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| | MLYCD | Malonyl-CoA decarboxylase. (568 aa) |
| | PLP1 | Proteolipid protein 1. (396 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (631 aa) |
| | ACSM5 | AMP-binding domain-containing protein. (208 aa) |
| | NANP | N-acetylneuraminic acid phosphatase. (247 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (299 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (685 aa) |
| | HTD2 | Hydroxyacyl-thioester dehydratase type 2. (168 aa) |
| | SUGCT | Succinyl-CoA:glutarate-CoA transferase. (269 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (664 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (933 aa) |
| | CTH | Cystathionine gamma-lyase. (409 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2. (224 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (495 aa) |
| | FADS1 | Fatty acid desaturase 1. (360 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (471 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (550 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2396 aa) |
| | RGN | Regucalcin. (299 aa) |
| | CD74 | CD74 molecule. (272 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa) |
| | BCAT2 | Branched chain amino acid transaminase 2. (480 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (696 aa) |
| | ENSECAP00000037646 | AMP-binding domain-containing protein. (227 aa) |
| | PLA2G1B | Phospholipase A2 isoform 2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (151 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (257 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein. (377 aa) |
| | ACSBG1 | Acyl-CoA synthetase bubblegum family member 1. (738 aa) |
| | SYK | Tyrosine-protein kinase. (716 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (556 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (941 aa) |
| | FADS2 | Fatty acid desaturase 2. (457 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (527 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1896 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (411 aa) |
| | ALOX5AP | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family. (187 aa) |
| | LOC100070719 | Uncharacterized protein. (755 aa) |
| | PNPLA8 | Patatin like phospholipase domain containing 8. (779 aa) |
| | MECR | Mitochondrial trans-2-enoyl-CoA reductase. (396 aa) |
| | ASL | Argininosuccinate lyase. (660 aa) |
| | ALDH1A1 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (548 aa) |
| | ARMC7 | Armadillo repeat containing 7. (198 aa) |
| | LIPC | Lipase C, hepatic type. (499 aa) |
| | ACSM4 | Acyl-CoA synthetase medium chain family member 4. (580 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | GGT5 | Gamma-glutamyltransferase 5. (617 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa) |
| | LOC100146156 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (607 aa) |
| | CBR4 | Carbonyl reductase 4. (237 aa) |
| | LOC106780831 | Uncharacterized protein. (577 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S type. (663 aa) |
| | MGST3 | Microsomal glutathione S-transferase 3. (140 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa) |
| | SDSL | Serine dehydratase like. (435 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (743 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) |
| | LOC100057612 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (555 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (786 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (551 aa) |
| | DHRS9 | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (423 aa) |
| | GGT1 | Uncharacterized protein. (568 aa) |
| | OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (464 aa) |
| | PTGES | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). (153 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | LOC100060483 | FAD-binding PCMH-type domain-containing protein. (440 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein. (284 aa) |
| | SLC27A2 | Solute carrier family 27 member 2. (620 aa) |
| | ASNSD1 | Asparagine synthetase domain containing 1. (643 aa) |
| | ACSM5-2 | Acyl-CoA synthetase medium chain family member 5. (405 aa) |
| | FADS3 | Fatty acid desaturase 3. (449 aa) |
| | ABHD1 | Abhydrolase domain containing 1. (378 aa) |
| | MTHFD1L | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (978 aa) |
| | DHFR | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa) |
| | LIPG | Lipase G, endothelial type. (521 aa) |
| | WDR37 | WD repeat domain 37. (496 aa) |
| | LOC100065392 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (358 aa) |
| | PYCR2 | Uncharacterized protein. (350 aa) |
| | CYP27A1 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (537 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (434 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (703 aa) |
| | TMEM196 | Transmembrane protein 196. (185 aa) |
| | LOC100057758 | Uncharacterized protein. (646 aa) |
| | ENSECAP00000027749 | Phospholipase A(2). (83 aa) |
| | ENSECAP00000027827 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (102 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (345 aa) |
| | BAAT | Bile acid-CoA:amino acid N-acyltransferase. (560 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | GLUL | Glutamine synthetase. (373 aa) |
| | PLA2G4A | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1. (353 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase 1. (445 aa) |
