STRINGSTRING
PIK3C2A PIK3C2A RNASE4 RNASE4 PIGB PIGB PYURF PYURF SOCS3 SOCS3 TMEM246 TMEM246 ABHD4 ABHD4 PIGW PIGW SOCS4 SOCS4 DGAT2L6 DGAT2L6 LOC100070352 LOC100070352 ITPKC ITPKC LPIN2 LPIN2 DPM3 DPM3 ETNK1 ETNK1 FAM102A FAM102A PIGT PIGT PIK3CD PIK3CD AWAT1 AWAT1 PI4K2B PI4K2B PIGG PIGG FABP5 FABP5 ABHD8 ABHD8 PGAP3 PGAP3 PCYT1B PCYT1B LPCAT2 LPCAT2 PIGQ PIGQ AJUBA AJUBA APOA2 APOA2 INPP4B INPP4B AGPAT2 AGPAT2 PIK3C3 PIK3C3 DPM1 DPM1 CHKA CHKA PIGS PIGS CDIPT CDIPT PNPLA2 PNPLA2 CDS1 CDS1 PIGF PIGF DGKA DGKA PTPMT1 PTPMT1 GPAA1 GPAA1 TAMM41 TAMM41 SMG1 SMG1 SLA2 SLA2 PCK1 PCK1 PIGH PIGH PIGK PIGK FGF2 FGF2 PLD2 PLD2 PIK3CA PIK3CA DGAT1 DGAT1 MBOAT7 MBOAT7 PLSCR3 PLSCR3 AWAT2 AWAT2 FIG4 FIG4 PIGZ PIGZ PTDSS1 PTDSS1 PIGO PIGO IP6K1 IP6K1 PIGV PIGV PCYT1A PCYT1A CLN3 CLN3 MOGAT3 MOGAT3 BECN1 BECN1 ITPKA ITPKA CHPT1 CHPT1 PIGP PIGP PIK3CG PIK3CG PIK3R1 PIK3R1 PEMT PEMT SOCS7 SOCS7 F6Y0A2_HORSE F6Y0A2_HORSE LPCAT1 LPCAT1 PIKFYVE PIKFYVE PTDSS2 PTDSS2 RGSL1 RGSL1 PIP4K2B PIP4K2B DGKQ DGKQ LCAT LCAT LOC100070364 LOC100070364 PLCE1 PLCE1 IMPA1 IMPA1 PIK3C2G PIK3C2G LPCAT3 LPCAT3 FAM126A FAM126A CRLS1 CRLS1 UVRAG UVRAG GPAT3 GPAT3 PIK3CB PIK3CB INPP1 INPP1 CWH43 CWH43 DGAT2 DGAT2 MOGAT2 MOGAT2 SOCS1 SOCS1 PIK3R2 PIK3R2 ENSECAP00000023457 ENSECAP00000023457 ENSECAP00000024196 ENSECAP00000024196 PCK2 PCK2 FAM102B FAM102B FAR1 FAR1 LPIN1 LPIN1 ATM ATM LOC111771941 LOC111771941 GPAT2 GPAT2 DGKD DGKD CDS2 CDS2 DGKZ DGKZ IP6K2 IP6K2 ETNK2 ETNK2 PISD PISD CEPT1 CEPT1 PIK3R4 PIK3R4 ITPKB ITPKB PLA2G4A PLA2G4A PIP5K1A PIP5K1A PI4KB PI4KB IMPA2 IMPA2 TMEM150A TMEM150A BPNT1 BPNT1 LOC100052122 LOC100052122 ENSECAP00000031624 ENSECAP00000031624 PIGY PIGY PLCG2 PLCG2 PI4KA PI4KA IMPAD1 IMPAD1 SOCS2 SOCS2 GPAM GPAM PIP5KL1 PIP5KL1 LPIN3 LPIN3 PIP5K1B PIP5K1B DGKG DGKG PIGA PIGA PIGC PIGC PGAP2 PGAP2 ENSECAP00000036553 ENSECAP00000036553 DHRS7B DHRS7B AGPAT4 AGPAT4 PIP4K2C PIP4K2C FAM126B FAM126B ATG14 ATG14 MPPE1 MPPE1 PLA2G6 PLA2G6 ENSECAP00000039423 ENSECAP00000039423 UNC50 UNC50 P3R3URF P3R3URF CHKB CHKB ABHD5 ABHD5 DGKE DGKE MOGAT1 MOGAT1 AGPAT3 AGPAT3 GPAT4 GPAT4 SH3YL1 SH3YL1 AGPAT1 AGPAT1 TTC7B TTC7B VAC14 VAC14 PLD1 PLD1 PIP5K1C PIP5K1C PIGX PIGX PGS1 PGS1 PIP4K2A PIP4K2A PIK3C2B PIK3C2B SLC27A1 SLC27A1 PIGU PIGU PIK3R5 PIK3R5 PIGL PIGL CISH CISH ADA2 ADA2 PCYT2 PCYT2 TTC7A TTC7A EFR3B EFR3B PIGN PIGN PI4K2A PI4K2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1689 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (156 aa)
PIGBMannosyltransferase. (554 aa)
PYURFPIGY upstream reading frame. (114 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
TMEM246Transmembrane protein 246. (403 aa)
ABHD4Abhydrolase domain containing 4. (355 aa)
PIGWPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (526 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
DGAT2L6Diacylglycerol O-acyltransferase 2 like 6. (337 aa)
LOC100070352Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (666 aa)
LPIN2Lipin 2. (922 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
ETNK1Ethanolamine kinase 1. (451 aa)
FAM102AFamily with sequence similarity 102 member A. (475 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis class T. (651 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AWAT1Acyl-CoA wax alcohol acyltransferase 1. (328 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (487 aa)
PIGGPhosphatidylinositol glycan anchor biosynthesis class G. (983 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (158 aa)
ABHD8Abhydrolase domain containing 8. (425 aa)
PGAP3Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (320 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
LPCAT2Lysophosphatidylcholine acyltransferase 2. (544 aa)
