(17 nodes) Melanocyte differentiation network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20. (1915 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (735 aa)
	HPS6	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (803 aa)
	TYRP1	Tyrosinase related protein 1. (543 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1043 aa)
	SOX10	SRY-box transcription factor 10. (546 aa)
	SLC24A5	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	LOC111767897	Sodium/potassium/calcium exchanger 5. (501 aa)
	OCA2	OCA2 melanosomal transmembrane protein. (838 aa)
	ENSECAP00000032857	Uncharacterized protein. (46 aa)
	EDNRB	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (447 aa)
	LOC100060806	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
	GLI3	GLI family zinc finger 3. (1581 aa)
	LRMDA	Leucine rich melanocyte differentiation associated. (226 aa)
	MITF	Melanocyte inducing transcription factor. (641 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDNRB	KIT	ENSECAP00000037052	ENSECAP00000011188	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.850
EDNRB	MITF	ENSECAP00000037052	ENSECAP00000051097	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	Melanocyte inducing transcription factor.	0.778
EDNRB	OCA2	ENSECAP00000037052	ENSECAP00000032264	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	OCA2 melanosomal transmembrane protein.	0.486
EDNRB	SLC24A5	ENSECAP00000037052	ENSECAP00000023675	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.501
EDNRB	SOX10	ENSECAP00000037052	ENSECAP00000021648	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	SRY-box transcription factor 10.	0.782
EDNRB	TYRP1	ENSECAP00000037052	ENSECAP00000007884	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	Tyrosinase related protein 1.	0.604
ENSECAP00000032857	HPS6	ENSECAP00000032857	ENSECAP00000003116	Uncharacterized protein.	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.503
HPS1	HPS6	ENSECAP00000002472	ENSECAP00000003116	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.709
HPS1	LOC100060806	ENSECAP00000002472	ENSECAP00000038836	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.615
HPS6	ENSECAP00000032857	ENSECAP00000003116	ENSECAP00000032857	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Uncharacterized protein.	0.503
HPS6	HPS1	ENSECAP00000003116	ENSECAP00000002472	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.	0.709
HPS6	LOC100060806	ENSECAP00000003116	ENSECAP00000038836	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.761
HPS6	SLC24A5	ENSECAP00000003116	ENSECAP00000023675	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.485
HPS6	TYRP1	ENSECAP00000003116	ENSECAP00000007884	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Tyrosinase related protein 1.	0.527
KIT	EDNRB	ENSECAP00000011188	ENSECAP00000037052	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	0.850
KIT	MITF	ENSECAP00000011188	ENSECAP00000051097	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Melanocyte inducing transcription factor.	0.865
KIT	OCA2	ENSECAP00000011188	ENSECAP00000032264	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	OCA2 melanosomal transmembrane protein.	0.527
KIT	SLC24A5	ENSECAP00000011188	ENSECAP00000023675	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.592
KIT	SOX10	ENSECAP00000011188	ENSECAP00000021648	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	SRY-box transcription factor 10.	0.444
KIT	TYRP1	ENSECAP00000011188	ENSECAP00000007884	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosinase related protein 1.	0.698