STRINGSTRING
LHCGR LHCGR KDM5B KDM5B WNT9B WNT9B STRA6 STRA6 ASH1L ASH1L GREB1 GREB1 NIPBL NIPBL ESR1 ESR1 MYOCD MYOCD GATA3 GATA3 SMAD4 SMAD4 GREB1L GREB1L HOXA11 HOXA11 FSHR FSHR SRC SRC HOXA9 HOXA9 LHX1 LHX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (741 aa)
KDM5BLysine demethylase 5B. (1536 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
STRA6Stimulated by retinoic acid 6. (711 aa)
ASH1LASH1 like histone lysine methyltransferase. (2963 aa)
GREB1Growth regulating estrogen receptor binding 1. (1951 aa)
NIPBLNipped-B protein. (2805 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
MYOCDMyocardin. (987 aa)
GATA3GATA binding protein 3. (445 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
HOXA11Homeobox A11. (316 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
SRCTyrosine-protein kinase. (551 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
LHX1LIM homeobox 1. (405 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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