(6 nodes) pre-mRNA 3-splice site binding network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	U2AF2	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
	SLU7	Pre-mRNA-splicing factor SLU7 isoform X1. (586 aa)
	U2AF1L4	Splicing factor U2AF 35 kDa subunit-like protein isoform 2. (247 aa)
	LOC396706	C3H1-type domain-containing protein. (263 aa)
	U2AF1	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). (239 aa)
	ZRSR2	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2. (479 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC396706	U2AF1	ENSSSCP00000041877	ENSSSCP00000044103	C3H1-type domain-containing protein.	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	0.600
LOC396706	U2AF1L4	ENSSSCP00000041877	ENSSSCP00000037692	C3H1-type domain-containing protein.	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	0.623
LOC396706	U2AF2	ENSSSCP00000041877	ENSSSCP00000042718	C3H1-type domain-containing protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.901
LOC396706	ZRSR2	ENSSSCP00000041877	ENSSSCP00000068278	C3H1-type domain-containing protein.	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2.	0.545
SLU7	U2AF1	ENSSSCP00000018045	ENSSSCP00000044103	Pre-mRNA-splicing factor SLU7 isoform X1.	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	0.537
SLU7	U2AF1L4	ENSSSCP00000018045	ENSSSCP00000037692	Pre-mRNA-splicing factor SLU7 isoform X1.	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	0.537
SLU7	U2AF2	ENSSSCP00000018045	ENSSSCP00000042718	Pre-mRNA-splicing factor SLU7 isoform X1.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.857
U2AF1	LOC396706	ENSSSCP00000044103	ENSSSCP00000041877	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	C3H1-type domain-containing protein.	0.600
U2AF1	SLU7	ENSSSCP00000044103	ENSSSCP00000018045	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	Pre-mRNA-splicing factor SLU7 isoform X1.	0.537
U2AF1	U2AF1L4	ENSSSCP00000044103	ENSSSCP00000037692	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	0.901
U2AF1	U2AF2	ENSSSCP00000044103	ENSSSCP00000042718	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.994
U2AF1	ZRSR2	ENSSSCP00000044103	ENSSSCP00000068278	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2.	0.615
U2AF1L4	LOC396706	ENSSSCP00000037692	ENSSSCP00000041877	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	C3H1-type domain-containing protein.	0.623
U2AF1L4	SLU7	ENSSSCP00000037692	ENSSSCP00000018045	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	Pre-mRNA-splicing factor SLU7 isoform X1.	0.537
U2AF1L4	U2AF1	ENSSSCP00000037692	ENSSSCP00000044103	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	0.901
U2AF1L4	U2AF2	ENSSSCP00000037692	ENSSSCP00000042718	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.990
U2AF1L4	ZRSR2	ENSSSCP00000037692	ENSSSCP00000068278	Splicing factor U2AF 35 kDa subunit-like protein isoform 2.	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2.	0.600
U2AF2	LOC396706	ENSSSCP00000042718	ENSSSCP00000041877	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	C3H1-type domain-containing protein.	0.901
U2AF2	SLU7	ENSSSCP00000042718	ENSSSCP00000018045	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	Pre-mRNA-splicing factor SLU7 isoform X1.	0.857
U2AF2	U2AF1	ENSSSCP00000042718	ENSSSCP00000044103	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity).	0.994