STRINGSTRING
ERN2 ERN2 ATF6 ATF6 VAPB VAPB CCND1 CCND1 RHBDD2 RHBDD2 ATF4 ATF4 EIF2AK2 EIF2AK2 HERPUD1 HERPUD1 HSPA5 HSPA5 WFS1 WFS1 BHLHA15 BHLHA15 DERL3 DERL3 A0A287B1R4_PIG A0A287B1R4_PIG XBP1 XBP1 YOD1 YOD1 DDIT3 DDIT3 AMFR AMFR OS9 OS9 PTPN1 PTPN1 TMTC4 TMTC4 EIF2S1 EIF2S1 DNAJC10 DNAJC10 TBL2 TBL2 DERL1 DERL1 SERP2 SERP2 DERL2 DERL2 CREB3 CREB3 SERP1 SERP1 ATF6B ATF6B EIF2AK3 EIF2AK3 EP300 EP300 ERN1 ERN1 CREB3L2 CREB3L2 ATF3 ATF3 CREB3L3 CREB3L3 CREB3L4 CREB3L4 PARP16 PARP16 SELENOS SELENOS ERLEC1 ERLEC1 HERPUD2 HERPUD2 CDK5RAP3 CDK5RAP3 CREB3L1 CREB3L1 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERN2Endoplasmic reticulum to nucleus signaling 2. (989 aa)
ATF6Activating transcription factor 6. (680 aa)
VAPBVesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
ATF4Activating transcription factor 4. (329 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (389 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa)
WFS1Wolframin ER transmembrane glycoprotein. (889 aa)
BHLHA15Basic helix-loop-helix family member a15. (234 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
A0A287B1R4_PIGUncharacterized protein. (34 aa)
XBP1BZIP domain-containing protein. (378 aa)
YOD1YOD1 deubiquitinase. (306 aa)
DDIT3DNA-damage-inducible transcript 3. (167 aa)
AMFRAutocrine motility factor receptor. (731 aa)
OS9OS9 endoplasmic reticulum lectin. (665 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (762 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
DNAJC10DnaJ heat shock protein family (Hsp40) member C10. (803 aa)
TBL2Transducin beta like 2. (465 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
SERP2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa)
EP300E1A binding protein p300. (2420 aa)
ERN1Uncharacterized protein. (1029 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PARP16Poly [ADP-ribose] polymerase. (322 aa)
SELENOSSelenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa)
ERLEC1Endoplasmic reticulum lectin 1. (487 aa)
HERPUD2HERPUD family member 2. (435 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (513 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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