(37 nodes) Intracellular steroid hormone receptor signaling pathway network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	NKX3-1	NK3 homeobox 1. (240 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
	YAP1	Yes associated protein 1. (508 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	AR	Androgen receptor. (882 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	LOC100629936	Uncharacterized protein. (93 aa)
	SRC	Tyrosine-protein kinase. (551 aa)
	LOC100629895	Uncharacterized protein. (133 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	CST11	Cystatin 11. (138 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (988 aa)
	PHB2	Prohibitin. (299 aa)
	ARID1A	AT-rich interaction domain 1A. (2211 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1239 aa)
	POU4F2	POU domain protein. (406 aa)
	DAXX	Death domain associated protein. (748 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1204 aa)
	PADI2	Peptidyl arginine deiminase 2. (665 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
	CALCOCO1	Calcium binding and coiled-coil domain 1. (691 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (581 aa)
	ESR2	Estrogen receptor 2. (550 aa)
	PHB	Prohibitin. (297 aa)
	TMF1	TATA element modulatory factor 1. (1088 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
	ENSECAP00000031316	Uncharacterized protein. (93 aa)
	KDM3A	Lysine demethylase 3A. (1362 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1324 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (776 aa)
	ENSECAP00000039988	Prohibitin. (299 aa)
	LOC100629841	Uncharacterized protein. (101 aa)
	RBFOX2	RNA binding fox-1 homolog 2. (476 aa)
	ENSECAP00000050152	Uncharacterized protein. (91 aa)
	SAFB	Scaffold attachment factor B. (977 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ARID1A	ENSECAP00000008070	ENSECAP00000016142	Androgen receptor.	AT-rich interaction domain 1A.	0.490
AR	DAXX	ENSECAP00000008070	ENSECAP00000018654	Androgen receptor.	Death domain associated protein.	0.418
AR	DDX5	ENSECAP00000008070	ENSECAP00000009394	Androgen receptor.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.538
AR	ESR1	ENSECAP00000008070	ENSECAP00000020141	Androgen receptor.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.663
AR	ESR2	ENSECAP00000008070	ENSECAP00000022532	Androgen receptor.	Estrogen receptor 2.	0.454
AR	MED1	ENSECAP00000008070	ENSECAP00000007560	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.622
AR	NKX3-1	ENSECAP00000008070	ENSECAP00000001024	Androgen receptor.	NK3 homeobox 1.	0.685
AR	NR3C1	ENSECAP00000008070	ENSECAP00000033878	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.518
AR	NR3C2	ENSECAP00000008070	ENSECAP00000014151	Androgen receptor.	Nuclear receptor subfamily 3 group C member 2.	0.647
AR	SRC	ENSECAP00000008070	ENSECAP00000010024	Androgen receptor.	Tyrosine-protein kinase.	0.675
ARID1A	AR	ENSECAP00000016142	ENSECAP00000008070	AT-rich interaction domain 1A.	Androgen receptor.	0.490
ARID1A	KDM3A	ENSECAP00000016142	ENSECAP00000031388	AT-rich interaction domain 1A.	Lysine demethylase 3A.	0.682
DAXX	AR	ENSECAP00000018654	ENSECAP00000008070	Death domain associated protein.	Androgen receptor.	0.418
DAXX	NR3C1	ENSECAP00000018654	ENSECAP00000033878	Death domain associated protein.	Nuclear receptor subfamily 3 group C member 1.	0.504
DDX17	DDX5	ENSECAP00000029826	ENSECAP00000009394	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.805
DDX17	ESR1	ENSECAP00000029826	ENSECAP00000020141	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.729
DDX17	ESR2	ENSECAP00000029826	ENSECAP00000022532	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.561
DDX5	AR	ENSECAP00000009394	ENSECAP00000008070	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Androgen receptor.	0.538
DDX5	DDX17	ENSECAP00000009394	ENSECAP00000029826	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.805
DDX5	ESR1	ENSECAP00000009394	ENSECAP00000020141	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.814