STRINGSTRING
TFEB TFEB LGMN LGMN CLN6 CLN6 CTSS CTSS LOC100515765 LOC100515765 MFSD8 MFSD8 LAMP1 LAMP1 CTSL CTSL TFE3 TFE3 CTSF CTSF CST6 CST6 CTSC CTSC TPP1 TPP1 CSTB CSTB CTSB CTSB BNIP5 BNIP5 CTSD CTSD MCOLN1 MCOLN1 NINJ1 NINJ1 LOC100523964 LOC100523964 CLN3 CLN3 MITF MITF LAMP2 LAMP2 CST3 CST3 CLN8 CLN8 CLN5 CLN5 EEA1 EEA1 NPC2 NPC2 NPC1 NPC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFEBTranscription factor EB. (451 aa)
LGMNLegumain. (438 aa)
CLN6CLN6 transmembrane ER protein. (312 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
LOC100515765Cystatin domain-containing protein. (128 aa)
MFSD8Major facilitator superfamily domain containing 8. (517 aa)
LAMP1Uncharacterized protein. (413 aa)
CTSLCathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (474 aa)
CST6Cystatin E/M; Belongs to the cystatin family. (149 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
TPP1Tripeptidyl-peptidase 1 preproprotein. (572 aa)
CSTBCystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
BNIP5BCL2 interacting protein 5. (651 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa)
MCOLN1Mucolipin 1. (663 aa)
NINJ1Ninjurin 1. (232 aa)
LOC100523964Uncharacterized protein. (349 aa)
CLN3Battenin. (414 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa)
CST3Cystatin C; Belongs to the cystatin family. (146 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (416 aa)
CLN5Ceroid-lipofuscinosis neuronal protein 5. (356 aa)
EEA1Early endosome antigen 1. (1276 aa)
NPC2NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmos [...] (154 aa)
NPC1NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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