STRINGSTRING
C9orf72 C9orf72 VPS13D VPS13D PINK1 PINK1 SNX30 SNX30 LRSAM1 LRSAM1 GNAI3 GNAI3 SH3GLB1 SH3GLB1 WDR24 WDR24 HTT HTT SPTLC1 SPTLC1 HSPB8 HSPB8 SIRT1 SIRT1 BAG3 BAG3 WAC WAC PIP4K2A PIP4K2A FYCO1 FYCO1 WDR45 WDR45 AMBRA1 AMBRA1 IL4 IL4 STING1 STING1 RAB3GAP1 RAB3GAP1 RUFY4 RUFY4 LARP1 LARP1 CALCOCO2 CALCOCO2 ATG2A ATG2A BNIP3 BNIP3 OPTN OPTN I3LND9_PIG I3LND9_PIG RIPK2 RIPK2 KDR KDR SNX18 SNX18 A0A287A155_PIG A0A287A155_PIG SESN3 SESN3 RALB RALB SNX4 SNX4 PAFAH1B2 PAFAH1B2 SNX7 SNX7 SPTLC2 SPTLC2 TBK1 TBK1 ADRB2 ADRB2 HIF1A HIF1A RAB3GAP2 RAB3GAP2 SMCR8 SMCR8 TSC2 TSC2 NOD2 NOD2 MAPK3 MAPK3 TRIM13 TRIM13 SESN2 SESN2 SESN1 SESN1 SCOC SCOC HMOX1 HMOX1 A0A5G2QRP7_PIG A0A5G2QRP7_PIG WIPI1 WIPI1 PIP4K2C PIP4K2C PIP4K2B PIP4K2B SUPT5H SUPT5H
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C9orf72C9orf72-SMCR8 complex subunit. (489 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4389 aa)
PINK1PTEN induced kinase 1. (588 aa)
SNX30Sorting nexin family member 30. (449 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (737 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
WDR24GATOR complex protein WDR24. (790 aa)
HTTHuntingtin. (3138 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (210 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
BAG3BCL2 associated athanogene 3. (609 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1444 aa)
WDR45WD repeat domain 45. (360 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
STING1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (758 aa)
RUFY4RUN and FYVE domain containing 4. (571 aa)
LARP1La ribonucleoprotein domain family member 1. (1101 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (445 aa)
ATG2AAutophagy related 2A. (1929 aa)
BNIP3BCL2 interacting protein 3. (202 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (589 aa)
I3LND9_PIGUncharacterized protein. (1222 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
SNX18Sorting nexin 18. (807 aa)
A0A287A155_PIGUncharacterized protein. (58 aa)
SESN3Sestrin-3 isoform 1. (492 aa)
RALBRAS like proto-oncogene B. (206 aa)
SNX4Sorting nexin 4. (511 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
SNX7Sorting nexin 7. (482 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
TBK1TANK binding kinase TBK1. (729 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1453 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
TSC2TSC complex subunit 2. (1836 aa)
NOD2Uncharacterized protein. (1013 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13 isoform 2. (407 aa)
SESN2Sestrin 2. (471 aa)
SESN1Sestrin 1. (582 aa)
SCOCShort coiled-coil protein. (158 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa)
A0A5G2QRP7_PIGUncharacterized protein. (104 aa)
WIPI1Uncharacterized protein. (477 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
SUPT5HTranscription elongation factor SPT5. (1085 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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