STRINGSTRING
EBF2 EBF2 SIRT1 SIRT1 ABHD5 ABHD5 CIDEC CIDEC PPARG PPARG PNPLA2 PNPLA2 ESRRA ESRRA PLIN4 PLIN4 UCP2 UCP2 PRDM16 PRDM16 TMEM26 TMEM26 FOXO1 FOXO1 G0S2 G0S2 PPARGC1A PPARGC1A DNAJB5 DNAJB5 NRF1 NRF1 HILPDA HILPDA UCP3 UCP3 FITM2 FITM2 ESRRG ESRRG ZNF516 ZNF516 PLIN5 PLIN5 ISOC1 ISOC1 PLIN1 PLIN1 PDK4 PDK4 PLIN2 PLIN2 CIDEA CIDEA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EBF2EBF transcription factor 2. (575 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl- lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of [...] (336 aa)
CIDECCell death inducing DFFA like effector c. (251 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa)
ESRRASteroid hormone receptor ERR1 isoform X1. (506 aa)
PLIN4Perilipin 4. (1655 aa)
UCP2Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). (308 aa)
PRDM16PR/SET domain 16. (1278 aa)
TMEM26Transmembrane protein 26. (368 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
G0S2G0/G1 switch 2 protein. (103 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
DNAJB5DnaJ heat shock protein family (Hsp40) member B5. (461 aa)
NRF1Nuclear respiratory factor 1 isoform 1. (503 aa)
HILPDAUncharacterized protein. (71 aa)
UCP3Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
FITM2Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Belongs to the FIT family. (283 aa)
ESRRGEstrogen-related receptor gamma isoform 1. (458 aa)
ZNF516Zinc finger protein 516. (1138 aa)
PLIN5Perilipin 5. (736 aa)
ISOC1Isochorismatase domain containing 1. (331 aa)
PLIN1Uncharacterized protein. (578 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PLIN2Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family. (459 aa)
CIDEACIDE-N domain-containing protein. (376 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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