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| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa) |
| | CRADD | CASP2 and RIPK1 domain containing adaptor with death domain. (237 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa) |
| | FGR | Tyrosine-protein kinase. (537 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | TEK | TEK receptor tyrosine kinase. (1147 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1093 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (795 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1315 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa) |
| | ANGPT4 | Angiopoietin 4. (503 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1379 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | LOC100515824 | Insulin receptor substrate 1-like isoform X2. (512 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | TXK | Tyrosine-protein kinase. (551 aa) |
| | AREG | Amphiregulin long form. (247 aa) |
| | KL | Klotho. (1011 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | VEGFD | Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | SH3KBP1 | SH3 domain containing kinase binding protein 1. (724 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa) |
| | VEGFB | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa) |
| | PDGFD | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (387 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (532 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | NGFR | Nerve growth factor receptor. (414 aa) |
| | KLB | Klotho beta. (1044 aa) |
| | LAT2 | Linker for activation of T cells family member 2. (253 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | LOC100620540 | Uncharacterized protein. (597 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | LPXN | Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa) |
| | IRS4 | Insulin receptor substrate 4. (1175 aa) |
| | SHC1 | SHC adaptor protein 1. (583 aa) |
| | FYB1 | FYN binding protein 1. (837 aa) |
| | GAB1 | GRB2 associated binding protein 1. (723 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (820 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (820 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (903 aa) |
| | GRB10 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa) |
| | NRG3 | Neuregulin 3. (718 aa) |
| | A0A286ZJU7_PIG | Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (235 aa) |
| | ITK | Tyrosine-protein kinase. (598 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | CBL | Cbl proto-oncogene. (914 aa) |
| | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG. (878 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (385 aa) |
| | BTC | EGF-like domain-containing protein. (342 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa) |
| | SORT1 | Sortilin. (963 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | GRAP2 | GRB2-related adapter protein 2 isoform 1. (320 aa) |
| | RHOQ | Rho-related GTP-binding protein RhoQ. (205 aa) |
| | SH3BP2 | SH3 domain binding protein 2. (622 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | CBLC | Cbl proto-oncogene C. (561 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | NRG1 | Neuregulin 1. (712 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FGFRL1 | Fibroblast growth factor receptor like 1. (566 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (855 aa) |
| | SOCS6 | Suppressor of cytokine signaling 6 isoform X1. (535 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | PECAM1 | Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa) |
| | GRAP | Uncharacterized protein. (313 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (260 aa) |
| | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates [...] (1102 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | CBLB | E3 ubiquitin-protein ligase CBL-B isoform X1. (1047 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (887 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (328 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | GAB2 | GRB2 associated binding protein 2. (740 aa) |
| | IRS2 | Insulin receptor substrate 2. (1092 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (550 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | SKAP1 | Src kinase-associated phosphoprotein 1. (367 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa) |
| | SHC3 | SHC adaptor protein 3. (656 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | KITLG | Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (276 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (385 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa) |
| | SHC2 | Uncharacterized protein. (623 aa) |
| | HCK | Tyrosine-protein kinase. (527 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | NTF4 | Neurotrophin 4; Belongs to the NGF-beta family. (210 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (277 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa) |
| | BLNK | B-cell linker protein isoform 1. (463 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | ANGPT1 | Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (874 aa) |
| | ANGPT2 | Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa) |
| | SPRY1 | Sprouty RTK signaling antagonist 1. (319 aa) |
| | EREG | Epiregulin. (168 aa) |
| | NRG2 | Neuregulin 2. (858 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | NRG4 | Neuregulin 4. (139 aa) |
| | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (512 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (879 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4 isoform X1. (441 aa) |
| | NTRK3 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (942 aa) |