PIGQPhosphatidylinositol glycan anchor biosynthesis class Q. (581 aa)
AJUBAAjuba LIM protein. (584 aa)
APOA2Apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. (100 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (937 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (461 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
DPM1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (260 aa)
CHKACholine kinase alpha. (629 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (555 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
PNPLA2Patatin like phospholipase domain containing 2. (491 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (487 aa)
PIGFPhosphatidylinositol glycan anchor biosynthesis class F. (219 aa)
DGKADiacylglycerol kinase. (806 aa)
PTPMT1Protein tyrosine phosphatase mitochondrial 1. (356 aa)
GPAA1Glycosylphosphatidylinositol anchor attachment 1. (683 aa)
TAMM41Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (337 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
SLA2Src like adaptor 2. (262 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PIGHPhosphatidylinositol glycan anchor biosynthesis class H. (188 aa)
PIGKGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (395 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PLD2Phospholipase. (933 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DGAT1O-acyltransferase. (490 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (1014 aa)
PIGZMannosyltransferase. (563 aa)
PTDSS1Phosphatidylserine synthase 1. (473 aa)
PIGOPhosphatidylinositol glycan anchor biosynthesis class O. (1083 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
PIGVGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (496 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (381 aa)
CLN3Battenin. (437 aa)
MOGAT3Monoacylglycerol O-acyltransferase 3. (315 aa)
BECN1Beclin 1. (448 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (518 aa)
PIGPPhosphatidylinositol glycan anchor biosynthesis class P. (256 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (322 aa)
SOCS7Suppressor of cytokine signaling 7. (643 aa)
F6Y0A2_HORSEDolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (76 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (764 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2131 aa)
PTDSS2Phosphatidylserine synthase 2. (498 aa)
RGSL1Regulator of G protein signaling like 1. (1112 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (439 aa)
DGKQDiacylglycerol kinase. (931 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
LOC100070364Phosphatidylinositol-4-phosphate 5-kinase like 1. (396 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
IMPA1Inositol monophosphatase 1. (414 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (486 aa)
FAM126AFamily with sequence similarity 126 member A. (521 aa)
CRLS1Cardiolipin synthase 1. (296 aa)
UVRAGUV radiation resistance associated. (699 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (449 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
INPP1Inositol polyphosphate-1-phosphatase. (400 aa)
CWH43Cell wall biogenesis 43 C-terminal homolog. (929 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (361 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (303 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
PIK3R2Uncharacterized protein. (479 aa)
ENSECAP00000023457Uncharacterized protein. (189 aa)
ENSECAP00000024196DAGKa domain-containing protein. (363 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (646 aa)
FAM102BFamily with sequence similarity 102 member B. (594 aa)
FAR1Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
