(31 nodes) Motor neuron axon guidance network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PLXNA4	Plexin-A4 isoform X1. (1893 aa)
	RAC2	Rac family small GTPase 2. (217 aa)
	NTN1	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa)
	A0A5G2QL47_PIG	Uncharacterized protein. (116 aa)
	RNF165	Ring finger protein 165. (365 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	RHOG	Uncharacterized protein. (394 aa)
	RAC3	Rac family small GTPase 3. (192 aa)
	CHN1	Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
	A0A287AKX8_PIG	Phorbol-ester/DAG-type domain-containing protein. (114 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	LHX3	LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). (538 aa)
	LHX1	LIM homeobox 1. (436 aa)
	ALCAM	Activated leukocyte cell adhesion molecule. (619 aa)
	PLXNA3	Plexin A3. (1871 aa)
	KIF5C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (956 aa)
	F1RSX1_PIG	Uncharacterized protein. (200 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (800 aa)
	CDK5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	HOXA2	Homeobox protein Hox-A2. (380 aa)
	EPHA4	EPH receptor A4. (986 aa)
	LAMC2	Laminin subunit gamma-2 isoform a. (1191 aa)
	LHX4	LIM homeobox 4. (390 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (777 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	EGR2	E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
	MYCBP2	MYC binding protein 2. (4640 aa)
	SLIT2	Slit guidance ligand 2. (1542 aa)
	NTN3	Netrin 3. (579 aa)
	NTN5	Netrin-5. (499 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287AKX8_PIG	EPHA4	ENSSSCP00000044682	ENSSSCP00000017193	Phorbol-ester/DAG-type domain-containing protein.	EPH receptor A4.	0.422
CDK5	PLXNA3	ENSSSCP00000019921	ENSSSCP00000027839	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Plexin A3.	0.563
CDK5	PLXNA4	ENSSSCP00000019921	ENSSSCP00000031443	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Plexin-A4 isoform X1.	0.562
CDK5	SEMA3A	ENSSSCP00000019921	ENSSSCP00000026074	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Semaphorin 3A; Belongs to the semaphorin family.	0.688
CHN1	EPHA4	ENSSSCP00000045937	ENSSSCP00000017193	Chimaerin; GTPase-activating protein for p21-rac.	EPH receptor A4.	0.422
EPHA4	A0A287AKX8_PIG	ENSSSCP00000017193	ENSSSCP00000044682	EPH receptor A4.	Phorbol-ester/DAG-type domain-containing protein.	0.422
EPHA4	CHN1	ENSSSCP00000017193	ENSSSCP00000045937	EPH receptor A4.	Chimaerin; GTPase-activating protein for p21-rac.	0.422
EPHA4	SEMA3A	ENSSSCP00000017193	ENSSSCP00000026074	EPH receptor A4.	Semaphorin 3A; Belongs to the semaphorin family.	0.578
F1RSX1_PIG	RHOG	ENSSSCP00000026359	ENSSSCP00000051183	Uncharacterized protein.	Uncharacterized protein.	0.901
NTN1	SEMA3A	ENSSSCP00000066172	ENSSSCP00000026074	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...]	Semaphorin 3A; Belongs to the semaphorin family.	0.759
NTN1	SEMA3F	ENSSSCP00000066172	ENSSSCP00000012151	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...]	Semaphorin 3F; Belongs to the semaphorin family.	0.431
NTN1	SLIT1	ENSSSCP00000066172	ENSSSCP00000011201	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...]	Slit guidance ligand 1.	0.783
NTN1	SLIT2	ENSSSCP00000066172	ENSSSCP00000009325	Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...]	Slit guidance ligand 2.	0.653
NTN5	SLIT1	ENSSSCP00000003408	ENSSSCP00000011201	Netrin-5.	Slit guidance ligand 1.	0.454
PLXNA3	CDK5	ENSSSCP00000027839	ENSSSCP00000019921	Plexin A3.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.563
PLXNA3	PLXNA4	ENSSSCP00000027839	ENSSSCP00000031443	Plexin A3.	Plexin-A4 isoform X1.	0.901
PLXNA3	RAC2	ENSSSCP00000027839	ENSSSCP00000070230	Plexin A3.	Rac family small GTPase 2.	0.924
PLXNA3	RAC3	ENSSSCP00000027839	ENSSSCP00000047362	Plexin A3.	Rac family small GTPase 3.	0.924
PLXNA3	SEMA3A	ENSSSCP00000027839	ENSSSCP00000026074	Plexin A3.	Semaphorin 3A; Belongs to the semaphorin family.	0.969
PLXNA3	SEMA3F	ENSSSCP00000027839	ENSSSCP00000012151	Plexin A3.	Semaphorin 3F; Belongs to the semaphorin family.	0.911