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| | MMUT | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. (750 aa) |
| | PNPO | Pyridoxamine 5'-phosphate oxidase. (261 aa) |
| | OAT | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (609 aa) |
| | CSAD | Cysteine sulfinic acid decarboxylase. (549 aa) |
| | VDR | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa) |
| | FOLR1 | Folate receptor alpha. (346 aa) |
| | OPN4 | Opsin 4. (488 aa) |
| | ISM1 | Isthmin 1. (595 aa) |
| | GADL1 | Glutamate decarboxylase like 1. (552 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (547 aa) |
| | GNMT | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity). (334 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa) |
| | TPK1 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (281 aa) |
| | SDS | Serine dehydratase. (402 aa) |
| | DDC | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (529 aa) |
| | FOLR2 | Folate receptor beta. (319 aa) |
| | EGLN2 | Uncharacterized protein. (257 aa) |
| | TKT | Transketolase. (598 aa) |
| | RBP1 | Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa) |
| | PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (726 aa) |
| | P3H4 | Prolyl 3-hydroxylase family member 4 (non-enzymatic). (455 aa) |
| | ERICH2 | Uncharacterized protein. (219 aa) |
| | EGLN2-2 | Fe2OG dioxygenase domain-containing protein. (125 aa) |
| | PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa) |
| | RBP2 | Retinol-binding protein 2; Intracellular transport of retinol. (184 aa) |
| | AFM | Afamin. (612 aa) |
| | GCAT | Glycine C-acetyltransferase. (467 aa) |
| | KYAT1 | Aminotran_1_2 domain-containing protein. (461 aa) |
| | NFS1 | Cysteine desulfurase, mitochondrial. (457 aa) |
| | CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | ETNPPL | Ethanolamine-phosphate phospho-lyase isoform 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (499 aa) |
| | ADH4 | Alcohol dehydrogenase 4 isoform 2. (380 aa) |
| | CALB1 | Calbindin 1. (261 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (473 aa) |
| | OGFOD2 | 2-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa) |
| | TCN2 | Transcobalamin-2 isoform 1. (429 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa) |
| | EGLN1 | Uncharacterized protein. (427 aa) |
| | RBP3 | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1284 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | MARC2 | Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] (339 aa) |
| | CUBN | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] (3625 aa) |
| | GAD2 | Glutamate decarboxylase 2; Catalyzes the production of GABA. (584 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (376 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1027 aa) |
| | HDC | Histidine decarboxylase. (662 aa) |
| | LMBRD1 | LMBR1 domain containing 1. (552 aa) |
| | CTH | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] (420 aa) |
| | MOCOS | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (897 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa) |
| | ISM2 | AMOP domain-containing protein. (422 aa) |
| | EGLN3 | Egl-9 family hypoxia inducible factor 3. (239 aa) |
| | STRA6 | Stimulated by retinoic acid 6. (666 aa) |
| | P3H3 | Prolyl 3-hydroxylase 3. (727 aa) |
| | DBH | Dopamine beta-hydroxylase. (610 aa) |
| | CRABP2 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa) |
| | ABCA4 | ATP binding cassette subfamily A member 4. (2320 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (471 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (548 aa) |
| | THNSL1 | Threonine synthase like 1. (768 aa) |
| | P4HTM | Prolyl 4-hydroxylase, transmembrane. (496 aa) |
| | ALAS1 | 5-aminolevulinate synthase. (640 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (760 aa) |
| | P3H2 | Prolyl 3-hydroxylase 2 isoform a. (706 aa) |
| | S100G | Protein S100-G, minor isoform; Belongs to the S-100 family. (108 aa) |
| | ALAS2 | 5-aminolevulinate synthase. (587 aa) |
| | CBLIF | Cobalamin binding intrinsic factor. (425 aa) |
| | ACCS | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (506 aa) |
| | ACCSL | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (570 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa) |
| | PLPBP | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (275 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (402 aa) |
| | OGDH | Oxoglutarate dehydrogenase. (1035 aa) |
| | CDCP2 | CUB domain containing protein 2. (540 aa) |
| | THNSL2 | Threonine synthase like 2. (482 aa) |
| | P3H1 | Prolyl 3-hydroxylase 1 isoform 1. (698 aa) |
| | TKTL1 | Transketolase-like protein 1. (596 aa) |
| | SLC46A1 | Uncharacterized protein. (458 aa) |
| | FASN | Uncharacterized protein. (1430 aa) |
| | TKTL2 | Transketolase like 2. (589 aa) |
| | FTCD | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. (533 aa) |
| | CRABP1 | Cellular retinoic acid-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa) |
| | PIGS | Phosphatidylinositol glycan anchor biosynthesis class S. (622 aa) |
| | P4HA3 | Prolyl 4-hydroxylase subunit alpha-3 isoform 1. (544 aa) |
| | SLC19A1 | Solute carrier family 19 member 1. (519 aa) |
| | OPN5 | Opsin 5; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | PDXK | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. (382 aa) |
| | AADAT | Aminoadipate aminotransferase. (522 aa) |
| | OGFOD3 | P4Hc domain-containing protein. (470 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa) |
| | AGXT2 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa) |
| | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 isoform 1. (534 aa) |
| | ABAT | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (520 aa) |
| | OGDHL | Oxoglutarate dehydrogenase like. (978 aa) |
| | TCN1 | Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach (By similarity). Binds to cobalamin and to cobalamin analogs such as cobinamide; Belongs to the eukaryotic cobalamin transport proteins family. (452 aa) |
| | MMACHC | Uncharacterized protein. (223 aa) |
| | RBP4 | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (238 aa) |
| | PAM | Peptidyl-glycine alpha-amidating monooxygenase isoform X1. (972 aa) |
| | RLBP1 | Retinaldehyde binding protein 1. (384 aa) |
| | CYP2R1 | Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (500 aa) |
| | A0A287ACB9_PIG | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (340 aa) |
| | GAD1 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (728 aa) |
| | OGFOD1 | 2-oxoglutarate and iron dependent oxygenase domain containing 1. (560 aa) |
| | LOC100522040 | Formiminotransferase N-terminal subdomain-containing protein isoform 1. (328 aa) |
| | C8G | Complement C8 gamma chain. (257 aa) |
| | GC | GC vitamin D binding protein. (476 aa) |
| | METTL26 | Methyltransferase like 26. (204 aa) |
| | GOT1L1 | Glutamic-oxaloacetic transaminase 1 like 1. (404 aa) |
| | PAEP | Beta-lactoglobulin-1A/1C; Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule. (268 aa) |
| | PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa) |
| | PANK3 | Pantothenate kinase 3. (370 aa) |
| | HACL1 | 2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (600 aa) |
| | A0A287ALX3_PIG | Uncharacterized protein. (302 aa) |
| | DHTKD1 | Putative 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial. (864 aa) |
| | CRTAP | Cartilage-associated protein. (401 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (561 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa) |
| | LOC110261667 | Uncharacterized protein. (495 aa) |
| | PDXDC1 | Pyridoxal dependent decarboxylase domain containing 1. (864 aa) |
| | PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa) |
| | PYGM | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa) |
| | P4HA2 | Prolyl 4-hydroxylase subunit alpha 2. (555 aa) |
| | MTARC1 | Mitochondrial amidoxime-reducing component 1. (341 aa) |