LPIN1Lipin 1. (1012 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3076 aa)
LOC111771941Mannosyltransferase. (198 aa)
GPAT2Glycerol-3-phosphate acyltransferase 2, mitochondrial. (860 aa)
DGKDDiacylglycerol kinase. (1308 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
DGKZDiacylglycerol kinase. (1111 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
ETNK2Ethanolamine kinase 2. (714 aa)
PISDPhosphatidylserine decarboxylase. (417 aa)
CEPT1Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (554 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1468 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa)
PIP5K1APIPK domain-containing protein. (565 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (822 aa)
IMPA2Inositol-1-monophosphatase. (293 aa)
TMEM150ATransmembrane protein 150A. (271 aa)
BPNT13'(2'), 5'-bisphosphate nucleotidase 1. (323 aa)
LOC100052122Uncharacterized protein. (461 aa)
ENSECAP00000031624SH2 domain-containing protein. (436 aa)
PIGYPhosphatidylinositol N-acetylglucosaminyltransferase subunit Y-like protein. (71 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2152 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
SOCS2Suppressor of cytokine signaling 2. (270 aa)
GPAMGlycerol-3-phosphate acyltransferase, mitochondrial. (900 aa)
PIP5KL1PIPK domain-containing protein. (395 aa)
LPIN3Lipin 3. (927 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (548 aa)
DGKGDiacylglycerol kinase. (819 aa)
PIGAPhosphatidylinositol glycan anchor biosynthesis class A. (506 aa)
PIGCPhosphatidylinosito N-acetylglucosaminyltransferase subunit C-like protein. (297 aa)
PGAP2Post-GPI attachment to proteins 2. (254 aa)
ENSECAP00000036553Uncharacterized protein. (46 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (399 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (591 aa)
FAM126BFamily with sequence similarity 126 member B. (530 aa)
ATG14Autophagy related 14. (510 aa)
MPPE1Metallophosphoesterase 1. (429 aa)
PLA2G6Phospholipase A2 group VI. (1134 aa)
ENSECAP00000039423Uncharacterized protein. (111 aa)
UNC50Inositol polyphosphate-4-phosphatase type I A. (1189 aa)
P3R3URFPIK3R3 upstream reading frame. (95 aa)
CHKBCholine kinase beta. (410 aa)
ABHD5Abhydrolase domain containing 5. (378 aa)
DGKEDiacylglycerol kinase. (603 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (345 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
SH3YL1SH3 and SYLF domain containing 1. (365 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (334 aa)
TTC7BTetratricopeptide repeat domain 7B. (915 aa)
VAC14VAC14 component of PIKFYVE complex. (809 aa)
PLD1Phospholipase. (1189 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PIGXPhosphatidylinositol glycan anchor biosynthesis class X. (276 aa)
PGS1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (554 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (587 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1850 aa)
SLC27A1Solute carrier family 27 member 1. (743 aa)
PIGUPhosphatidylinositol glycan anchor biosynthesis class U. (527 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 6. (890 aa)
PIGLPhosphatidylinositol glycan anchor biosynthesis class L. (252 aa)
CISHCytokine inducible SH2 containing protein. (291 aa)
ADA2Haloacid dehalogenase like hydrolase domain containing 5. (633 aa)
PCYT2Phosphate cytidylyltransferase 2, ethanolamine. (407 aa)
TTC7ATetratricopeptide repeat domain 7A. (881 aa)
EFR3BEFR3 homolog B. (836 aa)
PIGNPhosphatidylinositol glycan anchor biosynthesis class N. (933 aa)
PI4K2API3K/PI4K domain-containing protein. (566 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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