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CREB3 CREB3 NPR1 NPR1 AGTR1 AGTR1 MC2R MC2R PRKCE PRKCE LOC100050675 LOC100050675 CALML3 CALML3 ATP2B4 ATP2B4 ATF4 ATF4 CREB3L2 CREB3L2 ATP1B2 ATP1B2 PRKD3 PRKD3 CALM1 CALM1 ATP2B1 ATP2B1 CACNA1I CACNA1I ADCY5 ADCY5 PLCB3 PLCB3 ORAI1 ORAI1 DAGLB DAGLB ADCY4 ADCY4 ATP1B4 ATP1B4 NPPA NPPA CAMK1G CAMK1G LIPE LIPE AGT AGT POMC POMC CYP21A2 CYP21A2 CAMK4 CAMK4 ADCY2 ADCY2 CACNA1F CACNA1F CREB3L4 CREB3L4 CACNA1D CACNA1D CYP11A1 CYP11A1 ATP1B1 ATP1B1 GNAQ GNAQ PDE2A PDE2A PRKCG PRKCG ATP1B3 ATP1B3 CACNA1S CACNA1S CAMK2A CAMK2A PLCB1 PLCB1 ATF6B ATF6B CALML4 CALML4 CACNA1C CACNA1C CACNA1H CACNA1H CAMK1 CAMK1 KCNK9 KCNK9 ATP2B3 ATP2B3 ADCY9 ADCY9 SCARB1 SCARB1 CAMK2D CAMK2D ATP1A4 ATP1A4 ADCY8 ADCY8 PRKD2 PRKD2 ATP1A1 ATP1A1 KCNJ5 KCNJ5 ADCY1 ADCY1 STAR STAR NR4A1 NR4A1 ITPR2 ITPR2 PRKD1 PRKD1 ADCY6 ADCY6 CAMK1D CAMK1D CREB3L1 CREB3L1 ATP1A2 ATP1A2 NR4A2 NR4A2 ADCY3 ADCY3 HAO2 HAO2 ATF2 ATF2 KCNK3 KCNK3 PLCB4 PLCB4 PRKACA PRKACA CALML5 CALML5 GNA11 GNA11 ATP2B2 ATP2B2 PRKCA PRKCA ATP1A3 ATP1A3 ADCY7 ADCY7 DAGLA DAGLA ITPR3 ITPR3 PRKACB PRKACB PRKCB PRKCB CAMK2B CAMK2B CAMK2G CAMK2G CREB3L3 CREB3L3 CREB5 CREB5 PLCB2 PLCB2 CACNA1G CACNA1G LDLR LDLR ITPR1 ITPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3cAMP responsive element binding protein 3. (390 aa)
NPR1Guanylate cyclase. (1058 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
MC2RMelanocortin 2 receptor. (297 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC100050675Uncharacterized protein. (250 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
ATF4Activating transcription factor 4. (334 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2157 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (313 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (354 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
LIPELipase E, hormone sensitive type. (813 aa)
AGTAngiotensinogen; Belongs to the serpin family. (483 aa)
POMCMelanotropin beta; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes; Belongs to the POMC family. (332 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (495 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
GNAQG protein subunit alpha q. (441 aa)
PDE2APhosphodiesterase. (941 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1765 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (563 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
CALML4Calmodulin like 4. (197 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2359 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (412 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (543 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1036 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1021 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (350 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (852 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (395 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1045 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
HAO23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (546 aa)
ATF2Activating transcription factor 2. (512 aa)
KCNK3Potassium channel subfamily K member. (403 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
CALML5Calmodulin like 5. (149 aa)
GNA11G protein subunit alpha 11. (528 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
DAGLADiacylglycerol lipase alpha. (1040 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (656 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2378 aa)
LDLRLow density lipoprotein receptor. (937 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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