| | ZBTB45 | Zinc finger and BTB domain containing 45. (849 aa) |
| | BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (398 aa) |
| | SDS | Serine dehydratase. (359 aa) |
| | QKI | Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). (341 aa) |
| | PAH | Phenylalanine hydroxylase. (489 aa) |
| | FASN | Fatty acid synthase. (3470 aa) |
| | CARNS1 | Carnosine synthase 1. (953 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (502 aa) |
| | PTGDS | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (200 aa) |
| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (422 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | ASAH2 | Neutral ceramidase. (799 aa) |
| | ACSM3 | Acyl-CoA synthetase medium chain family member 3. (586 aa) |
| | LOC100057768 | Beta_elim_lyase domain-containing protein. (391 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | PLA2G5 | Phospholipase A(2). (158 aa) |
| | ASS1 | Argininosuccinate synthase 1. (509 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | MGLL | Monoglyceride lipase. (346 aa) |
| | SRR | Serine racemase. (339 aa) |
| | PRXL2B | Peroxiredoxin like 2B. (369 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (414 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (303 aa) |
| | THNSL1 | Threonine synthase like 1. (752 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | LTA4H | Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (733 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | LOC100055638 | Uncharacterized protein. (513 aa) |
| | HSDL1 | Hydroxysteroid dehydrogenase like 1. (330 aa) |
| | PTGS1 | Prostaglandin-endoperoxide synthase 1. (599 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (758 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein. (289 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (368 aa) |
| | GLS | Glutaminase. (673 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa) |
| | EDN1 | Endothelin 1. (202 aa) |
| | GATD1 | Glutamine amidotransferase like class 1 domain containing 1. (220 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (398 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | DECR2 | 2,4-dienoyl-CoA reductase 2. (291 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (677 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (699 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa) |
| | AASDHPPT | Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (311 aa) |
| | LOC100066553 | Cytochrome b5 heme-binding domain-containing protein. (511 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (711 aa) |
| | LOC100066417 | Cytochrome b5 heme-binding domain-containing protein. (465 aa) |
| | NAGS | N-acetylglutamate synthase. (529 aa) |
| | DAGLB | Diacylglycerol lipase beta. (672 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (160 aa) |
| | F6ZNN2_HORSE | FA_desaturase domain-containing protein. (156 aa) |
| | GAD1 | Glutamate decarboxylase 1. (594 aa) |
| | THNSL2 | Threonine synthase like 2. (484 aa) |
| | GATM | Glycine amidinotransferase. (473 aa) |
| | SEPHS1 | Selenophosphate synthetase 1. (392 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein. (350 aa) |
| | SCD | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa) |
| | UGDH | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (513 aa) |
| | OAT | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | F7C4G0_HORSE | Cytochrome b5 heme-binding domain-containing protein. (444 aa) |
| | LIPI | Lipase I. (459 aa) |
| | ACSF3 | Acyl-CoA synthetase family member 3. (585 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa) |
| | GOT1L1 | Glutamic-oxaloacetic transaminase 1 like 1. (416 aa) |
| | TMED8 | Transmembrane p24 trafficking protein family member 8. (326 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa) |
| | PLA2G10 | Phospholipase A(2). (160 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa) |
| | PTGES2 | Prostaglandin E synthase 2; Belongs to the GST superfamily. (371 aa) |
| | TECRL | Trans-2,3-enoyl-CoA reductase like. (381 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (430 aa) |
| | NOXRED1 | NADP dependent oxidoreductase domain containing 1. (359 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2453 aa) |
| | PARK7 | Parkinsonism associated deglycase. (268 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa) |
| | TBXAS1 | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (534 aa) |
| | UROS | Uroporphyrinogen III synthase. (264 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa) |
| | UPB1 | Beta-ureidopropionase 1. (384 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (315 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (408 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (486 aa) |
| | LIPH | Lipase H. (451 aa) |
| | MCAT | Malonyl-CoA-acyl carrier protein transacylase. (379 aa) |
| | TECR | Trans-2,3-enoyl-CoA reductase. (346 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (275 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa) |
| | SLC1A3 | Solute carrier family 1 member 3. (542 aa) |
| | HNF1A | HNF1 homeobox A. (631 aa) |
| | LOC100059533 | Uncharacterized protein. (210 aa) |
| | OLAH | Oleoyl-ACP hydrolase. (249 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa) |
| | GSTP1 | Glutathione S-transferase pi 1. (210 aa) |
| | LTC4S | Leukotriene C4 synthase. (150 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (451 aa) |
| | PSPH | Phosphoserine phosphatase. (224 aa) |
