAK2 PAK2 DIAPH1 DIAPH1 CCND1 CCND1 PIP5K1B PIP5K1B PDGFB PDGFB GSK3B GSK3B PAK5 PAK5 LAMA3 LAMA3 FLNC FLNC SHC4 SHC4 SOS2 SOS2 THBS4 THBS4 COL4A2 COL4A2 ITGB7 ITGB7 VEGFC VEGFC CHAD CHAD RHOA RHOA SHC1 SHC1 MAPK1 MAPK1 VAV2 VAV2 TNC TNC SOS1 SOS1 PDGFRA PDGFRA RAC2 RAC2 COL4A3 COL4A3 LAMC3 LAMC3 RAF1 RAF1 MYL12A MYL12A MET MET PAK6 PAK6 PAK1 PAK1 MAPK10 MAPK10 ARHGAP5 ARHGAP5 RASGRF1 RASGRF1 LAMB2 LAMB2 PDGFC PDGFC PIP5K1A PIP5K1A SHC3 SHC3 EGF EGF ITGA5 ITGA5 ITGB3 ITGB3 EGFR EGFR KDR KDR CRKL CRKL MYLK4 MYLK4 PPP1R12A PPP1R12A COL9A1 COL9A1 ITGA1 ITGA1 CAV2 CAV2 ROCK1 ROCK1 ELK1 ELK1 TNR TNR FLT1 FLT1 ITGA8 ITGA8 PIK3CB PIK3CB RAP1B RAP1B PGF PGF PDGFRB PDGFRB CCND2 CCND2 AKT3 AKT3 COL1A2 COL1A2 VAV3 VAV3 PARVG PARVG COL4A5 COL4A5 ITGB1 ITGB1 ITGA2 ITGA2 PIK3R1 PIK3R1 CTNNB1 CTNNB1 ARHGAP35 ARHGAP35 ITGA11 ITGA11 VAV1 VAV1 JUN JUN CCND3 CCND3 PPP1CA PPP1CA BAD BAD PARVA PARVA HGF HGF COMP COMP COL4A1 COL4A1 ILK ILK COL4A6 COL4A6 VEGFA VEGFA CAV1 CAV1 BCAR1 BCAR1 CRK CRK PDPK1 PDPK1 G3TZ74_LOXAF G3TZ74_LOXAF COL6A5 COL6A5 XIAP XIAP PRKCG PRKCG ITGA9 ITGA9 CAV3 CAV3 PIK3R3 PIK3R3 COL2A1 COL2A1 FLNB FLNB TLN2 TLN2 ROCK2 ROCK2 LAMA5 LAMA5 PXN PXN LAMC1 LAMC1 THBS2 THBS2 PIP5K1C PIP5K1C COL9A3 COL9A3 MAPK8 MAPK8 PTK2 PTK2 VEGFB VEGFB SRC SRC IGF1R IGF1R COL1A1 COL1A1 LAMA1 LAMA1 MAPK9 MAPK9 ITGA7 ITGA7 CAPN2 CAPN2 LAMC2 LAMC2 ACTG1 ACTG1 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MYL9Myosin light chain 9. (172 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
ACTN1Actinin alpha 1. (892 aa)
PIK3R2Uncharacterized protein. (724 aa)
LAMB1Laminin subunit beta 1. (1835 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ACTBActin beta. (381 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1038 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (777 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
MYLK2Myosin light chain kinase 2. (605 aa)
VWFVon Willebrand factor. (2812 aa)
TLN1Talin 1. (2547 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1069 aa)
THBS1Thrombospondin 1. (1169 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BIRC2Baculoviral IAP repeat containing 2. (606 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMA2Laminin subunit alpha 2. (3121 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1863 aa)
RELNReelin. (3396 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
COL4A4Collagen type IV alpha 4 chain. (1446 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1036 aa)
MYL12BMyosin light chain 12B. (172 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1045 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1092 aa)
LAMB3Laminin subunit beta 3. (1170 aa)
PAK4P21 (RAC1) activated kinase 4. (579 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
CDC42Uncharacterized protein. (147 aa)
THBS3Thrombospondin 3. (956 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
FLNAFilamin A. (2521 aa)
SPP1Secreted phosphoprotein 1. (310 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
DIAPH1Diaphanous related formin 1. (1272 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PAK5Non-specific serine/threonine protein kinase. (721 aa)
LAMA3Laminin subunit alpha 3. (3198 aa)
FLNCFilamin C. (2736 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
THBS4Thrombospondin 4. (964 aa)
COL4A2Collagen type IV alpha 2 chain. (1661 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (791 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
CHADChondroadherin. (359 aa)
RHOARas homolog family member A. (193 aa)
SHC1SHC adaptor protein 1. (583 aa)
MAPK1Mitogen-activated protein kinase. (329 aa)
VAV2Vav guanine nucleotide exchange factor 2. (866 aa)
TNCTenascin C. (2110 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1316 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
RAC2Rac family small GTPase 2. (194 aa)
COL4A3Collagen type IV alpha 3 chain. (1672 aa)
LAMC3Laminin subunit gamma 3. (1465 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
MYL12AMyosin light chain 12A. (172 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
PAK6Non-specific serine/threonine protein kinase. (683 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
MAPK10Mitogen-activated protein kinase. (466 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1258 aa)
LAMB2Laminin subunit beta 2. (1799 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (528 aa)
SHC3SHC adaptor protein 3. (463 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1168 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1052 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CRKLCRK like proto-oncogene, adaptor protein. (200 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (298 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
COL9A1Collagen type IX alpha 1 chain. (924 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1161 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ELK1ETS transcription factor ELK1. (431 aa)
TNRTenascin R. (1358 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAP1BUncharacterized protein. (184 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (160 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
PARVGParvin gamma. (331 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CTNNB1Catenin beta 1. (780 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (329 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (291 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
BADBCL2 associated agonist of cell death. (206 aa)
PARVAParvin alpha. (272 aa)
HGFUncharacterized protein; Belongs to the peptidase S1 family. (480 aa)
COMPCartilage oligomeric matrix protein. (638 aa)
COL4A1Collagen type IV alpha 1 chain. (1626 aa)
ILKIntegrin linked kinase. (452 aa)
COL4A6Collagen type IV alpha 6 chain. (1651 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (215 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (185 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (869 aa)
CRKCRK proto-oncogene, adaptor protein. (307 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
G3TZ74_LOXAFUncharacterized protein. (2312 aa)
COL6A5Collagen type VI alpha 5 chain. (2259 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
ITGA9Integrin_alpha2 domain-containing protein. (347 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
PIK3R3Uncharacterized protein. (509 aa)
COL2A1Collagen type II alpha 1 chain. (1490 aa)
FLNBFilamin B. (2648 aa)
TLN2Talin 2. (2547 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
LAMA5Laminin IV type A domain-containing protein. (145 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (587 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
THBS2Thrombospondin 2. (1173 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (623 aa)
COL9A3Uncharacterized protein. (682 aa)
MAPK8Mitogen-activated protein kinase. (428 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
SRCTyrosine-protein kinase. (542 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
COL1A1Collagen type I alpha 1 chain. (1455 aa)
LAMA1Laminin subunit alpha 1. (3060 aa)
MAPK9Mitogen-activated protein kinase. (431 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1180 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (623 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
ACTG1Actin gamma 1. (379 aa)
MAPK3Mitogen-activated protein kinase. (327 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (16%) [HD]