(5 nodes) Carboxylesterase type B, active site, and Guanylate kinase activity network (Sus scrofa)

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Your Input:
	CES1-2	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (530 aa)
	ADAL	Adenosine deaminase-like protein isoform X1. (355 aa)
	HINT1	Histidine triad nucleotide binding protein 1. (126 aa)
	GUK1	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. (242 aa)
	CES1	Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] (564 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAL	GUK1	ENSSSCP00000005076	ENSSSCP00000035398	Adenosine deaminase-like protein isoform X1.	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	0.650
ADAL	HINT1	ENSSSCP00000005076	ENSSSCP00000015173	Adenosine deaminase-like protein isoform X1.	Histidine triad nucleotide binding protein 1.	0.514
CES1	CES1-2	ENSSSCP00000040296	ENSSSCP00000003044	Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...]	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.803
CES1-2	CES1	ENSSSCP00000003044	ENSSSCP00000040296	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...]	0.803
CES1-2	GUK1	ENSSSCP00000003044	ENSSSCP00000035398	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	0.494
CES1-2	HINT1	ENSSSCP00000003044	ENSSSCP00000015173	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Histidine triad nucleotide binding protein 1.	0.584
GUK1	ADAL	ENSSSCP00000035398	ENSSSCP00000005076	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	Adenosine deaminase-like protein isoform X1.	0.650
GUK1	CES1-2	ENSSSCP00000035398	ENSSSCP00000003044	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.494
GUK1	HINT1	ENSSSCP00000035398	ENSSSCP00000015173	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	Histidine triad nucleotide binding protein 1.	0.691
HINT1	ADAL	ENSSSCP00000015173	ENSSSCP00000005076	Histidine triad nucleotide binding protein 1.	Adenosine deaminase-like protein isoform X1.	0.514
HINT1	CES1-2	ENSSSCP00000015173	ENSSSCP00000003044	Histidine triad nucleotide binding protein 1.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.584
HINT1	GUK1	ENSSSCP00000015173	ENSSSCP00000035398	Histidine triad nucleotide binding protein 1.	Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors.	0.691